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Pharm Chapter 5
| Question | Answer |
|---|---|
| The perception of pain is the patient’s emotional or psychologic response to pain and varies greatly from individual to individual. | FALSE |
| The reaction to pain is the physical component to the message of pain as it is carried through the nervous system and is the same for everyone. | FALSE |
| The site of action on nonopioid analgesics is: | At the peripheral nerve endings |
| The primary action of the nonopioid analgesics is depression of the central nervous system. The inhibition of prostaglandin synthesis reduces the perception of pain. | D) The first statement is false; the second statement is true. The primary action of nonopioid analgesics is to inhibit prostaglandin synthesis at the peripheral nerve endings. |
| All of the following are classifications of nonopioid analgesics except one. Which one is the exception? | **A) Narcotics B) Salicylates C) Acetaminophen D) Nonsteroidal antiinflammatory drugs (NSAIDs) |
| Which of the following best describes the mechanism of action for the salicylates? | Uricosuric, antipyretic, antiinflammatory, antiplatelet |
| All of the following are adverse drug effects of aspirin except one. Which one is the exception? | A) Gastrointestinal upset and bleeding B) Increased bleeding time C) Reye’s syndrome ** D) Constipation E) Problems during pregnancy and delivery |
| The most common adverse reaction to aspirin is: | Gastrointestinal upset |
| Dangerous bleeding can occur when which of the following drugs is combined with warfarin? | A) Aspirin |
| The drug of choice for inflammatory dental pain is: | Ibuprofen |
| NSAIDs and aspirin reduce inflammation by inhibiting the synthesis of: | Prostaglandins |
| Acetaminophen has all of the following pharmacologic actions except one. Which one is the exception? | A) Analgesia B) Antipyretic ** C) Antiinflammatory D) Hepatoxic |
| The drug of choice for fever reduction in children is: | Acetaminophen |
| Which of the following analgesics would be best for a patient with asthma for relief of a headache or other mild to moderate pain? | Acetaminophen |
| Which of the following nonopioid analgesics is recommended for prevention of coronary artery disease and treatment of myocardial infarction? | Aspirin |
| Which of the following statements is true regarding the effects of combining caffeine and aspirin? | Caffeine potentiates the analgesic properties of aspirin. |
| All of the following statements are true about pain except one. Which one is the exception? | A decrease in the pain threshold or greater reaction to pain has been said to be associated with emotional stability. |
| Nonopioid drugs can be divided into the following groups as analgesics: | A) Salicylates (aspirin-like group) B) Acetaminophen C) NSAIDs D) Steroidal antiinflammatory drugs E) All of the above **F) a, b, and c only |
| Which of the following groups of analgesics are most closely related? | Salicylates and NSAIDs |
| Aspirin has all of the following effects except one. Which one is the exception? | A) Analgesic B) Antipyretic C) Antiinflammatory **D) Central nervous system depression E) Antiplatelet |
| Aspirin is most effective against what type of pain? | Throbbing or inflammatory |
| Aspirin is absorbed rapidly from the: | Stomach and small intestine |
| An aspirin tablet applied topically to the oral mucosa is an effective way to treat a toothache. | FALSE |
| Aspirin has a long history of use for relief of mild to moderate pain such as a headache or toothache, and aspirin’s worth as an analgesic is well recognized by the lay public. | C) The first part of the statement is true; the second part is false. |
| Fever is regulated in which area of the body? | Hypothalamus |
| Which of the following statements is most correct regarding the use of aspirin as an antipyretic? | *A) Aspirin reduces fever by inducing central vasodilation. *B) Aspirin reduces elevated and normal temp. |
| Aspirin can have adverse drug interactions with which of the following drugs? | A) Probenecid B) Warfarin C) Methotrexate D) Sulfonylureas E) Antihypertensives **F) All of the above G) a, b, and d only |
| Buffered aspirins claim to produce fewer gastrointestinal adverse effects. Numerous clinical studies support this claim. | C) The first statement is true; the second statement is false. |
| This group of analgesics is believed by many authors to be the most useful in treating dental pain. | NSAIDs |
| NSAIDs are similar in their analgesic, antipyretic, and antiinflammatory actions to the salicylates. They differ in their: | Platelet binding, effect on serum uric acid |
| What is the mechanism by which the salicylates and the NSAIDs cause gastrointestinal irritation, pain, and bleeding problems? | Inhibition of the production of cytoprotective mucus in the stomach |
| Which of the following statements is true regarding NSAIDs? | Central nervous system side effects include sedation, dizziness, confusion, mental depression, headache, vertigo, and convulsions, which are dose dependent. |
| How long before the procedure should a patient scheduled for oral surgery avoid ibuprofen? | ) 2 days |
| NSAIDs can dangerously decrease renal blood flow and glomerular filtration in what population? | Patients with renal disease |
| NSAIDs may increase the drug effects and toxicity when given with these medications: | ) Angiotensin-converting enzyme (ACE) inhibitors B) Lithium C) Digoxin D) Cyclosporine E) Methotrexate F) All of the above may have increased drug effects and toxicity **G) b, c, e, and e only |
| NSAIDs are indicated for which of the following conditions? | Osteoarthritis |
| All of the following drugs are NSAIDs except one. Which one is the exception? | ) Phenacetin |
| The primary advantage of the cyclooxygenase II (COX II)-specific inhibitors is: | No real therapeutic advantage over nonselective NSAIDs |
| Acetaminophen has which of the following therapeutic indication? | A) Analgesic B) Antiinflammatory C) Antipyretic D) Antiplatelet E) All of the above **F) a and c only |
| What is the maximal safe dose of alcohol that may be ingested with 2 grams of acetaminophen in a normal adult? | One drink a day |
| The risk of nephrotoxicity increases with what pattern of analgesic usage? | A) Occasional B) Chronic, long term C) Concurrent use of acetaminophen, aspirin, and NSAIDs D) b only **E) b and c only |
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