opioids
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Where do opioid agonists bind to opioid receptors? | presynaptic and postsynaptic sites in the CNS (brain and spinal cord) and peripheral sites (primary afferent neurons).
🗑
|
||||
| Opioids act like ________ _________ that normally activate opioid receptors. | endogenous peptides
🗑
|
||||
| What are 3 examples of endogenous peptides that normally activate opioid receptors? | enkephalins, endorphins, and dynorphins
🗑
|
||||
| What are the 4 phases of nocioception (the pain pathway)? | transduction, transmission, perception, modulation
🗑
|
||||
| Unlike inhalation agents, opioids do not cause changes in _____________ | autregulation
🗑
|
||||
| What are 4 favorable opioid properties? | analgesia, preservation of blood flow auto regulation (CNS, heart, kidneys), minimal cardiac depression with maintenance of hemodynamics, blunting of autonomic responses to sympathetic stimulation (surgical stress, laryngoscopy)
🗑
|
||||
| By getting opioids on board before surgery starts, you can decrease what 2 things? | catecholamine release and endocrine response to surgical stress
🗑
|
||||
| What is the principle effect of opioid receptor agonism? | a decrease in neurotransmission
🗑
|
||||
| What 2 things does activation of the opioid receptor cause? | 1).closure of the voltage-gated Ca++ channels on presynaptic nerve terminals; 2).Opening of K+ channels to hyper polarize cell, causing inhibition of postynaptic neurons
🗑
|
||||
| What does the closure of the voltage-gated Ca++ channels in presynpatic nerve terminals once the opioid receptor is activated cause? | a reduction of the release of neurotransmitters
🗑
|
||||
| What are the 6 neurotransmitters whose release is affected by opioid receptor activation? | glutamate, acetylcholine, dopamine, norepinephrine, serotonin, and substance P
🗑
|
||||
| This type of receptor which opioids bind to constitutes 80% of all known receptors and includes muscarinic, adrenergic, gamma-aminobutyric acid, and somatostatin receptors. | Guanine (G) protein-coupled receptors
🗑
|
||||
| When the opioid receptor is activated and K+ channels are opened the cell is hyper polarized, meaning what? | hyper polarization of the cell means inhibiting the post-synaptic neurons & preventing excitation or propagation of action potentials
🗑
|
||||
| Is Ca++ channel closure presynaptic or postsynaptic? | presynaptic
🗑
|
||||
| Is K+ channel opening and resultant hyper polarization of the cell presynaptic or postsynaptic? | postsynaptic
🗑
|
||||
| What occurs during the transduction phase of the of the pain pathway? | noxious stimuli (chemical, thermal, mechanical) is converted to an electrical impulse in sensory nerve endings
🗑
|
||||
| What occurs during the transmission phase of the pain pathway? | conduction of electrical impulses to the CNS
🗑
|
||||
| What occurs during the modulation of pain phase of the pain pathway? | altering pain transmission - both inhibitory and excitatory mechanism modulates pain impulse transmission in peripheral and CNS
🗑
|
||||
| What occurs during the pain perception phase of the pain pathway? | occurs at the thalamus with the cortex input for discrimination of specific sensory experiences
🗑
|
||||
| What are the Mu1 and Mu2 receptor agonists? | endorphins, morphine and synthetic opioids
🗑
|
||||
| What are the 6 effects of Mu1 receptors? | analgesia (spinal & supraspinal), euphoria, miosis, bardycardia, hypothermia, urinary retention
🗑
|
||||
| What are the 4 effects of Mu2 receptors? Which on of these is the principle effect of this type of receptor? | analgesia (spinal), respiratory depression, physical dependence, constipation; respiratory depression is primary effect of of this receptor
🗑
|
||||
| True or False: cloning supports the existence of Mu1 and Mu2 receptors separately | False! Cloning does NOT support the existence of Mu1 and Mu2 receptors separately. Mu receptors are the universal site of action for all endogenous opioid receptors.
