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Pneumonia.

Chest medicine- test 2

QuestionAnswer
What is pneumonia? pneumonitis with consolidation
What is surface phagocytosis? when polumorphonuclear leukocytes move into the infected area to engulf and kill invading bacteria onthe alveolar walls
What is consolidation? when the alveoli become filled with fluid, RBC's, polymorphonuclear leukocytes and macrophages
What are the 3 major pathologic or structural changes associated with pneumonia? Inflammation of alveoli, Alveolar consolidation, and Atelectasis
What type of percussion sound is heard in a patient with pneumonia? Dull, flat
What type of breath sounds are heard in a patient with pneumonia? bronchial breath sounds
Why do you only auscultate bronchial breath sounds in a pneumonia patient? bronchial breath sounds are prevented from being converted to vesicular bc of consolidation
What is Whispered Pectoiliquy? Whispered sounds are more clearly heard during auscultation when consolidation present
Atelectasis is often associated with what type of pneumonia? aspiration pneumonia
How many people are estimated to die from pneumonia each year? more than 60,000
What is the pathogenesis of pneumonia? causative factor, inflammatory response, Capillary effusion, cellular and bacterial debris, and consolidation
What happens during the inflammatory response of pneumonia? accumulate fluid, narrows airways, stimulate irritant receptors, diminishes lung volume
Capillary effusion involves what 4 things? Serum, RBC, Leukocytes, macrophages
Causes of pneumonia bacteria, viruses, fungi, TB, anaerobic organisms, aspiration, and inhaling irritating chemicals such as chlorine
Wha is Lobar pneumonia? pneumonia involving an entire lobe of the lung
What is double pneumonia? When both lungs are involved
What is the organism most often associated with "walking pneumonia"? Mycoplasma pneumoniae
Why is pneumonia an insidious disease? bc its symptoms vary greatly depending on the patient's specific underlying condition and type of organism causing the pneumonia
There are over ___ causes for pneumonia 30
When does bacterial pneumonia often occur? after an individual has had an upper respiratory infection such as cold or flu
What are early signs and symptoms of bacterial pneumonia? shaking chill, shaking, high fever, sweating, chest pain, increased RR, and cough with yellow and green sputum.
Is bacterial pneumonia most often lobar or double? lobar, its usually confined to just one lobe of the lung
What are the 4 classes of baterial causes Gram +, Gram -, Atypical, and Anaerobic
What are the 2 Gram + organisms that cause bacterial pneumonia? Streptococcus and Staphylococcus
What is Streptococcus pneumoniae? a Gram+, nonmotile coccus that is found singly, in pairs, and in short chains and is the most common pneumonia
Which bacteria accounts for 80% of bacterial pneumonias? Streptococcus pneumoniae
There are more than __ different types of S.pneumoniae 80
What causes the increased virulence of S. pneumoniae? it is enclosed in a polysaccharide capsule
What S.pneumoniae is the most virulent? Serotype 3
How are streptococci usually transferred? by aerosol from a cough or sneeze of an infected individual
Most strains of Streptococcus Pneumoniae are sensistive to what medication? penicillin and its derivatives
S.Pneumoniae is commonly cultured from the sputum of patients having what? an acute exacerbation of chronic bronchitis
What are the 2 major groups of Stapylococcus? Coagulase positive and Coagulase negative
What is Staphylococcus aureus? coagulase positive staphylococcos found in anterior nasal carriage in 20-40% of humans
Which Staphylococcus is responsible for most "staph" infections in humans? S. aureus
Coagulase negative staphylococcus, normal inhabitant of the skin, forms biofilms on plastic medical devices and damaged heart valves(endocarditis) Staphylococcus epidermidis?
