NSAIDs
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| What is the mechanism of action of NSAIDs? | inhibits cyclooxygenase (COX) and prostaglandin synthesis pathway that is responsible for mediating information about pain to the brain
🗑
|
||||
| Both the COX1 and COX2 pathways convert arachidonic acid to __________ which are implicated in pain, inflammation, cell proliferation, and other key biologic responses | prostaglandins
🗑
|
||||
| What are 4 problems with COX inhibitors? | multiple side effects, frequent allergic reactions, some drugs require daily dosing for efficacy, ceiling effects
🗑
|
||||
| As a general rule, COX2 inhibitors have fewer complications and reactions, but more specific ________ effects | cardiac
🗑
|
||||
| At therapeutic doses, COX2 inhibitors lack the ________ effects found with other NSAIDs like COX1 | platelet
🗑
|
||||
| The risk of acute MI or CVA increases with prolonged use of which drug class? | COX 2
🗑
|
||||
| Compared with Cox-1 class, Cox-2 drugs have _________ GI effects | decreased
🗑
|
||||
| People with asthma and nasal polyps have a higher incidence of allergic reaction to which drugs? | aspirin and other NSAIDs
🗑
|
||||
| How are NSAIDs metabolized? | well absorbed from GI tract in oral doses, then metabolized by CP450 in the liver, 2% is excreted unchanged renally
🗑
|
||||
| In what patient populations would you use caution in administering NSAIDs? | history of GI bleed, renal injuries/failure, liver disease/failure, bleeding disorders, history of MI (esp. acute)
🗑
|
||||
| What is regulated by normal Cox-1 pathway function? | GI blood flow, renal system, platelet aggregation, and macrophages
🗑
|
||||
| What is regulated by normal Cox-2 pathway function? | bronchodilation and vasodilation
🗑
|
||||
| What are some side effects of NSAID use? | GI toxicity, coagulation issues (cox-1), increased risk for MI (cox 1 & 2), hypertension, renal issues, hepatotoxicity, allergy, triggers bronchoconstriction (cox-2) especially in asthma patients, meningitis, slowed bone healing
🗑
|
||||
| How do ACE inhibitors or Beta Blockers affect NSAIDs? | reduce effectiveness of NSAIDs
🗑
|
||||
| How long should a patient be off of aspirin before surgery? | 1 week; if taken during this time frame, get an aspirin platelet function assay
🗑
|
||||
| Does aspirin cause histamine release? | no
🗑
|
||||
| What are 4 major side effects of aspirin therapy? | GI tract dysfunction, platelet inhibition, hepatic dysfunction, renal dysfunction
🗑
|
||||
| Which NSAID is an excellent anti-inflammatory and analgesic with little to no billiary effects and fewer GI effects? | Ketorolac (Toradol)
🗑
|
||||
| What is the peak onset time for ketorolac? | 45 - 60 minutes IM; 20 - 30 minutes IV
🗑
|
||||
| What are some side effects of ketorolac? | inhibits platelet production and aggregation (however, in anesthesia does not cause with 1 or 2 doses), bronchospasm, renal toxicity (though less so than other NSAIDs)
🗑
|
||||
| In what type of surgery would you want to avoid ketorolac administration? | spinal surgery
🗑
|
||||
| What is the dose of IV acetaminophen for pain relief? | 1 gram IVPB over 15 minutes Q 6
🗑
|
||||
| What is the dose of IV acetaminophen for hyperpyrexia? | 650 mg IVPB over 15 minutes Q 4-6
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
Mary Beth
Popular Pharmacology sets