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PT 201 Ch 10 review

QuestionAnswer
Absorption The movement of the drug from the dosage formulation in the blood.
Active transport The movement of the drugs from an area of lower concentration to an area of higher concentration; requires cellular energy.
Agonist Drugs that activate receptors to accelerate or slow normal cellular function.
Antagonists Drugs that bind with receptors but do not activate them.
Bioavailability The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs.
Bioequivalency The comparison of bioavailability between two dosage forms.
Biopharmaceutics The study of the factors associated with products and physiological processes, and the resulting systemic concentrations of drugs.
Complexation When different molecules associate or attach to each other.
Disposition A term sometimes used to refer to all the ADME processes together.
Duration of action The time the drug concentration is above the MEC.
Elimination The process of metabolism and excretion.
Enterohepatic cycling The transfer of drugs and their metabolites from the liver to the bile in the gall bladder, then into the intestine, and then back into circulation.
Enzyne A complex protein that catalyzes chemical reactions.
Enzyme induction The increase in hepatic enzyme activity that results in greater metabolism of drugs.
Enzyme inhibition The decrease in hepatic enzyme activity that results in reduced metabolism of drugs.
First pass metabolism The substantial degradation of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systemic circulation.
Gastric emptying time The time a drug will stay in the stomach before it is emptied into the small intestine.
Glomerular filtration The blood filtering process of the nephron.
Hydrophilic Capable of associating with or absorbing water.
Hydrophobic Water repelling;cannot associate with water
Lipoidal Fat-like substance.
Metabolite The substance resulting from the body's transformation of an administered drug.
MEC-minimum effective concentration The blood concentration needed for a drug toproduce a response.
MTC-minimum toxic concentration The upper limit of the therapeutic window.
Nepron The functional unit of the kidney
Onset of action The time MEC(minimum effective concentration) is reached and the response occures
Passive diffusion The movement of drugs from an area of higher concentration to lower conentration.
Pharmaceutical alternative Drug products that contain the same active ingredient but not necessarily in the same salt form, amount, or dosage form.
Pharmaceutical equivalent Drug products that contain identical amounts of the same active ingredient in the same dosage form.
Protein binding The attachment of a drug molecule to a protein, effectively making the drug inactive.
Receptor The cellular material which interacts with the drug.
Selective (action) The characteristic of a drug that makes its action specific tocertain receptors.
Site of action The location where an administered drug produces an effect.
Theraputic equivalent Pharmaceutical equivalents that produce the same effects in patients.
Therapeutic window A drug's blood concentratin range between its MEC (min effective concentration) MTC (min toxic concentration).
Created by: blessed2giv
 

 



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