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USMLE Antidotes

Specific antidotes to toxins/overdoses

QuestionAnswer
Acetaminophen Antidote? N-acetylcysteine
Salicylates Antidote? NaHCO3 (alkalinize urine), dialysis
Amphetamines (basic) Antidote? NH4CL (Acidify urine)
AchE Inhibitors, Organophosphates Antidote? Atropine + Pralidoxime
Antimuscarinic, Anticholinergic Agents Antidote? Physostigmine salicylate
B-Blockers Antidote? Glucagon
Digitalis Antidote? Stop dig, normalize K+, Lidocaine, Anti-dig Fab fragments, Mg2+
Iron Antidote? Deferoxamine
Lead Antidote? CaEDTA, dimercaprol, succimer, penicillamine.
Mercury, arsenic, gold Antidote? Dimercaprol (BAL), succimer
Copper, Arsenic, gold Antidote? Penicillamine
Cyanide Antidote? Nitrite, hydroxocobalamin, thiosulfate
Methemoglobin Antidote? Methylene blue, Vit C
Carbon monoxide Antidote? 100% O2, hyperbaric O2
Methanol, ethylene glycol (Antifreeze) Antidote? Ethanol, dialysis, Fomepizole
Opioids Antidote? Naloxone/Naltrexone
Benzodiazepines Antidote? Flumazenil
TCAs Antidote? NaHCO3 (plasma alkalinization
Heparin Antidote? Protamine
Warfarin Antidote? Vit K, Fresh frozen plasma
tPA, streptokinase Antidote? Aminocaproic Acid
Theophylline Antidote? B-blocker
Created by: celaschiac
 

 



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