Cholinergic and Adrenergic Receptors
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each of the black spaces below before clicking
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heart: SA node; AV node | M2 | decrease HR; ; decrease conduction velocity
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GI tract: glands | M1 | secretion
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sphincters | M3 | relax, except LES, which contracts
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blood vessels (endothelium) | M3 | dilation (via NO/EDRF)--no innervation; no effects of indirect agonists
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adrenal medulla | NN | secretion of epinephrine and NE
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autonomic ganglia | NN | stimulation; net effects depend on PANS/SANS innervation & dominance: SANS in arterioles, veins, sweat glands
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neuromuscular junction | NM | stimulation--twitch/hyperactivity of skeletal muscle
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eye--radial muscle | a1 | contraction--mydriasis
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arterioles (skin, viscera) | a1 | contraction--increase TPR
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prostate | a1 | contraction--urinary retention
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prejunctional nerve terminals | a2 | decrease transmitter release and NE synthesis
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pancreas | a2 | decreased insulin secretion
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heart | B2 | increase HR; increase conduction velocity, conduction velocity, force of contraction
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kidney | B2 | increase renin release
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blood vessels (all) | B2 | vasodilation--decrease TPR
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uterus | B2 | relax--inhibit labor
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pancreas | B2 | increase insulin secretion
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renal, mesenteric, coronary vasculature | D1 | vasodilation--in kidney: increase GFR, RBF, Na+ excretion
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CNS | M1 | excitation
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Created by:
PittDave
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