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``` KAT PHR 52

Antiprotazoals

QuestionAnswer
Which plasmodia have dormant hepatic stages (2) vivax and ovale
Which plasmodia have only 1 stage of liver replication (2) falciparum and malariae
Primary tissue schizonticide function and example kill in liver, primaquine
Primary blood schizonticide function and example kill in blood, chloroquine, quinine
Sporonticide example and functions prevent replication in mosquito, proguanil and pyrimethamine
Chloroquine absorption affected by antacids
Chloroquine excretion unchanged in urine
Chloroquine mechanism of action accumulates toxic heme in parasite
Chloroquine toxicity at low and high dose rash, GI irritation, headaches -> neuropathy, porphyria
Quinine excretion metabolized before renal excreta
Quinine mechanism of action blocks DNA replication and transcription by binding to it
Quinine toxicity cinchonism, G6PD hemolysis, Blackwater fever, contra in pregnancy
Mefloquine is used for _ and is administered _ prophylaxis in chloroquine resistant areas, by mouth
Primaquine metabolism extensive
Primaquine toxicity contra in preg, G6PD hemolysis
Antifolate drugs (4) pyrimethamine, proguanil, sulfadoxine, dapsone
Antifolate drugs mechanism of action sulfonamides block PABA, proguanil and pyrimethamine block DHFR
Doxycycline is a _ used for _ tetracycline for prophylaxis
Amodiaquine is _ and has _ side effects anti malarial, hepatic
Atovaquone mechanism disrupt mitochondria
Halofantrine is a _ and has _ side effects anti malarial, cardiotoxic
Only drug effective against quinine resistant strains artemisinin
First choice for asymptomatic ameba disease diloxanide
Emetine is used for _ and mechanism _ amebic disease, blocks ribosome
Iodoquinol is used for _ and side effects are _ amebicide, thyroid and iodine toxicity, neurotoxicity
Metronidazole and tinidazole are used for amebic disease and for H pylori
Metro/Tini mechanism form cytotoxic products with nitro group
Metronidazole and tinidazole toxicity irritation, urine coloration
Paromomycin is a aminoglycoside
Nitazoxanide is used for GI infections from G lamblia and cryptosporidium
Pentamidine is used for pneumocystosis and toxoplasmosis
Pentamidine mechanism inhibit glycolysis, interfere with nucleic metabolism
TMP SMZ is used for 1st choice in pneumocystis
TMP SMZ side effects GI distress, neutropenia, thrombocytopenia
Pyrimethamine and sulfonamides are effective against toxoplasmosis
Pyrimethamine and sulfonamide mechanism block folic acid synthesis
Atovaquone mechanism blocks mitochondria and folate
Atovaquone is for mild pneumocystis
Pentamidine is for T gambiense and rhodesiense
Melarsoprol is for sleeping sickness
Melarsoprol mechanism inhibits sulfahydryls, is arsenic
Nifurtimox is for trypanosomiasis
Nifurtimox mechanism inhibits trypanothione reductase
Suramin is for early trypanomiaisis
Eflornithine is a ornithine decarboxylase substrate
Eflornithine is used for some trypanosomiaisis
Stibogluconate is for Leishmania
Stibogluconate side effects cardiotoxic
Created by: asindhidude