CHEM 183 MT1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Who discovered chloroform and around what time? | James Simpson 1847
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| What chemical compound does a polyester bottle harbour? | Antimony
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| Nowadays, what is the smallest ratio (example: part per billion) detectable by laboratory machines? | Part per trillion
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| What does ADI stands for? What does it mean? | Acceptable Daily Intake. The lowest dose taken each day for your whole life without developing any problems.
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| What does NOAEL stands for? | No Observed Adverse Effect Level
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| How do scientist calculate the ADI? | NOAEL / 100
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| Definition of Hazard | Fixed property that cannot be altered
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| Definition of Risk | Risk = Hazard x Exposure x Vulnerability x Toxicity
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| What does URARI mean? | He to whom it comes, falls
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| Who saw the monkey killed by the 'Three tree' poison? | Sir Walter Raleigh
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| What vine does the URARI (Curare) comes from? | Chondodendron tomentosum
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| What did Charles Waterton realize in 1810's? | Realized that Curare in the right dose could cause muscle relaxation without death
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| Who realized that Curare, in the appropriate dose, could be a muscle relaxant without killing the patient? | Charles Waterton in 1812
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| What did Claude Bernard understood about the Curare mechanism? (1840's) | That it blocks the nerve impulses from the brain to the muscles.
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| What is the name of the chemical molecule of Curare? | Tubocuranine
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| What did Dr. Harold Griffith did? | He was the first physician to use Curare to relax the muscles of a patient undergoing a surgery
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| Who was the first physician to use Curare to relax the muscles of a patient undergoing an appendectomy in 1940's? | Dr. Harold Griffith
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| Who did something so amazing that we started calling pre X era and post X era? | Dr. Harold Griffith; Pre Griffith era and post Griffith era.
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| What is the name of the synthetic upgrade of Curare? | Pavulon
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| Which compounds are used in the death penalty? | Sodium thiopentol (sleep), Pavulon (breath), Potassium chloride (heart)
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| When was liquid sulfanilamide put on the market? | 1930's
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| What did Harold Watkins do? | He was the chemist that used diethylene glycol as sulfanilamide's solvent. He committed suicide when he heard what his product did to the population.
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| Who was the scientist that used diethylene glycol as a solvent? | Harold Watkins
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| What is Kemps Basalm? | Kind of remedy used during the 1911 flu but not very useful.
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| What is the Trypanosoma cruzi? | It is the scientific name of the parasite of the kissing disease or Chagas Disease.
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| How can we control a Trypanosoma Cruzi? | Ingest a molecule that suppresses a cysteine protease, crucial for the parasite
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| Who was Sir William Osler? | Started medical education in North America with McGill and John Hopkins. Listen to the patient, he will tell you the diagnosis (1870's)
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| What is a Drug? | Chemical agent that affects living matter
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| What are smelling salts made of? | Ammonium Carbonate
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| Who were the two doctors know for writing about the practice of medicine, in the 1130's - 1200's? | Avicenna and Maimonides
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| What is ABT-594 and where can we find it? | It is a compound 200 times more effective than morphine at preventing pain, is non-addictive. Found on Panamanian frog.
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| Who was Jakob Bohme? | Established the Doctrine of Signatures, influenced by Hegel and Schopenhauer
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| What is a Bezoar Stone and what was it cured? | It is kidney stones from goats and apparently cured Black Plague.
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| Name one emetic and say what it does? | Ipecac, induces vomiting instantaneously.
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| Why is Aconite known? | Because it was the poison used in Romeo and Juliet.
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| What is used for failing heart (CHF) and is derived from foxglove plant? | Digoxin
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| What did William Withering published? | 'A botanical arrangement of all the vegetables growing in Great Britain' and the first medical articles ever on the foxglove
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| Where does Quinine comes from and why is it used? | It is an alkaloid that comes from the bark and leafs of the Cinchona plant and is used against Malaria.
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| What did Pelletier and Caventou do? | They were the 1rst to efficiently purify Quinine from Cinchona bark
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| To what is DDT toxic? | To Birds, it causes bird eggs to crack prematurely.
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| What is the other name for Syphilis? | 'The Great Pox' 1490's
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| What did Samuel Hahnemann do? | Proposed the essence and foundation of Homeopathy
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| Who purified morphine at the start of the 1800'th century? | Friedrich Serturner
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| What did Joseph Lister brought to the medical knowledge? | He first started spraying phenol in the air during an operation to reduce infections, but switched it to washing hands and wearing gloves. Named Listerine after him.
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| Who was the man that McGill named the Roddick Gate after? | He introduced Antisepsis in Canada
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| From what molecule structure is phenol has many differences? | Thymol (desinfectant), Propophol (milk of amnesia) and BHT (antioxydant)
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| What was Salicylic acid used for and what was his main problem? | Was used in acne solution and warts and his main problem was stomach irritation
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| Who is Felix Hoffman? | In the 1890's, he discovered the aspirin for his dad because he had arthritis and found that salicylic acid was bitter sweet.
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| What does COX stand for? | CyclOoXygenase
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| What are prostaglandin? | Pain messenger
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| Who was John Vane? | He was the scientist that gain a Nobel Prize for explaining the prostaglandin's mechanism
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| What does NSAID stands for? | Non steroidal anti-inflammatory drugs
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| What is the other name for acetaminophen? | Paracetamol
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| What is rofecoxib? | Also called Vioxx, it is an anti-inflammatory drug that is COX-2 selecting but increases the risks of heart disease
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| What is the opposite of the Placebo effect? | The Nocibo effect
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| Who was Joseph Priestley? | He used laughing gaz
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| What did Crawford Williamson do in the 1840's? | He succeeded the first sirurgie with anaesthetics (2 tumors) but published his findings only 6 years after.
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| What did Horace Wells used as an anaesthetic? | Laughing gas (N2O)
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| What was the name and the other name given by William T. G. Morton to his anaesthetic? | He used ether but named it Letheon
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| Who was John Collins Warren? | Most famous surgeon of USA. Realized a successful operation using ether as anaesthetic.
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| Why was there a controversy over Queen Victoria in the 1850's? | She got anaesthetize by John Snow when giving birth to her 8th children.
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| What is Fentanyl? | It is an intravenous anaesthetic 100 times more powerful than morphine and possess a half-life time of 5h
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