Coritcosteriods
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stimulate gluconeogenesis in the liver and decrease uptake of glucose into the muscle, lymphatic, and adipose cells results in | elevated glucose
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decreased proliferation of fibroblasts in connective tissue in concert with poor protein synthesis leads to | poor wound healing
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highest mineralocorticoid potency (aldosterone) | cortisone, hydrocortisone
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moderate mineralocorticoid potency | prednisone, prednisolone, florinef
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low mineralocorticoid potency | triamcinolone, dexamethasone, methylprednisolone, betamethasone
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high mineralocorticoid potency drugs can cause | elevated BP, salt and water retention, increased excretion of potassium
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all corticosteroids increase excretion of | calcium, can create problems for postmenopausal women or others at risk for osteoporosis
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pregnancy category | C: have caused cleft palate, stillborn, decreased fetal size
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glucocorticoids at 7.5mg/day or > for > 6 months can cause | rapid loss of trabecular bone in the spine, hip, and forearm
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if risk factors of PUD recommended prophylaxis | PPI's or h2 blockers
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primary and secondary adrenocortical insufficiency | primary no common is US; secondary more common due to steroid withdrawal
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choice for treating inflammation, ? mineralocorticoid potency | low, methylprednisolone, dexamethasone
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use for immunosuppression most commonly | prednisone
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if used for rheumatoid arthritis at < 7.5 mg/d for short term use supplement with | bisphosphonate (Fosamax), and calcium, vit. d supplements
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for chronic corticosteroid therapy dosing may be | every other day to help minimize HPA axis suppression
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to best match natural body rhythm, diurnal, take medication before what time | 9 am
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signs of adrenal insufficiency | anorexia, nausea, weakness, fatigue, dyspnea, hypotension, hypoglycemia
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