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SK Biochem
AAA Biochem
| Question | Answer |
|---|---|
| Vmax | Maximal velocity of an enzyme catalyzed rxn |
| Km | the amt of substrate required to reach 1/2Vmax |
| What happens to Km and Vmax with a competitive inhibitor | Incr. Km and No change in Vmax |
| What happens to Km and Vmax with a non-competitive inhibitor | No change in Km and Decr. in Vmax |
| Thiamine AKA | B1 |
| Riboflavin AKA | B2 |
| Niacin AKA | B3 |
| Pantothenate AKA | B5 |
| Pyridoxine AKA | B6 |
| Biotin AKA | B7 |
| Cobalamin AKA | B12 |
| Thiamine B1 Active form (enzyme) | Thiamine Pyrophosphate TTP |
| Riboflavin B2 Active form (enzyme) | FAD and FMN (KREBS) |
| Niacin B3 Active form (enzyme) | NAD and NADP (KREBS) |
| Pantothenate B5 Active form (enzyme) | CoA |
| Pyridoxine B6 Active form (enzyme) | Pyridoxal Phosphate |
| Biotin B7 Active form (enzyme) | Bioctivin |
| Folic Acid Active form (enzyme) | Tetrahydrofolate |
| Cobalamin B12 Active form (enzyme) | Methylcobalamin |
| Thiamine B1: What reaction is this vit used in? | Decarboxylation |
| Riboflavin B2: What reaction is this vit used in? | Redox Rxn |
| Niacin B3: What reaction is this vit used in? | Redox Rxn (Glycolysis) |
| Pyridoxine B6: What reaction is this vit used in? | Transaminations (amino acid metabolism) |
| Biotin B7: What reaction is this vit used in? | Carboxylations |
| Folic Acid: What reaction is this vit used in? | Onc C transfers |
| Vit C: What reaction is this vit used in? | Hydroxylation of Proline, Lysine in collagen |
| Thiamine B1: Disease | Beri Beri Alcoholics Wernickes Korsakoffs Syndrome |
| Riboflavin B2: Disease | Chelosis (cracked corners of mouth) Magenta Tongue |
| Niacin B3: Disease | Pellegra (4D's): Dermatitis Diarrhea Dimentia Death |
| Pantothenic Acid B5: Disease | Burning Foot Syndrome |
| Pyridoxine B6: Disease | Infants- Convulsions Adults- Anemia |
| Biotin B7: Disease | Glossitis Dermatitis |
| Folic Acid: Disease | Megaloblastic/Macrocytic Anemia |
| Cobalamin B12: Disease | Pernicious/Macrocytic Anemia |
| Vit C: Disease | Scurvy |
| Fat Soluble Vits | ADEK |
| Vit A: Co-enzyme | Retinoic Acid |
| Vit D: Co-enzyme | 1,25-Dihydroxycholecalciferol |
| Vit E: Stored in | Adipose, Liver and Muscle |
| Vit E: Requires what for absorption | Bile salts and fat |
| Vit K: Stored in | Liver and Spleen |
| Vit K AKA | Quinone |
| Vit E AKA | Tocopherol |
| Vit D AKA | Cholecalciferol |
| Vit A: Fxn | Vision, growth |
| Vit D: Fxn | Absorbs calcium from gut, Calcium and phosphate metabolism |
| Vit E: Fxn | Lipid AOX |
| Vit K: Fxn | Makes prothrombin in liver, Blood clotting, precursor to Co-Q |
| Vit A: Disease | Night blindness, Bitot spots |
| Vit D: Disease | Kids: Rickets (bow legs) Adults: Osteomalacia (Bone soft) |
| Vit E: Disease | Hemolytic Anemia, Muscular dystrophy, sterility |
| Vit K: Disease | Clotting disorders |
| Calcium: Fxn | Component of Bone, Musc contraction, Nerve regulation |
| Calcium: Regulated by | Vit D: Gut --> Blood CalcitonIN: Blood --> Bone PTH: Bone --> Blood (Parathyroid) |
| Calcium: Deficiency & Toxicity | Decr: Rickets, Osteomalacia, Tetany Incr: Reduced musc tone, Ca deposits in soft tissue, Renal fail |
| Phosphorus: Fxn | Found in bone, ATP, Nucleic Acids |
| Phosphorus: Regulated by | Kidney |
