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Cholinergic and Adrenergic Receptors

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Target
Receptor
Response
heart: SA node; AV node   M2   decrease HR; ; decrease conduction velocity  
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GI tract: glands   M1   secretion  
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sphincters   M3   relax, except LES, which contracts  
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blood vessels (endothelium)   M3   dilation (via NO/EDRF)--no innervation; no effects of indirect agonists  
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adrenal medulla   NN   secretion of epinephrine and NE  
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autonomic ganglia   NN   stimulation; net effects depend on PANS/SANS innervation & dominance: SANS in arterioles, veins, sweat glands  
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neuromuscular junction   NM   stimulation--twitch/hyperactivity of skeletal muscle  
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eye--radial muscle   a1   contraction--mydriasis  
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arterioles (skin, viscera)   a1   contraction--increase TPR  
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prostate   a1   contraction--urinary retention  
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prejunctional nerve terminals   a2   decrease transmitter release and NE synthesis  
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pancreas   a2   decreased insulin secretion  
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heart   B2   increase HR; increase conduction velocity, conduction velocity, force of contraction  
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kidney   B2   increase renin release  
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blood vessels (all)   B2   vasodilation--decrease TPR  
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uterus   B2   relax--inhibit labor  
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pancreas   B2   increase insulin secretion  
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renal, mesenteric, coronary vasculature   D1   vasodilation--in kidney: increase GFR, RBF, Na+ excretion  
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CNS   M1   excitation  
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Created by: PittDave
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