🗑
|
||||
| What are the Kappa receptor agonists? | dynorphins and agonist-antagonists
🗑
|
||||
| What are the 6 effects of kappa receptors? | analgesia (spinal & supraspinal), sedation, dysphoria, miosis, diuresis, respiratory depression
🗑
|
||||
| True or False: the analgesia effect from kappa receptors is stronger than that of Mu receptors | False! analgesia from kappa receptors is NOT as strong as that of mu receptors
🗑
|
||||
| Why do opioid agonist-antagonist drugs not cause respiratory depression? | they antagonize mu 2 receptors (primary effect of Mu2 is respiratory depression)
🗑
|
||||
| What are 2 valid indications for opioid agonist-antagonist drugs? | laboring patients and chronic opioid abusers
🗑
|
||||
| What is the agonist for delta receptors? | enkephalins
🗑
|
||||
| What are the 5 effects of the delta receptors? | analgesia (spinal, supraspinal), respiratory depression, physical dependence, urinary retention, mild constipation
🗑
|
||||
| Which receptor has worse potential for constipation: Mu 2 or Delta? | Mu 2
🗑
|
||||
| Which receptor has worse potential for respiratory depression: Mu2, kappa, or delta? | Mu 2
🗑
|
||||
| Opioids directly inhibit the ascending transmission of nociception information from where? | the spinal cord dorsal horn
🗑
|
||||
| Opioids activate pain control pathways that descend from the midbrain, via the rostral ventromedial medulla to the ________________ | spinal cord dorsal horn
🗑
|
||||
| Which types of receptors are present in high concentrations in the dorsal horn of the spinal cord? | mu, kappa, and delta
🗑
|
||||
| What are 3 supraspinal locations where opioid receptors are found? | rostral ventral medulla, locus ceruleus, midbrain periaqueductal gray area
🗑
|
||||
| Exogenous opioids act on the brain circuits by stimulation the release of what? | endogenous opioid peptides
🗑
|
||||
| True or false: studies have shown that opioids have effects outside the CNS | true
🗑
|
||||
| Do opioids have direct cardiovascular effects on healthy, supine, normovolemic patients? | No. Little direct effect even if very large doses (10x) are given
🗑
|
||||
| Opioids have ______ effect on myocardial contractility | little
🗑
|
||||
| Opioids are a ______ option for patients with CHF/decreased LV function | great
🗑
|
||||
| Opioids ________ sympathetic nervous system tone and response to stimulation | decrease
🗑
|
||||
| What are 4 examples of decreased sympathetic nervous system tone caused by opioids? | venous dilation (pooling), decreased venous return, decreased CO & BP, orthostatic hypotension
🗑
|
||||
| Sufentanil and Alfentanil caused direct relaxation of _____________ | aortic smooth muscle
🗑
|
||||
| What is the reason for a decreases in heart rate seen with opioids? | stimulation of vagal nucleus in the medulla, SA node depression, slowed conduction through the AV node
🗑
|
||||
| Opioid-induced bradycardia is response to what? | atropine or glycopyrrolate
🗑
|
||||
| A synergistic drop in BP occurs when opioids are combined with what? | benzodiazepines or nitrous oxide
🗑
|
||||
| A reduced size of MI was found to occur when one of these two drugs was administered proper to occlusion of coronary artery | morphine and remifentanil
🗑
|
||||
| Which opioid has antimuscarinic effects and may cause tachycardia? | meperidine (demerol)
🗑
|
||||
| Opioids cause a decreased responsiveness to PaCO2 causing the CO2 response curve to shift which way? | to the right
🗑
|
||||
| Through direct effect at mu2 receptors, opioids cause direct depression of what? | brainstem ventilation centers
🗑
|
||||
| Opioids cause a decreased release of Ach from neurons in the medullary respiratory centers which may effect respiratory depression. This can be reversed by which anticholinesterase drug? Why? | physostigmine; because it crosses the blood brain barrier; it may reverse respiratory depression without reversing analgesia
🗑
|
||||
| High doses of opioids may result in _______ without loss of consciousness | apnea
🗑
|
||||
| How do opioids cause a decrease in minute ventilation? | by slowing down the respiratory rate but increasing tidal volumes
🗑
|
||||
| What factors accentuate the ventilatory depression caused by opioids? | older age, occurrence of natural sleep
🗑
|
||||