| Phosphorus: Deficiency & Toxicity | Decr: Rickets, Osteomalacia, renal dysfunction Incr: Bone loss |
| Sodium: Fxn | H2O distribution, osmosis, AP, Bicarb |
| Sodium: Regulated by | Aldosterone |
| Sodium: Deficiency & Toxicity | Decr: HYPOnatremia, confusion, coma Incr: HYPERtension |
| Potassium: Fxn | Nerve and musc AP |
| Potassium: Regulated by | Aldosterone |
| Potassium: Deficiency & Toxicity | Decr: Musc weakness Incr: Cardiac arrest |
| Chlorine: Fxn | H2O balance |
| Chlorine: Deficiency & Toxicity | Secondary to vomit |
| Magnesium: Fxn | Found in Bone Co-factor of Kinase Needed for Glucose Breakdown |
| Magnesium: Deficiency & Toxicity | Decr: Diabetes, HYPERtension, increases blood cholesterol, spasms BVs Incr: Poisoning (like Parkinsons) |
| Chromium: Fxn | Glucose transport Helps bind Insulin to cell |
| Chromium: Disease | Impaired glucose tolerance |
| Cobalt: Disease | Macrocytic/Pernicious Anemia |
| Copper: Fxn | Part of ETC Transported by Albumin Melanin Formation |
| Copper: Disease | Menke's Syndrome (CNS, die in infancy) |
| Iodine: Fxn | Part of Thyroxine Stored as Thyroglobulin in thyroid |
| Iodine: Disease | Kid: Creatinism Adults: Goiter, Myxedema |
| Iron: Fxn | Part of heme, hemoglobin, cytochromes Transported as: TRANSferrin Stored as: FerriTIN |
| Iron: Disease | Hypochromic/Microcytic Anemia |
| Manganese: Fxn | Co-factor of decarboxylase Hemoglobin Forms Urea Growth Reproduction |
| Manganese: Disease | Ligamentous healing |
| Selenium: Fxn | Co-factor of Glutathione Peroxidase Synergistic with Vit E |
| Selenium: Disease | Decr: Cardiomyopathy Incr: Hair/Nail loss |
| Zinc: Fxn | Co-factor of Carbonic anhydrase |
| Zinc: Disease | Neuro damage, impaired wound healing |
| Flourine: Fxn | Increases hardness of teeth |
| Flourine:Disease | Dental caries |
| Which enzyme family functions in moving hydrogen | Oxidoreductase |
| Which enzyme family has the cofactors: NAD/FAD/NADP | Oxidoreductase |
| Which enzyme family does G3P Dehydrogenase belong in? | Oxidoreductase |
| Which enzyme family does any enzyme with the ending "dehydrogenase" belong in | Oxidoreductase |
| Which enzyme family functions in splitting molecules into two by adding water? | Hydrolase |
| Which enzyme family is found in most of the digestive system? | Hydrolase |
| Which enzyme family ends in "ase" | Hydrolase |
| Which enzyme family joins two molecules together | Ligase |
| Which enzyme family is ATP synthetase an example of? | Ligase |
| Which enzyme family transfers a phosphate | Kinase |
| Which enzyme family has the cofactors ATP and Mg | Kinase |
| Which enzyme family is Hexokinase an example of? | Kinase |
| Which enzyme family Transers an amino group? | Aminotransferase |
| Which enzyme family has a cofactor of Vit B6 | Aminotransferase |
| Which enzyme family is SGPT and SGOT an example of? | Aminotransferase |
| Which enzyme family transfers a hydroxyl group | Hydroxylase |
| Which enzyme family has cofactors Vit C, Cu and Fe | Hydroxylase |
| Which enzyme family removes or adds a carboxylase | Decarboxylase/Carboxylase |
| Which enzyme family has biotin as cofactor | Decarboxylase/Carboxylase |
| Which enzyme family has pyruvate carboxylase as an example | Decarboxylase/Carboxylase |
Created by:
SanaK
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