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Vitamins UAG

Vitamins deficiency

What is the active form of thiamine B1? Thiamine Pyrophosphate (TPP)
List two conditions caused by a thiamine B1 deficiency Beriberi and Wernicke-Korsakoff
Where is beriberi often found and why? Asia because the thiamine rich grain husks are stripped off by the rice polishing process.
Thiamine is a cofactor of enzymes catalyzing which reactions? pyruvate to acetyl CoA alpha ketoglutarate to succinyl CoA Ribose 5-P Xylulose 5-p to sedoheptulose 7-p + glyceraldehyde 3-p
TTP is a cofactor for which enzymes Pyruvate dehydrogenase(glycolysis) Transketolase (HMP shunt) Alpha-ketoglutarate dehydrogenase (TCA) Branched chain AA dehydrogenase
Which lab finding indicates a thiamine deficiency? Increase in erythrocyte transketolase activity upon addition of TPP
What causes Wernicke-Korsakoff syndrome in the US? Chronic alcoholism causing dietary insufficiency or impaired intestinal absorption of Thiamine
List some nonalcoholic conditions associated with Wernicke's Encephalopathy? Prolonged IV feeding, IV hyperalimentation, Hyperemesis gravidarum, Arexia nervosa, Prolonged fasting, Refeeding after starvation, Gastric plication
Signs and symptoms of Wernicke-Korsakoff mystagmus, ataxia, memory disordrs, disorientation (chronic alcoholics)
Signs and symptoms of beriberi Wet-cardiovascular (high-output cardiac failure, edema) Dry-CNS manifestations (polyneuritis)
What are the active forms of Riboflavin B2? Flavin mononucleotide (FMN) Flavin adenine dinucleotide (FAD)
Signs and symptoms of riboflavin deficiency 2Cs-Corneal vascularisatin and Cheilosis (inflammation of lips, scaling and fissures at the corner of the mouth)
Which process is affected by riboflavin deficiency? Electron transport system, Oxydation and reduction of substrates.
What is the earliest sign of riboflavin deficiency? Proliferation of the bulbar conjunctival capillaries
What are the
Created by: sorykaba



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