Gout
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Antigout drugs mechanism | reduce inflammatory process,or prevent synthesis of uric acid
🗑
|
||||
| Inhibit xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine and xanthine to uric acid | Allopurinol (Zyloprim), febuxostat (Uloric)
🗑
|
||||
| The only drugs that act on the pathophysiological cause of gout | Allopurinol (Zyloprim), febuxostat (Uloric)
🗑
|
||||
| Goal is to have uric acid less than | 6mg/dL
🗑
|
||||
| Binds to microtubular proteins to interfere with the function of the mitotic spindles and inhibit the migration of granulocytes to the inflamed area | Colchicine
🗑
|
||||
| actions decrease the inflammatory response to the deposited urate crystals | Colchicine
🗑
|
||||
| not uricosuric and does not prevent gout from progressing to chronic gouty arthritis | Colchicine
🗑
|
||||
| Increase the rate of uric acid secretion | uricosuric drugs
🗑
|
||||
| uricosuric drugs | probenicid, sulfinpyrazone
🗑
|
||||
| Sulfa based and should not be used in the case of sulfa allergy | uricosurics
🗑
|
||||
| contraindicated in patients taking drugs requiring xanthine oxidase (Imuran, mercaptopurine, theophylline) | Febuxostat (Uloric)
🗑
|
||||
| associated with maculopapular skin rash, scaly, exfoliative, drug should be discontinued | Allopurinol (Zyloprim)
🗑
|
||||
| induces reversible malabsorption of B12 | colchicine
🗑
|
||||
| Antigout drugs mechanism | reduce inflammatory process,or prevent synthesis of uric acid
🗑
|
||||
| Inhibit xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine and xanthine to uric acid | Allopurinol (Zyloprim), febuxostat (Uloric)
🗑
|
||||
| The only drugs that act on the pathophysiological cause of gout | Allopurinol (Zyloprim), febuxostat (Uloric)
🗑
|
||||
| Goal is to have uric acid less than | 6mg/dL
🗑
|
||||
| Binds to microtubular proteins to interfere with the function of the mitotic spindles and inhibit the migration of granulocytes to the inflamed area | Colchicine
🗑
|
||||
| actions decrease the inflammatory response to the deposited urate crystals | Colchicine
🗑
|
||||
| not uricosuric and does not prevent gout from progressing to chronic gouty arthritis | Colchicine
🗑
|
||||
| Increase the rate of uric acid secretion | uricosuric drugs
🗑
|
||||
| uricosuric drugs | probenicid, sulfinpyrazone
🗑
|
||||
| Sulfa based and should not be used in the case of sulfa allergy | uricosurics
🗑
|
||||
| contraindicated in patients taking drugs requiring xanthine oxidase (Imuran, mercaptopurine, theophylline) | Febuxostat (Uloric)
🗑
|
||||
| associated with maculopapular skin rash, scaly, exfoliative, drug should be discontinued | Allopurinol (Zyloprim)
🗑
|
||||
| induces reversible malabsorption of B12 | colchicine
🗑
|
||||
| treatment of acute gouty attacks | colchicine initial dose 1.2mg, followed by 0.6 mg one hour later, symptoms usually resolve in 24-48 hours
🗑
|
||||
| preventive therapy with colchicine | 0.6mg/day 3-4x/week if pt has fewer than one attack per year; 0.6 daily for more frequent attacks
🗑
|
||||
| drug of choice for h/o urinary calculi, renal insufficiency, chronic tophaceous gout, or high levels of serum urate | allopurinol, mild 200-300 mg/day; moderate 400-600mg/day. Minimum dose 100-200; Maximum dose, 800. Doses > 300 must be divided
🗑
|
||||
| best for pts who overproduce uric acid | allopurinol (Zyloprim), febuxostat (Uloric)
🗑
|
||||
| best for pts who undersecrete uric acid | probenecid
🗑
|
||||
| toxicity seems more likely when allopurinol is given concomitantly with | thiazide diuretics
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
heatherbrown2020
Popular Pharmacology sets