| What factors attenuate the ventilatory depression caused by opioids? | pain of surgery
🗑
|
||||
| Ventilatory depression causes an increase in what? | PaCO2
🗑
|
||||
| What patient populations would poorly tolerate an increase in PaCO2 secondary to ventilatory depression caused by opioids? | patients with increased ICP, asthma, COPD, or for pulmonale
🗑
|
||||
| Which effect of opioids causes death with overdose? | respiratory depression
🗑
|
||||
| Is cough suppression secondary to opioids attributed to the same effect of opioids that causes respiratory depression? | No; it is a separate effect from ventilatory depression. it is due to the effect on medullary cough centers
🗑
|
||||
| With opioid usage, respiration are tied to amount of __________ | stimulation; important for the CRNA to assess respirations during minimal stimulation
🗑
|
||||
| Opioids cause a dose-dependent depression of ____________ in the airways | ciliary activity
🗑
|
||||
| Increased airway resistance might be result of effect on bronchial smooth muscle and an indirect effect of ________________ | histamine release
🗑
|
||||
| The principal effects of opioids are on what body system? | the CNS
🗑
|
||||
| Opioids are most effective on which type of pain? | visceral continuous dull pain
🗑
|
||||
| Opioids are least effective on which type of pain? | chronic, neuropathic pain
🗑
|
||||
| Opioids provide analgesia to tackle what two components of pain? | they reduce both the sensory and affective (emotional) components of pain
🗑
|
||||
| Are opioids anesthetic? | NO!
🗑
|
||||
| True or false: opioids provide reliable amnesia | False! Opioids DO NOT provide reliable amnesia, though they may cause sedation
🗑
|
||||
| What dosage of opioid can cause amnesia or lack of movement? | There is NO dose of opioid that can cause anesthesia! Unconsciousness & sedation are not the same as anesthesia!
🗑
|
||||
| How do opioids affect MAC of inhalational anesthetics? | opioids reduce MAC of inhalational anesthetics
🗑
|
||||
| Sedation occurs in up to ____ of patients receiving morphine | 60%
🗑
|
||||
| _______ precedes the onset of analgesia | sedation
🗑
|
||||
| True or false: opioids promote deep sleep | False! Opioids disrupt normal REM and non-REM sleep
🗑
|
||||
| As long as hypercarbia is avoided, opioids cause cerebral vaso___________, a _________ in cerebral blood flow, and a(n) _________ in ICP | constriction; decrease; decrease
🗑
|
||||
| Opioids _________ cerebral oxygen consumption | decrease; however, effect is less than that of barbiturates
🗑
|
||||
| List some reasons why opioids should be used with caution in patients with head injuries | sedative effect and miosis makes neuro checks difficult, hypoventilation causes increase in PaCO2 causing cerebral vasodilation and an increase in ICP, increased sensitivity to opioids if blood brain barrier not intact
🗑
|
||||
| Opioids cause miosis related to an excitatory action on the ____________ | autonomic nervous system
🗑
|
||||
| True or false: pupillary constriction is an accurate indication of opioid levels | False! other drugs can cause miosis as well, not reliable indicator
🗑
|
||||
| What is stiff chest syndrome? | an intensification of tone of large muscles of the thorax and abdomen related to opioid administration
🗑
|
||||
| Which specific opioid drugs are associated with the incidence of stiff chest syndrome? | fentanyl, sufentanil, alfentanil
🗑
|
||||
| What can help prevent stiff chest syndrome? | slow administration of opioid, avoidance of nitrous oxide during induction
🗑
|
||||
| What are 2 methods of treating stiff chest syndrome? | Reversal with narcan or muscle relaxation with NMBs
🗑
|
||||
| What patient population and circumstances would you most likely see stiff chest syndrome in? | pediatrics; most common with large doses of opioids
🗑
|
||||
| Other than stiff chest syndrome, what can sufentanil cause that would make ventilating a patient difficult? | closure of vocal cords
🗑
|
||||
| Incidence of difficult ventilation with administration of sufentanil is _______ considering both possible causes | 84 - 100%
🗑
|
||||
| Nausea and vomiting related to opioid use is thought to be caused by direct stimulation of the ________________ on the floor of the fourth ventricle | chemoreceptor trigger zone (CRZ)
🗑
|
||||
