Anticancer drug
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| Curative cancer by chemotherapy | choriocarcinoma (advance stage); Hodgkin's disease, carcinoma of tests; acute leukemia (some case)
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| Biologic therapy | immunotherapy (involves stimulating the host's immune system to fight the cancer)
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| Agent of Biologic therapy | cytokines (Produce by DNA tech). tumor vaccines; interferons (IFNs); interleukins (ILs); monoclonal antibodies (mAbs)
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| Adjuvant therapy | the use of systemic agents to eradicate micrometastatic disease following localized modalities such as surgery and radiation or both.
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| Palliative therapy | relieving and preventing the suffering of patients
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| Alkylating agents | Nitrogen mustards; ethylenimine & methylmelamines; alkyl sufonates; nitrosourea; triazenes and platinum complexes
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| Antimetabolites | folic acid analogs; pyrimidine analogs and purine analogs
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| Natural products | anti mitotic drugs; epipodophyllotoxins; camptothecin analogs; antibiotics
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| Hormones and antagonists | estrogens; androgens and their antagonists (tamoxifen, flutamide)
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| Miscellaneous agents | substituted urea (hydroxyurea); enzymes; tyrosine kinase inhibitors; monoclonal Abs
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| Factor affect chemotherapy | drug resistance; tumor cell heterogeneity; does intensity; patient-specific factors
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| Drug resistance | 1) decrease activation of drug; 2) decrease drug uptake or incase efflux; 3) change in target enzymes; 4) increase repair ability of cell damage; 5) increase drug inactivation
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| Drug resistance protein | MRP (ABCC); BCRP (ABCG2/MXRABCP)
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| General inhibitors of organic anion transport | Probeanecid; sulfinpyrazone; indomethacin
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| Inhibitors or P-glycoprotein and MRPs | PAK104P; Verapamil; cyclosporinA; genistein; MK571; ONO1078; TKI
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| GSH-dependent inhibitors of MRP1 | AgosteolA; LY475776; LY402913
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| Inhibitors of ABCG2/BCRP | Fumitremorgin C(FTC); GF120918; TKIs
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| Taxanes, Paclitaxel (Taxol) | Ovarian carcinoma
MOA: Promotes microtubule formation, inhibits the replication and also enhance the radiation therapy.
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| Docetaxel (Doc, Taxotere, TXT) | It is analog of Taxol. Breat, ovarian cancer; NSCLC
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| Camptothecin's analog, topotecan | Advance ovarian carcinoma, some efficacy on lung cancer.
MOA: inhibits topoisomerase I
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| Irinotecan (CPT-11) | metastatic colorectal cancer.
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| Small molecule compounds (TK inhibitors) | Imatinib mesylate (Gleevec, ST1571); Gefitinib (Iressa, ZD1839); Erlotinib (Taceva); Sutent (sunitinib malate, formerly SU-11248); Trastuzumab (Herceptin); Lapatinib or lapatinib ditosylate (GW572016); Dasatinib (Sprycel); Nilotinib (Tasigna)
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| Imatinib mesylate (Gleevec, STI571) | Chronic myelogenous leukemia (CML); Gastrointestinal stromal tumor (GIST)
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| Gefitinib (Iressa, ZD1839) | NSCLS
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| Erlotinib (Tarceva) | NSCLS
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| Sunitinib malate (SU11248) suttent | MOA: TKis, also inhibiting blood vessel growth
renal cel carcinoma
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| Trastuzumab (Herceptin) | breast cancer
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| apatilnib ditosylate, GW572016) | breast and lung cancer
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| Dasatinib (Sprycel) | chronic phase (CP) accelerated phase (AP) myeloid blast (MB) lymphoid blast (LB) Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML)
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| Nilotinib (Tasigna) | drug resistant chronic myelogenous leukemia (CML)
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| Everolimus (Afinitor) | Kidney cancer
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| Bevacizumab (Avastin) | colon cancer; NSCLC; breast cancer
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| Crizotinib (Xalkori, Pfizer) | NSCLC
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| Vemurafenib (Zelboraf) | melanoma
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| Nanoparticle albumin-bound (nab)-paclitaxel (Abraxane, Celgene) | metastatic pancreatic cancer
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| Bevacizumab (Avastin) | last stage cervical cancer
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| Nivolumab | melanoma
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| Pembrolizumab | melanoma
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| Beleodaq (belinostat) | peripheral T-cell lymphoma
MOA: Histone deacetylase (HDAC) inhibitor
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| Vectibix (panitumumab) | metastatic colorectal cancer
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| Imbruvica (ibrutinib) | chronic lymphocytic leukemia
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| Zydelig (idelalisib) | chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL)
MOA: phosphoinositide 3-kinase (PI3K) delta inhibitor
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| Velcade (bortezomib) | multiple myeloma
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| Avastin (bevacizumab) | cervical cancer
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Created by:
wind1980
Popular Pharmacology sets