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KAT PHR 59

Gastrointestinal Drugs

QuestionAnswer
Proton pump inhibitors, prototype omeprazole
Proton pump inhibitors, mechanism of action irreversible blockade of H/K ATPase
Proton pump inhibitors, side effects can affect absorption of other drugs in stomach
H2 receptor blocker, prototype cimetidine
H2 receptor blocker, mechanism of action block histamine
H2 receptor blocker, side effects (2) antiandrogenic, CYP inhibitor (cimetidine only)
Prokinetic agents, prototype metoclopramide
Prokinetic agent, mechanism of action D2 block, increase stomach emptying and intestinal motility
Prokinetic agent, side effect (1) parkinsonism
Drug used for prokinetic effects, non prototype (2) macrolides and cholinomimetics (neostigmine)
Drug used for IBS alosetron
Alosetron mechanism of action 5HT3 antagonist, reduces smooth muscle activity
Alosetron side effects constipation, colitis, bowel infarction
Lubiprostone is a _ and used for _ chloride channel activator, IBS in women
Antiemetics, prototype ondansetron
Ondansetron, mechanism of action 5HT3 block in GI, CNS (antagonist)
Drug used for anti emetic effects in chemotherapy, mechanism, side effect aprepitant, neurokinin 1 antagonist, CYP interaction
Antidiarrheal drug, prototype loperamide
Antidiarrheal drug, mechanism of action activate u receptor, slows motility
Antidiarrheal drug, OTC variant kaolin, a magnesium aluminum silicate + pectin
IBD drug prototype mesaclamine (5 ASA)
IBD drug, mechanism of action unknown, inhibit inflammatory cytokines
IBD drugs, adverse affects due to sulfapyradine
Drug used to prevent gallstones and mechanism ursodiol, decrease CH secretion
Sucralfate is used for _, and works by _ ulcers, forms a coating over injury
Misoprostol is used for _ and works by _ NSAID induced ulcers, inhibits acid secretion as PGE1 analog
Colloidal bismuth is used for _ and side effect mucosal protection, black stool
Created by: asindhidude