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Question | Answer |
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The client states, “I always keep my lisinopril (Prinivil) on my kitchen window sill. It helps me to remember to take it.” The nurse’s response would be based on what pharmacologic concepts? Heat and moisture may: | Cause the medicine to break down. |
A client is hospitalized for uncontrolled hypertension and is receiving angiotensin converting enzyme (ACE) inhibitors. The nurse should notify the health care provider if the client exhibits: | Nonproductive cough. |
The nurse is caring for a client with chronic hypertension. The client is receiving losartan (Cozaar) daily. Which client manifestations would the nurse conclude is an adverse effect of this medication? | Headache and dizziness |
Losartan (Cozaar) is prescribed for a client. A nurse should question the order for what client? A client who has: | Severe dehydration from diuretic therapy. |
A client is receiving lisinopril (Prinivil) for hypertension. The nurse should ask the client about a history of what condition? | Angioedema |
The nurse has just administered a dose of an angiotensin II receptor blocker to a client. After the initial dose, what is the priority assessment? | Blood pressure |
A client who is taking losartan (Cozaar) asks a nurse how the medication works. The nurse’s response should be based on an understanding that losartan (Cozaar): | is an ARB which blocks antiotensin II after it is formed. |
The nurse is talking with a group of clients with cardiac conditions who are taking diuretic therapy. The nurse explains that individuals prescribed furosemide (Lasix) should: | Rise slowly from sitting or lying positions. |
The client who is receiving a high-ceiling diuretic is instructed to watch for symptoms associated with electrolyte imbalances. Which condition would the client most likely expect? | Hypokalemia |
While preparing a client for discharge, what statement should the nurse include in the instructions regarding the client’s new prescription of furosemide (Lasix)? | “Report muscle cramps or weakness to the health care provider.” |
Clients prescribed spironolactone (Aldactone) are often at risk for electrolyte imbalance. The nurse assesses for this adverse effect because this drug: | Retains potassium. |
What nursing measures should be included in the therapeutic management of a client receiving spironolactone (Aldactone)? | Keep the urinal or bedpan available for clients with limited mobility. Monitor intake and output ratio, and weigh the client daily. Monitor blood pressure and assess for orthostatic hypotension. |
The nurse is monitoring a client receiving acetazolamide (Diamox).Which acid–base imbalance is a potential risk for this client? | Metabolic acidosis |
When should furosemide (Lasix)be administered to a client with stable hypertension? | Schedule doses to avoid sleep disturbance and nocturia |
A client who is taking furosemide (Lasix) for the treatment of congestive heart failure asks a nurse how the medication works. The nurse's response should be based on an understanding that Lasix: | Inhibits the reabsorption of sodium. |
The nurse knows that teaching a client about hydrochlorothiazide (HCTZ) has been successful when the client voices what statement regarding weight gain? | “I should report weight gain of 2 or more pounds within 2 days.” |
mannitol (Osmitrol) is contraindicated for patients with what problems? | Dementia, Dehydration, Hypovolemic shock |
Methyldopa (Aldomet) is being initiated for a client with hypertension. What health teaching would be most appropriate for this drug? | Avoid hot baths and showers, and prolonged standing in one position. |
A client is receiving a direct vasodilator for elevated blood pressure levels. The nurse would include in the care plan to monitor the client for what adverse effect? | Orthostatic hypotension |
The nurse determines that the client understands an important principle in self-administration of hydralazine (Apresoline) when the client makes what statement regarding driving? | “I should not drive until the response to drug therapy is determined.” |
A client with hypertensive crisis is started on nitroprusside (Nipride) therapy. The nurse would perform what priority intervention during the course of this treatment? | Titrate intravenous infusion rate according to the blood pressure response. |
The nurse knows that the primary factors responsible for blood pressure are: | Cardiac output. Peripheral resistance. Blood volume. |
