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``` KAT PHR 52
Antiprotazoals
Question | Answer |
---|---|
Which plasmodia have dormant hepatic stages (2) | vivax and ovale |
Which plasmodia have only 1 stage of liver replication (2) | falciparum and malariae |
Primary tissue schizonticide function and example | kill in liver, primaquine |
Primary blood schizonticide function and example | kill in blood, chloroquine, quinine |
Sporonticide example and functions | prevent replication in mosquito, proguanil and pyrimethamine |
Chloroquine absorption affected by | antacids |
Chloroquine excretion | unchanged in urine |
Chloroquine mechanism of action | accumulates toxic heme in parasite |
Chloroquine toxicity at low and high dose | rash, GI irritation, headaches -> neuropathy, porphyria |
Quinine excretion | metabolized before renal excreta |
Quinine mechanism of action | blocks DNA replication and transcription by binding to it |
Quinine toxicity | cinchonism, G6PD hemolysis, Blackwater fever, contra in pregnancy |
Mefloquine is used for _ and is administered _ | prophylaxis in chloroquine resistant areas, by mouth |
Primaquine metabolism | extensive |
Primaquine toxicity | contra in preg, G6PD hemolysis |
Antifolate drugs (4) | pyrimethamine, proguanil, sulfadoxine, dapsone |
Antifolate drugs mechanism of action | sulfonamides block PABA, proguanil and pyrimethamine block DHFR |
Doxycycline is a _ used for _ | tetracycline for prophylaxis |
Amodiaquine is _ and has _ side effects | anti malarial, hepatic |
Atovaquone mechanism | disrupt mitochondria |
Halofantrine is a _ and has _ side effects | anti malarial, cardiotoxic |
Only drug effective against quinine resistant strains | artemisinin |
First choice for asymptomatic ameba disease | diloxanide |
Emetine is used for _ and mechanism _ | amebic disease, blocks ribosome |
Iodoquinol is used for _ and side effects are _ | amebicide, thyroid and iodine toxicity, neurotoxicity |
Metronidazole and tinidazole are used for | amebic disease and for H pylori |
Metro/Tini mechanism | form cytotoxic products with nitro group |
Metronidazole and tinidazole toxicity | irritation, urine coloration |
Paromomycin is a | aminoglycoside |
Nitazoxanide is used for | GI infections from G lamblia and cryptosporidium |
Pentamidine is used for | pneumocystosis and toxoplasmosis |
Pentamidine mechanism | inhibit glycolysis, interfere with nucleic metabolism |
TMP SMZ is used for | 1st choice in pneumocystis |
TMP SMZ side effects | GI distress, neutropenia, thrombocytopenia |
Pyrimethamine and sulfonamides are effective against | toxoplasmosis |
Pyrimethamine and sulfonamide mechanism | block folic acid synthesis |
Atovaquone mechanism | blocks mitochondria and folate |
Atovaquone is for | mild pneumocystis |
Pentamidine is for | T gambiense and rhodesiense |
Melarsoprol is for | sleeping sickness |
Melarsoprol mechanism | inhibits sulfahydryls, is arsenic |
Nifurtimox is for | trypanosomiasis |
Nifurtimox mechanism | inhibits trypanothione reductase |
Suramin is for | early trypanomiaisis |
Eflornithine is a | ornithine decarboxylase substrate |
Eflornithine is used for | some trypanosomiaisis |
Stibogluconate is for | Leishmania |
Stibogluconate side effects | cardiotoxic |