| What are 4 reasons (other than the chemoreceptor trigger zone stimulation) as to why opioids can cause nausea and vomiting? | increased gastric secretions, delayed gastric emptying, vestibular component (ambulatory patients affected more), pain
🗑
|
||||
| What is a method to combat nausea and vomiting r/t opioids in ambulatory surgery patients? | load them up with IV fluids to combat orthostatic hypotension which contributes to nausea & vomiting
🗑
|
||||
| What can opioids cause that mimics angina pectoris? | biliary spasm - sphincter of Oddi specifically; increases intrabiliary pressure causing epigastric distress & chest pain
🗑
|
||||
| What medications can relieve the biliary spasm caused by opioids? | nitroglycerin, naloxone (narcan), glucagon
🗑
|
||||
| True or false: the EKG tracing will show changes that mimic cardiac changes when patient experiencing intrabiliary spasm r/t opioid administration | True! However, the EKG changes will go away if pt treated with nitro, narcan, or glucagon
🗑
|
||||
| Due to sphincter of Oddi spasms, opioid administration can interfere with intraoperative cholangiograms. What medication might the surgeon ask the CRNA to administer to ensure blockage not due to biliary spasm? | glucagon
🗑
|
||||
| Why do opioids cause urinary retention? | increase in bladder sphincter tone & increase in detrusor muscle tone causing urgency
🗑
|
||||
| What are some of the implications related to opioids easily crossing the placenta? | though NOT teratogenic, opioids may cause depressed neonate & neonate of addicted mother can go through withdrawal
🗑
|
||||
| True allergies to opioids are rare. Histamine release, urticaria, or local reaction are more common with which 2 opioids and why? | morphine and meperidine; morphine > meperidine in terms of histamine displacement, fentanyl class of drugs does not
🗑
|
||||
| What are 2 ways in which opioids may actually help nausea and vomiting rather than cause it? | decrease pain, which often contributes to N/V; higher or repeat IV dosing can depress vomiting center in the medulla
🗑
|
||||
| What is the rational for pretreating with H1 and H2 blockers before administering morphine? | these drugs do not prevent displacement of histamine caused by morphine but prevent significant changes in BP and SVR r/t histamine
🗑
|
||||
| What is tolerance as it relates to opioid use? | development of increased dose needed to achieve same analgesia as previously experienced with smaller dose; usually requires 2 - 3 weeks to develop
🗑
|
||||
| What opioid effects can a person develop tolerance to? | analgesic, euphoric, sedative, respiratory depression, emetic
🗑
|
||||
| What 2 opioid effects can patients not develop tolerance to? | miosis, constipation
🗑
|
||||
| What are 3 theories that account for the development of opioid tolerance? | opioid receptor desensitization, down-regulation of receptors, up-regulation of cAMP system
🗑
|
||||
| What is physical dependence as it related to opioid use? | development of both psychological, compulsive desire and physical need for opioid; addiction more likely with agonists than agonist-antagonists
🗑
|
||||
| Dependence on morphine requires ______ to develop, but some degree of physical need developed within _______ of continuous use | 25 days; 48 hours
🗑
|
||||
| Discontinuation of opioids in those who are physically dependent produces what 4 symptoms? | yawning, diaphoresis, lacrimation, coryza
🗑
|
||||
| Opioids affect the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-gonadal axis. What are the results of opioid affecting these two systems? | decreased plasma cortisol levels with prolonged therapy; increased prolactin, decreased LH, FSH, testosterone, and estrogen
🗑
|
||||
| Why is demerol (or morphine) a good drug for post op shivering? What are the implications of administering it for this purpose? | decreases shivering secondary to resetting the temperature equilibrium point in the hypothalamus; if you give them opioid for this reason, you must provide warmth to prevent low body temperature
🗑
|
||||
| How does prolonged opioid exposure depress the immune system? | alters the development, differentiation and function of bone marrow progenitor cells, macrophages, and T cells
🗑
|
||||
| True or false: opioid receptors are present on immune cells | True!