The client, who is receiving a daily dose of methyldopa (Aldomet), informs the nurse that the medication is causing severe drowsiness during the day. What would be best when addressing this complaint? | “You can minimize daytime sedation by changing medication dosages to nighttime.” |
The client taking hydralazine (Apresoline) is experiencing agranulocytosis. The nurse would assess the client for what? | Sore throat, fever, and signs of infection |
The client has developed hypotension, lethargy, blurred vision, and metabolic acidosis following 4 days of nitroprusside (Nipride) administration. The nurse suspects the client may be developing: | Thiocyanate poisoning. |
Hydralazine (Apresoline) is prescribed for a client. A nurse would question the order for which client? | The client with lupus. The client with cerebrovascular disease. The client with coronary artery disease. The client with rheumatic heart disease |
The nurse will administer Nitroprusside sodium (Nipride) to the client with a diastolic pressure of greater than 120 mm Hg. The nurse will administer this medication by what route? | Intravenous |
What laboratory findings would cause the nurse to be concerned about digoxin (Lanoxin) toxicity? | Hypokalemia |
In providing the heart failure client with information prior to discharge, the nurse will discuss digoxin (Lanoxin) therapy.What would the nurse include in the client‘s teaching? | Monitor the pulse daily prior to taking the drug. |
The nurse is evaluating the effects of a drug that causes a positive inotropic effect. The nurse knows that an agent with this property: | Increases the force of cardiac contractions. |
The client is receiving milrinone (Primacor) infusion for heart failure. The nurse should monitor this client for: | Heart beat irregularities |
The nurse is explaining the reason that angiotensinconverting enzyme (ACE) inhibitors are prescribed for heart failure to a group of clients in a cardiac rehabilitation session. The nurse’s response is based on knowing that ACE inhibitors: | Slow the progression of heart failure and reduce mortality |
The nurse is caring for several clients with heart failure. What would the nurse consider appropriate pharmacologic therapy for a client with heart failure? | Angiotensin-converting enzyme (ACE) inhibitors, Diuretics, Cardiac glycosides Phosphodiesterase III inhibitors |
What statement made by a client indicates that additional teaching by the nurse concerning digoxin (Lanoxin) is needed in regards to pedal edema? | "Swelling in my ankles or feet is not uncommon with this medicine.” |
Normal regulaton of BP: | vasomotor factors, baroreceptors, chemoreceptors, emtions, hormones and other agents |
Where is the vasomotor center located? | Medulla oblongata |
what happens when smoot muscle in arteries contracts? | BP raises |
What happens when smooth muscle in arteries relaxes? | BP lowers |
Where are baroreceptors located? | In the aorta and internal carotid arteries. |
Where are chemoreceptors located? | In aorta and internal carotid areteries. |
How can anger and stress affect BP? | raise it |
How can mental depression and lethargy affect BP? | lower it |
Which hormones can increase BP? | epinepherine/norepinephrine, antidiuretic hormone, renin-angiotensin system |
Which of the following is not a factor in BP? venous pressure, arterial resistance, cardiac output, blood volume | venous pressure |
What is stepped care regarding HTN meds? | use two drugs from different classes |
advantage to stepped care | lower dose of each drug, fewer side effects leading to better client compliance |
five primary classes of drugs to treat chronic HTN | diuretics, calcium channel blockers, ACE inhibitors, adrenergic agents, direct-acting vasodilators |
which drug reduces blood volume through urinary excretion of water and electrolytes | diuretics |
biggest electrolyte imbalance with diuretics | hypokalemia |
nursing considerations for patients on diuretics include: | monitor for dehydration and hypovolemia, monitor labe values (esp sodium and potassium), daily weights, intake and output |
three classes of diuretics | potassium sparing, thiazide, loop |
potassium sparing diuretics are contraindicated for which patients | renal insufficiency, hyperkalemia, pregnancy, hx of gout or kidney stones |
Class of triamterene (Dyrenium) | potassium sparing diuretic |
class of amiloride (Midamor) | potassium sparing diuretic |
