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CVS Pharmacology Matching
Examples of ACEIs used for vasodilators
Captopril Enalapril Lisinopril
Examples of Cyclic AMP Dependant Agents:
B-adrenergic Agonists Phosphodiesterase Inhibitors
How is digitalis toxicity treated?
Reduce or stop the drug Cardiac pacemeker for heart block Digitalis antibodies Arrhythmias may be converted to normal sinus rhythm by K+ Antiarrhythmic drugs, such as lidocaine, phenytoin, procainamide, or propranolol, used when K+ conc is high
What is the therapeutic value of ACEIs?
DOC in HF No tolerance Retard progression of HF Decrease arrhythmias Only drugs which decrease mortality, but only when the highest tolerated doses are used
What are the causes of diuretic resistance in HF?
Noncompliance with regimen Excess dietary Na+ intake Decreased renal perfusion and GFR Selective reduction in glomerular perfusion pressure following initiation of ACEI therapy NSAIDs Primary renal pathology Reduced or impaired diuretic absorption
Nonselective a-adrenergic antagonists used for vasodilators:
Phentolamine
Examples of phosphodiesterase inhibitors (which are cAMP dependent agents):
Amrinone Inamrinone Milrinone Vesanirone Sildenafil Adorable Ideas Meet Slimy Verbs
Major contributing factor to digoxin toxicity
K+-depleting diuretics
How do positive inotropic agents increase force of contraction?
By increasing intracellular cardiac Ca++ concentration
Toxicity, as a result of phosphodiesterase inhibitors leads to:
Arrhythmias Thrombocytopenia
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