🗑
|
||||
| What is the triad of symptoms seen with opioid overdose? | miosis, hypoventilation and coma
🗑
|
||||
| Opioids rapidly leave the blood compartment and move to highly perfused tissues such as.....? | brain, lungs, liver, kidneys, spleen
🗑
|
||||
| Significant amount of opioids can be taken up by the ______ on "first pass uptake" and can be returned to circulation later. | lungs
🗑
|
||||
| The amount of uptake of opioids by the lungs is influenced by what 3 things? | prior accumulation of another drug or inhalation anesthetic administration decreases uptake of opioid by lungs; smokers have increased uptake of opioid by the lungs (this means they are resistant to opioids)
🗑
|
||||
| The effect of small opioid doses is terminated by __________; larger doses depend on __________ | redistribution; metabolism
🗑
|
||||
| Most opioids are chiefly metabolized by the _______ with varying clearance rates and elimination half lives | liver
🗑
|
||||
| Clearance is dependent on what? | hepatic blood flow; so in decreased cardiac output there will be longer effect
🗑
|
||||
| Which opioid is different from the others in terms of metabolism? How? | Remifentanil; metabolized by ester hydrolysis by plasma esterases (NOT affected by plasmacholinesterase deficiency)
🗑
|
||||
| Which 2 opioids have active metabolites? | morphine and meperidine
🗑
|
||||
| What do the active metabolites of morphine cause? | M6G is more potent than morphine and has same effects
🗑
|
||||
| What does the active metabolite of meperidine cause? | normeperidine is a CNS stimulant which could cause seizures (more likely with repeated doses in renal failure patients)
🗑
|
||||
| Which opioid has the lowest lipid solubility and therefore the slowest onset? | morphine; takes 15 - 30 minutes to reach equilibration between brain and blood (peak CNS effect)
🗑
|
||||
| What is the duration of action of morphine? | 4 hours; this is why it is a great drug for post op pain
🗑
|
||||
| Doses of up to __________ are used as IM premedication or IV as portion of general anesthetic | 0.1 - 0.2 mg/kg (ideal dose 0.05 - 0.1 mg/kg)
🗑
|
||||
| Morphine decreases the MAC of volatile anesthetics in a dose-dependent manner with the ceiling effect at _________ | 65% MAC
🗑
|
||||
| Only <0.01% of morphine administered enters the CNS at peak plasma concentrations. What 4 things account for this? | low lipid solubility, high degree of ionization at physiologic pH, protein binding, rapid conjugation with glucoronic acid (metabolism)
🗑
|
||||
| Unlike the fentanyl class of drugs, morphine is not taken up by the _____ in first pass | lungs
🗑
|
||||
| Which patient would you be more concerned about the potential for overdose of morphine with: liver failure or renal failure? | Renal failure - r/t elimination rate of active metabolites
🗑
|
||||
| When liver metabolism is impaired, increased rates of _____________ of morphine may be possible | renal metabolism
🗑
|
||||
| What are 4 differences in how women respond to morphine when compared to men? | greater analgesic potency, slower offset and onset, no effect on apneic threshold, hypoxic sensitivity decreased
🗑
|
||||
| Meperidine was discovered during the search for a synthetic ________ like drug | atropine; meperidine and atropine have a similar chemical structure
🗑
|
||||
| Meperidine causes an increase in __________ and some large airway _________ | heart rate; bronchodilation
🗑
|
||||
| Meperidine can cause myocardial depression at doses above _______ | 2 mg/kg (which is just 2x normal dose)
🗑
|
||||
| What is the reason for the link between meperidine and PONV, especially in pediatrics? | sensitizes the labyrinthine apparatus resulting in dizziness and N/V
🗑
|
||||