spironolactone (Aldactone) | potassium sparing diuretic |
bigges side effect of spironolactone (Aldactone) | Men: gnecomastia and androgenic effects; Women: hirsutism |
Thiazide and thiazide-like diuretics-monitor lab values for: | hypokalemia, uric acid level (Gout), serum lipid levels (may increase) |
Thiazide considerations with hyperglycemia: | dec effectiveness of anti-diabetic meds |
thiazide considerations with lupus | exacerbate |
IV push of loop/high ceiling diuretics need to be anministered: | slowly by IV push or will cause ototoxic |
hydrochlorothiazide (HCTZ, Hydrodiuril) class | loop diuretic |
side effects/adverse effects of hydrochlorothiazide (HCTZ) | hypokalemia (leading to heart irregularities) |
Assessment of patients who are on diuretics should include: | health hx, baseline vs & labs, assess breath sounds and legs for edema |
interventions for the patient on diuretics: | monitor lab values, monitor vs, monitor fluid status, observe for hyperglycemia, monitor hearing, vision, liver and kidney function, nutrition, ensure safety (ambulation and photosensitivity) |
When assessing labe tests, the nurse should know that hypokalemia is a common SE of | diuretics |
What do calcium channel blockers treat? | HTN, angina pectoris, cardiac arrhythmias |
how do calcium channel blockers work? | prevent calcium ions from entering muscle cells causing muslce to not contract as efficiently (also relax arterioles, lower peripheral resistance) |
what class is amiodipine (Norvac) | calcium channel blocker |
what class is nifedipine (Procaria) | carlcium channel blocker |
what class is diltiazem (Cardizem) | calcium channel blocker |
what class is verapamil (Calan) | calcium channel blocker |
intervention unique to CCB | monitor for signs of heart failure |
almost everyone on CCB will have some: | pedal edema |
Actions of nifedipine (Procardia) | blocks Ca channels in heart and smooth muscle |
adverse effects and interactions of nifedipine (Procardia) | HA, dizziness, flushing, inc dig level (warfarin, raitidine), alcohol can cause syncope, grapefruit can cause toxic overdose |
class of lisinopril (Prinvil) | ACE inhibitor |
class of captopril (Capoten) | ACE inhibitor |
class of quinapril (Accupril) | ACE inhibitor |
what does agiotensin converting enzyme (ACE inhibitors) treat | HTN, CHF, MI |
ACE inhibitors block enzyme that change: | angiotensin I to angiotensin II |
Who are ACE inhibitors less effective for? | African Americans |
side effects of ACE inhibitors: | persistent dry cough, postural hypotension, angioedema |
contraindications of ACE inhibitors: | hypersensitivity, hx of angioedema, potassium-sparing diuretic, pregnancy and lactation, renal insufficiency |
when should ACE inhibitors be taken | at bedtime (may cause first dose effect) |
class of elalapril (Vasotec) | ACE inhibitor |
enalapril (Vasotec) adverse effects and interactions: | orthostatic hypotension, angioedema, agranulocytosis, inc risk of lithium toxicity, NSAIDS decrease effectiveness of ACE |
class of irbesartan (Avapro) | angiotensin receptor blocker (ARB) |
class of losartan (Cozaar) | angiotensin receptor blocker (ARB) |
monitor patient on ACE inhibitor for: | blood dyscrasia (bruising, fever, sore throat, dyspnea, pallor), dry cough, fluid balance |
how do antiotensin receptor blockers (ARB) work | block angiotensis II after it is formed, arteriolar dilation, increased sodium excretion |
how do adrenergic blocking agents work for HTN | block effects of sympathetic division of ANS |
What can Alpha-1 antagonists treat? | HTN, benign prostatic hypertrophy (BPH) |
exampes of adrenergic blockers: | beta blockers, Alpha 1 |
class of prazosin (Minipress) | Alpha 1 |
class of terazosin (Hytrin) | Alpha 1 |
side effects of adrenergic blocking agents | orthostatic hypotension, nausea, dizziness, bradycardia, dry mouth, dec libido, erectile dysfunction, depression, asthma exacerbation |
class of doxazosin (Cardura) | Alpha 1 |
how does doxazosin (Cardura) work | dilates arteries and veins |
adverse effects and interations of doxazosin (Cardura) | causes rapid drop in BP, cimetidine (Tagamet) prolongs half life |
how do beta blockers work | adrenergic antagonists, dec contractility and rate, dec O2 demand, hypoglycemia without symptoms |
what do cardioselective (beta 1) blockers do | decrease HR and myocardial contractility, non-specifice additionally affect respiratory system and blood vessels (vasocontriction), dec myocardial contractility and heart rate |
