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CVS Pharmacology Matching
Phosphodiesterase inhibitors used for vasodilators:
Milrinone Inamrinon
Examples of Nitric oxide donors used for vasodilators
Nitroprusside
How are Beta blockers administered?
Started with low doses and gradually increased
What are the causes of diuretic resistance in HF?
Noncompliance with regimen Excess dietary Na+ intake Decreased renal perfusion and GFR Selective reduction in glomerular perfusion pressure following initiation of ACEI therapy NSAIDs Primary renal pathology Reduced or impaired diuretic absorption
Examples of Cyclic AMP Independent Agents:
Digitalis Pimobendan
Objectives of Long Term Management of Chronic Cardiac Failure:
Improve cardiac performance at rest and during exercise Relieve symptoms Improve myocardial efficiency Improve quality of life (particularly symptom-free and effort tolerance) Improve patient survival
When are beta blockers contraindicated?
In severe, refractory, or unstable cases
Examples of Digitalis glycosides:
Digitalis purpura Digitalis lanata Strophanthus
How do positive inotropic agents increase force of contraction?
By increasing intracellular cardiac Ca++ concentration
Pharmacological and toxic effects are greater in
Hypokalemic patients
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