| Meperidine is a synthetic opioid agonist at ___ and ____ receptors | mu and kappa
🗑
|
||||
| What is the potency of Meperidine (demerol) when compared to morphine? | it is one tenth as potent as morphine
🗑
|
||||
| What is the lipid solubility of Meperidine (demerol) when compared to morphine? | 11x more lipid soluble than morphine
🗑
|
||||
| What percentage of meperidine is protein bound? | 60%
🗑
|
||||
| What is the dose of meperidine used to supplement anesthesia in pediatrics? | 0.5 - 1 mg/kg
🗑
|
||||
| What is the typical duration of meperidine? | 2 - 4 hours
🗑
|
||||
| Serotonin syndrome may be caused by interaction of meperidine with what drugs? | antidepressant MAO inhibitors
🗑
|
||||
| What are the symptoms of serotonin syndrome? | HTN, tachycardia, diaphoresis, hyperthermia, confusion, agitation, hyperreflexia; severe = coma, seizures, coagulopathy, metabolic acidosis
🗑
|
||||
| What is the distribution 1/2 time of fentanyl? | less than 28 minutes
🗑
|
||||
| Fentanyl is _______ lipid soluble | highly
🗑
|
||||
| What is fentanyl's potency in comparison to morphine? | 100x more potent than morphine
🗑
|
||||
| What is the typical dosage of fentanyl? | 1 - 2 mcg/kg
🗑
|
||||
| Small doses of fentanyl have a _______ duration related to ___________ | short (20 - 40 minutes); redistribution
🗑
|
||||
| Larger doses of fentanyl have a ________ duration related to ___________ | longer; acculumation
🗑
|
||||
| What percentage of the initial IV dose of fentanyl is taken up by the lungs? | 75%
🗑
|
||||
| Repeat doses of fentanyl accumulate in what 3 places? | muscle, fat, and lungs
🗑
|
||||
| What is the elimination 1/2 life of fentanyl? | 3.1 - 6.6 hours; but it has a clinically shorter duration than morphine r/t inactive metabolites
🗑
|
||||
| What percentage of IV dose of fentanyl leaves the plasma in less than 5 minutes? | 80%
🗑
|
||||
| How are plasma concentrations of fentanyl maintained? | through redistribution of drug back into plasma
🗑
|
||||
| Is elimination of fentanyl prolonged or lessened in the elderly? | prolonged; decrease the dose for the elderly
🗑
|
||||
| Is the elimination of fentanyl prolonged with hepatic cirrhosis? | No
🗑
|
||||
| What is the dosage of fentanyl when used as a balanced technique to blunt circulatory responses? | 2 - 20 mcg/kg IV
🗑
|
||||
| What dosage of fentanyl significantly reduces the dose of proposal needed for placement of an LMA? | 0.5 mcg/kg
🗑
|
||||
| Compare the MAC reduction of fentanyl to the MAC reduction of morphine | more effective in reducing MAC than morphine; ceiling effect 40% MAC reduction for small doses
🗑
|
||||
| What are 3 advantages of fentanyl? | no direct myocardial depression, no histamine release or displacement, suppresses stress response to surgery
🗑
|
||||
| What are 3 disadvantages of fentanyl? | sympathetic stimulation in response to pain, unreliable amnesia, post-op respiratory depression
🗑
|
||||
| Compare the CV effects of fentanyl to morphine. | fentanyl causes more of a decrease in heart rate than morphine
🗑
|
||||
| Doses of 30 mcg/kg of fentanyl change _______________ but do not interfere with the use and interpretation | SSEP or somatosensory evoked potential
🗑
|
||||
| Fentanyl use in head injury patients can cause a(n) _________ in ICP even with unchanged PaCO2 | increase
🗑
|
||||
| Fentanyl has a _________ drug interaction with benzodiazepines | synergistic
🗑
|
||||
| True or false: fentanyl has been known to cause reflex coughing in pre-op | True
🗑
|
||||
| Which is the most potent opioid currently available? | Sufentanil; 10x more potent than fentanyl and 1000x more potent than morphine
🗑
|
||||
| What percentage of sufentanil is taken up by the lungs? | 60%
🗑
|
||||
| What is the elimination 1/2 life of sufentanil? | 2.5 hours
🗑
|
||||