Which drugs are often used in hypertensive emergencies? | direct vasodilators |
It is important to monitor what when a patient is on direct vasodilators for emergency? | continuous BP measurement (may need arterial line) |
contraindications for direct vasodilators | hypersensitivity, CAD, mitral valve disease, cerebrovascular disease, renal insufficiency, SLE (lupus), priapism |
class of diazoxide (Hyperstat) | direct vasodilator (IVP) |
class of nitroprusside (Nipride) | direct vasodilator (IV gtt) |
half life of nitroprusside (Nipride) | 2 minutes |
class of clonidine (Catapres) | direct vasodilator (patch, PO) (also used epidural for cancer pain) |
class of hydralazine (Apresoline) | direct vasodilator |
routes of hydralazine (Apresoline) | PO and parenteral |
adverse effects and interactions of hydralazine (Apresloline) | reflex tachycardia, fluid retention, MAOI and NSAID, abrupt withdrawal may cause rebound HTN |
Which drug is an ACE inhibitor? clonidine (Catapres), losartan (Cozaar), metolrolol (Toprol), captopril (Capoten) | captopril (Capoten) |
signs of heart failure | SHOB, swelling of feet and ankles, chronic lack of energy, difficulty sleeping at night due to breathing problems, swollen or tender abd w/loss of appetite, cough with pink froth sputum, increased urination at night, confusion and/or impaired memory |
goals of treatment for heart failure | prevent, treat, or remove umderlying causes |
disorders associated with heart failure: | mitral stenosis, MI, chronic HTN, CAD, DM |
Heart cannot eject all the blood it receives. Ventricles: | hypertrophy to compensate |
Heart cannot eject all the blood it receives. left ventricle blood: | backs up into lungs |
Heart cannot eject all the blood it receives. right ventricle blood: | backs up into peripheral veins |
traditional drugs of choice for heart failure | cardiac glycosides (digitalis) |
toxic level of digitalis | >1.8 ng/ml |
prior to starting digitalis what test should be performed? | EKG--evaluate any ventricualr dyshrythmias not caused by heart failure |
digitalis side effects | anorexia, nausea, vomitting, fatigue, drowsiness, dizziness, HA, dysrhythmias, visual disturbances (blurred, yellow, halos) |
Oral tabs and liquid digitalis | are not directly interchangeable |
patients on digitalis should report: | visual changes, palpitations, weakness, loss of appetite, nausea, vomitting, diarrhea |
What foods should patients on digitalis consume? | Foods high in potassium (bananas, apricots, sweet potatoes, orange juice) |
digitalis antidote | digoxin immune Fab (Digibind) |
actions of digoxin (Lanoxin) | dec CHF and inc exercise tolerance, suppresses SA node, slows down AV node |
What should be monitored when on digoxin (Lanoxin) | serum levels |
diuretics can lead to hypokalemia; hypokalemia plus dig can lead to: | dysrhythmias |
ACE inhibitors as tx for heart failure: | lower peripheral resistance which decreases afterload and increases cardiac output; dilates veins returning blood to heart which decreases preload and increases peripheral edema |
lisipopril (Prinvil, Zestril) side effects and interactions | cough, nausea, vomitting, headache, diarrhea, taste disturbance, NSAIDs, lithium, potassium sparing diuretics |
vasodilators for heart failure directly relax: | blood vessels which decreases BP (many side effects, reserved for clients who cannot tolerate ACE inhibitors |
isosorbide dinitrate (Isordil) actions and uses | acts of veins to decrease preload, dilates coronary arteries which decreases angina |
SE and AE of isosorbide dinitrate (Isordil) | HA, hypotension, relfex tachycardia |
interactions isosorbide dinitrate (Isordil) | sildenafil (Viagra), alcohol, antihypertensives |
How do diuretics for heart failure work? | reduce blood volume, edema and congestion: workload on heart reduced and cardiac output increased; used in combination with other drugs to treat heart failure |
contraindictaions of diuretics for heart failure | renal dysfunctions, fluid and electrolyte depletion, heptic coma, prenancy and lactation, caution with hepatic cirrhosis or nephrotic syndrome |
nursing considerations for diuretics for heart failure include monitoring: | potassium levels, lab values, intake and output, hypovolemia and dehydration, sodium levels |
patient education diuretics for heart failure max sodium intake: | no more than 4 grams |
patient education diuretics for heart failure report weight loss of more than: | 2 pounds per week |
patient education diuretics for heart failure sign of hypokalemia: | fatigue, muscle cramping |
