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Bio - ch 11
| Question | Answer |
|---|---|
| 1) Using the yeast signal transduction pathways, both types of mating cells release the mating factors. These factors bind to specific receptors on the correct cells, | which induce changes in the cells that lead to cell fusion. |
| 2) What is most likely to happen to an animal's target cells that lack receptors for local regulators? | They might not be able to multiply in response to growth factors from nearby cells. |
| 4) Which of the following is characterized by a cell releasing a signal molecule into the environment, followed by a number of cells in the immediate vicinity responding? | paracrine signaling |
| 9) When a neuron responds to a particular neurotransmitter by opening gated ion channels, the neurotransmitter is serving as which part of the signal pathway? | signal molecule |
| 11) Which of the following is true for the signaling system in an animal cell that lacks the ability to produce GTP? | It would not be able to activate and inactivate the G protein on the cytoplasmic side of the plasma membrane. |
| 12) Testosterone functions inside a cell by | binding with a receptor protein that enters the nucleus and activates specific genes. |
| 13) Which of the following is true of transcription factors? | They control gene expression. |
| 14) One of the major categories of receptors in the plasma membrane reacts by forming dimers, adding phosphate groups, and then activating relay proteins. Which type does this? | receptor tyrosine kinases |
| 15) Because most receptors are membrane proteins, which of the following is usually true? | They change their conformation after binding with signal polypeptides. |
| 16) Since steroid receptors are located intracellularly, which of the following is true? | The steroid/receptor complex can cross the nuclear membrane. |
| 19) In general, a signal transmitted via phosphorylation of a series of proteins | brings a conformational change to each protein. |
| 21) Which of the following is the best explanation for the inability of a specific animal cell to reduce the Ca2+ concentration in its cytosol compared with the extracellular fluid? | insufficient ATP levels in the cytoplasm |
| 23) Which of the following would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins? | receptor tyrosine kinase activity |
| 27) Caffeine is an inhibitor of phosphodiesterase. Therefore, the cells of a person who has recently consumed coffee would have increased levels of | cAMP. |
| 28) If a pharmaceutical company wished to design a drug to maintain low blood sugar levels, one approach might be to design a compound | to block G protein activity in liver cells. |
| 31) Which of the following statements is true of signal molecules? | Protein kinase A activation is one possible result of signal molecules binding to G protein-coupled receptors. |
| 34) Which of the following is the best explanation for the fact that most transduction pathways have multiple steps? | Multiple steps provide for greater possible amplification of a signal. |
| 36) The function of phosphatases in signal transduction is best described as to | inactivate protein kinases and turn off the signal transduction. |
| 37) What explains the increased concentration of Ca++ in the ER? | Calcium ions are actively imported from the cytoplasm into the ER. |
| 39) A drug designed to inhibit the response of cells to testosterone would almost certainly result in which of the following? | a decrease in transcriptional activity of certain genes |
| 40) At puberty, an adolescent female body changes in both structure and function of several organ systems, primarily under the influence of changing concentrations of estrogens and other steroid hormones. How can one hormone mediate so many effects? | Estrogen binds to specific receptors inside many kinds of cells, each of which have different |
| 49) In research on aging (both cellular aging and organismal aging), it has been found that aged cells do not progress through the cell cycle as they had previously. Which of the following would provide evidence that this is related to cell signaling? | Growth factor ligands do not bind as efficiently to receptors. |
| 50) Where do apoptotic signals come from? | all of the above: the nucleus,the ER, ligand binding, mitochondrial protein leakage |