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Effects/ Complications

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Term
Definition
High Potency Neuroleptics   Low Sedation Low Anticholinergic Effects High Extrapyramidal Symptoms  
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Low Potency Neuroleptics   High Sedation High Anticholinergic Effects Low Extrapyramidal Symptoms  
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Extrapyramidal Symptoms   Acute Dystonia - Rigid Movements Akathisia - Fidgity Pseudo Parkinsonism Masklike Faces - Tremors Drooling Pill Rolling Shuffling Gait  
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Tardive Dyskinesia   Involuntary Muscle Spasms Periorbital Movements (Oculogyric Crisis) Tongue Protrusion Rocking Abnormal Invouluntary Movement Scale (Aims)  
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Dystonia   Retrocollis or Torticollis Trismus - Gaping Or Grimacing Dysphagia - Laryngeal/Pharyngeal Spasm Or Dysphonia Macroglossia Tongue Protrusion or Tongue Dysfunction Abnormal Positioning Of Distal Limbs Or Trunk  
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Atypical/Noval Antipsychotics   Tx Positive Symptoms  
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Neuroleptic Malignant Syndrome (NMS)   Acute Decrease In Brain Dopamine Severe Muscle Rigidity Hyperpyrexia - fever Labile Hypertension - fluctuating BP Tachycardia (>130 Bpm) Tachypnea (>25 Rpm) Diaphoresis, Pallor Delirium …Change In Mental Status  
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NMS Treatment   Discontinuation Of Neuroleptic Creatine Kinase (CK) To Determine Muscle Injury Maintain Hydration Decrease Temperature Arrhythmias Should Be Treated Bromocriptine May Relieve Rigidity Dantrolene May Decrease Spasms  
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Atypical Antipsychotics: Metabolic Syndrome Risk Increase with... (Except Aripiprizole and Ziprasidone)   fasting glucose fasting lipid profile abdominal girth, weight, NI: BP monitored at least quarterly during the first year and yearly thereafter  
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Second Gen or Atypical Antipsychotics Challenges   Weight gain and metabolic abnormalities  
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