| A pre-induction dose of sufentanil may cause ________ but not ________________ | apnea; loss of consciousness
🗑
|
||||
| Stiff chest syndrome is common with sufentanil doses of _______ prior to induction | 10 - 15 mcg
🗑
|
||||
| Sufentanil has a _____ intense, _______ lasting analgesia than fentanyl with _____ respiratory depression | more; longer; less
🗑
|
||||
| What is the MAC reduction possible with Sufentanil? | up to 70%
🗑
|
||||
| Describe the dosing for an infusion of Sufentanil? | loading dose of 1 mcg/kg and then infusion rate of 1 mcg/kg/hr
🗑
|
||||
| When would the CRNA need to turn off an infusion of Sufentanil to ensure proper awakening? | 30 - 45 minutes prior to emergence
🗑
|
||||
| After infusion for 3 hours, sufentanil will decrease ____ more rapidly than fentanyl and alfentanil | 80%
🗑
|
||||
| After infusion for 8 hours, sufentanil will decrease ____ more rapidly than fentanyl or alfentanil | 50%
🗑
|
||||
| What is the potency of alfentanil when compared to fentanyl? | 1/5th as potent as fentanyl
🗑
|
||||
| What is the elimination 1/2 life of fentanyl | 1.1 - 1.6 hours
🗑
|
||||
| Alfentanil is not as lipid soluble as fentanyl, however only ___ ionized form at physiologic pH | 10%; this causes faster onset or effect site equilibration
🗑
|
||||
| Which opioid is the best choice for a single, brief stimulus? | alfentanil (examples = laryngoscopy, restrobulbar block)
🗑
|
||||
| 96% of alfentanil is cleared within ________________ | 60 minutes of administration
🗑
|
||||
| When should an infusion of alfentanil be discontinued in order to prevent delayed awakening? | 15 - 25 minutes prior to emergence
🗑
|
||||
| What is the dose of Alfentanil used for direct laryngoscopy? | 15 mcg/kg 90 seconds before blunts SBP and HR response; 30 mcg/kg blunts catecholamine response
🗑
|
||||
| What is the induction dose of alfentanil? | 150 - 300 mcg/kg given rapidly (risk of stiff chest syndrome)
🗑
|
||||
| What is the elimination half time of remifentanil? | 6 - 10 minutes
🗑
|
||||
| How is remifentanil metabolized? | by non specific plasma and tissue esterases into inactive metabolites which are excreted by the kidneys
🗑
|
||||
| Hypothermia slows clearance of remifentanil by ____ | 20%
🗑
|
||||
| Compare alfentanil and remifentanil in terms of inter patient variability | alfentanil = BIG interpatient variability; remifentanil = little variability
🗑
|
||||
| What is the context sensitive half time of remifentanil? | 4 minutes; it is independent of infusion time
🗑
|
||||
| Remifentanil causes a ___ decrease in SNP two minutes after infusion | 30%
🗑
|
||||
| The rapid equilibration time of remifentanil means what in terms of titrability? | easily titrated
🗑
|
||||
| What are 4 clinical uses for remifentanil? | laryngosopy, retrobulbar block, L&D, rapid recovery desired (craniotomy, carotid endarterectomy)
🗑
|
||||
| Which opioid comes in powder form and must be reconstituted? | remifentanil
🗑
|
||||
| What is the induction dosing of remifentanil? | 1 mcg/kg over 60 - 90 seconds or 0.5 - 1 mcg/kg prior to IV anesthetic agent
🗑
|
||||
| What is the remifentanil dose used for monitored anesthesia care (MAC)? | 0.05 - 0.1 mcg/kg/min with midazolam (versed)
🗑
|
||||
| 1.5 mg of hydromorphone is equivalent to ___ of morphine or ___ of fentanyl | 10 mg of morphine; 100 mcg of fentanyl
🗑
|
||||
| What is the dose of hydromorphone? | 0.02 - 0.06 mg/kg
🗑
|
||||
| What is the onset of hydromorphone? What is the duration? | onset: 5 minutes; duration: 4 - 5 hours
🗑
|
||||
| Which drug is better for renal failure patients and why: morphine or hydromorphone? | hydromorhpone because it has inactive metabolites
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
Mary Beth
Popular Pharmacology sets