furosemide (Lasix)blocks: | reabsorption of NaCl and water |
administrations alert for furosemide (Lasix) | Ototoxicity esp when given IVP |
adverse effects furosemide (Lasix) | hypokalemia, poss cross allergy with sulfa drugs |
It is critical for the nurse to evaluate electrolyte levels during digoxin therapy. Which of the following will significantly impact the effect of digoxin? hypokalemia, hypercalcemia, hyperkalemia, hypernatremia | hypokalemia |
phosphodiesterase inhibitors are used for | short term control of acute heart failure |
How long are patient's on phosphodiesterase inhibitors? | generally two to three days |
Phosphodiesterase inhibitors are reserved for clients not responding to: | ACE inhibitors or cardiac glycosides |
class of Inocor | phosphodiesterase inhibitor |
class of Primacor | phosphodiesterase inhibitor |
How do beta-adrenergic blockers for heart failure work? | reduce cardiac workload by decreasing afterload; usually used in combination with other drugs |
contraindications for beta blockers: | monitor for worsening symptoms of heart failure, monitor for hepatic toxicity (LFT's) |
Patient education for beta blockers | monitor BP and pulse, notify HCP if pulse less than 50; do not abruptly stop meds; monitor blood glucose (will have hypoglycemia with no symptoms) |
class of carvedilol (Coreg) | beta blocker |
By what mechanism do diuretics, such as Lasix, improve the symptoms of patients with CHF? blocking beta-adrenergic receptors, causing the heart to beat stronger, reducing fluid/plasma volume, slowing the heart rate, dilating the coronary arteries | reducing fluid/plasma volume |
signs and symptoms of shock: | skin pale, cold, and clammy; behavioral changes ie. restlessness |
assessing for shock: | low blood pressure, rapid weak pulse, rapid and shallow breathing |
types of shock: | hypovolemic, neurogenic, cardiogenic, septic, anaphylactic |
treatment priorities for shock: | open airway, fluid replacement agents, crystalloids (dextrose) and colloids (proteins) |
blood product colloids include: | albumin, plasma protein fraction, serum globulins |
non-blood product colloids: | Dextran, Hetastarch |
What do you assess for circulatory overload? | BP, pulse, lung sounds, I |
Early stages of shock increase activity of what system? | sympathetic nervous system |
Sympathomimetics or beta-adrenergic agonists do what for clients in shock? | stabalize BP |
class of norepinephrine (Levartenol, Levophed) | sympathomimetrics or beta-adrenergic agonists |
class of isoproterenol (Isuprel) | sympathomimetrics or beta-adrenergic agonists |
class of methoxamine (Vasoxyl) | sympathomimetrics or beta-adrenergic agonists |
class of phenylephrine (Neo-Synephrine) | sympathomimetrics or beta-adrenergic agonists |
class of mephentermine (Wayamine) | sympathomimetrics or beta-adrenergic agonists |
prior to administering norepinephrine in patient's with existing CV disease, what considerations are there? | assess EKG rhythm, be aware of specific side effects according to drug being administered, monitor for chest pain and EKG changes |
Prior to administering norepinephrine, assess for history of what disease? | narrow-angle glaucoma (could close the angle and cause blindness) |
norepinephrine adverse effects: | HTN, dysrhytmias (usually tachycardia) |
actions of norepinephrine: | constricts blood vessels (increases BP), strengthens force of contraction (inotropic) |
contraindications norepinephrine: | ventricualr tachycardia, hypertrophic idiopathic subaortic stenosis, pregnancy and lactation, catuion in patients with HTN, hypovolemia |
nursing intervention for extravasation of norepinephrine | administer antidote |
Patients should report what immediately when on norepinephrine? | chest pain, burning or pain at the IV site, paresthesias in extremities |
Most of the agents used to raise BP in patients with shock: are CNS stimulants, are CNS depressants, activate the parasympathetic nervous system, activate the sympathetic nervous system | activate the sympathetic nervous system |
It is important to monitor renal function hourly per foley catheter with norepinephrine for what reason? | for vasoconstriction of renal arteries |
class of dopamine (Dopastat, Intropin) | beta I adrenergic agonist |
How is dopamine administered? | IV gtt, nurse titrates med according to BP every 15 min |
action of dopamine: | low dose: increase blood flow to kidneys; high dose: heart beats stronger and vasoconstriction |