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Cancer Jeopardy
| Question | Answer |
|---|---|
| Act as genetic lock when cell becomes differentiated | Proto-oncogenes |
| Cell that looks nothing like the cell from which it arose | Anaplastic cell |
| Sequence of genetic mutations that are believed to activate proto-oncogenes and inactivate tumor suppressor genes | Initiation |
| Cells have lost tissue identity, have reverted to primitive state, but remain localized and have not invaded tissues below surface | Carcinoma in situ |
| Internationally recognized staging system | TNM |
| Proteins that can be produced by the body in response to cancer growth or by cancer cells themselves | Tumor markers |
| Normal cells stop reproducing when they touch one another. Cancer cells lose this property | Contact inhibition |
| There are changes in growth factors that allow cancer cells to keep multiplying. They may even secrete their own growth factors. This is called | Autocrine stimulation |
| A region of DNA at the end of a chromosome; cancer cells can maintain these and be immortal | Telomeres |
| The ability of a malignant tumor to develop its own blood supply | Angiogenesis |
| This hormone has been linked with both breast and uterine cancer | Estrogen |
| Known cause of cancer, leading cause of cancer, leading preventable cause of death | Smoking |
| Type of radiation associated with malignant melanoma | UV radiation |
| Foreign bodies and oncogenic viruses are considered which type of carcinogen | Physical |
| The long latency period from exposure to development of cancer makes it difficult to identify these types of carcinogens | Chemical |
| Cancer that would arise from hematopoietic (blood forming) cells | Leukemia |
| When a tumor is graded histologically a 4 step system is used. Grade III would indicate | Severe dysplasia and poorly differentiated |
| In the TNM staging system, M stands for | Metastasis |
| Colon cancer can spread to the liver via venous drainage from the gut. This is which type of metastasis? | Blood borne |
| One example of a benign tumor causing harm is this type of brain tumor | Astrocytoma |
| Type of tumor that is most responsive to radiation | Rapidly dividing |
| Most distressful side effect of radiation therapy | Fatigue |
| This type of cancer therapy stimulates the immune system to work harder or smarter | Biotherapy |
| All but one of the following is a category of anticancer drug | Synthroid |
| Cytoxan is an example of this class of cytotoxic agents; it breaks the DNA helix in cancer cells | Alkylating agent |
| Major manifestation of cancer; characterized by extremely wasted appearance | Cachexia |
| Process by which a cell acquires new characteristics | Differentiation |
| The most common route for metastasis is through the | Lymphatics |
| A patient is receiving methotrexate and has severe bone marrow depression. Which intervention will decrease this problem? | Leucovorin rescue |
| A patient is receiving a combination of drugs to treat metastatic breast cancer. What is the rationale for combination therapy? | Increased cancer cell kill |
Created by:
heathrow