Coagulase negative Satphylococcus, found widely in the environment and causes up to 20% of UTI in sexually active women ages 15-35 Staphylococcus saprophyticus
How are staphylococci arranged? in clusters
When does Staphyloccal pneumonia usually occur and in whom? usually follows a predisposing virus infection and is seen most often in children and immunosuppressed adults
How is S. aureus transmitted? by aerosol from a cough or sneeze of an infected individual and indirectly via contact ith contaminated floors, bedding, clothes etc
What are staphylococci a common cause of? hospital acquired pneumonia
What is MDRSA? multiple drug resistant S. aureus
7 Gram (-) Pneumonia causing bacteria haemophilus influenzae, klebsiella, Pseudomona aeruginosa, Moraxella catarrhalis, Escherichia coli, Serratia species, and Enterobacter species
the major Gram (-) organisms responsible for pneumonia are what shape? rod shaped known as bacilli
What is Haemophilus influenzae? a common inhabitant of the human pharyngeal flora, smallest 1.5u-0.3u, gram(-) bacilli that appears as a coccobacilli on gram stain
There are six types of H. influenzae but only type ___ is commonly pathogenic B
Who is pneumonia caused by H. influenzae type B most often seen in? children 1 month- 6yrs old
H. influenza type B is almost always the cause of what? acute epiglottitis
H. influenza can also cause otitis media, meningitis, pneumonia and bacteremia
What is the vaccine for H. influenza? HIB (polysaccharide-protein conjugate vaccine)
How is H. influenzae transmitted? via aerosol or contact with contaminated objects (nasopharyngeal carriage rate 2-5%)
What are some additional risk factors for H. influenzae infection? COPD, defects in B-cell function, functional and anatomic asplenia, and HIV infection
Klebsiella pneumoniae is AKA Friedlander's bacillus
K.pneumoniae have long been associated with what type of pneumonia and who? lobar pneumonia particularly in men over 40 and in chronic alcoholics of both genders
What is Klebsiella? gram(-) bacillus found in chains and a normal inhabitant of the GI tract.
How is K.pneumoniae transmitted? aerosol and contaminated items
K.pneumoniae is a common nosocomial infection with a high mortality rate bc septicemia is a frequent complication
Pseudomona aeruginosa is AKA Bacillus Pyocyaneus
What is P. aeruginosa? highly motile, gram(-) bacillus that colonizes in the GI tract, burns and catheterizes urinary tract and is a contaminant is many aqueous solutions
Risk factor for P. aeruginosa infection neutropenia, HIV, preexisting lung disease, ET tube and prior Antibiotic use
P. aeruginosa is a leading cause of hospital acquired infection and is usually cultured from the respiratory tract of chronicall ill, tracheostomized patients
Why is P. aeruginosa a particular problem from respiratory therapists? bc it thrives in dampness and is usually cultured from contaminated respiratory equipment
How is P.aeruginoa transmitted? aerosol or contact with contaminated items
The sputum from patients with Pseudomonas infection is frequently purulent, green, viscous and sweet smelling
This Gram(-) bacillus is naturally found in the human pharynx and is the 3rd most common cause of acute exacerbation of chronic bronchitis(COPD exacerbation) Moraxella catarrhalis
This Gram(-) bacillus is normall found in the intestinal tract and is sometimes the cause of nosocomial penumonia Escherichia coli
This Gram(-) bacillus causes about 7% of nosocomial pneumonia Serratia species
4 Atypical bacterial causes of pneumonia Mycoplasma pneumoniae, Legionella pneumophila, Chlamydia psittaci, and Chlamydia pneumoniae
People infected with this Atypical bacterial cause of pneumonia are often said to have "walking pneumonia" bc symptoms are mild Mycoplasma pneumoniae
M. pneumoniae lacks a cell wall therefore it is resistant to ______ but sensitive to _________ penicillin resistant, tetracycline sensitive
Why is mycoplasma pneumoniae considered the primaery atypical pneumonia(PAP)? organism escapes ID by standard bacterial tests
What is a common symptom of M. pneumoniae infection? cough that comes in violent attacks producing only a small amount of white mucus
Mycoplasma are smaller than _____ but bigger than ______ bacteria, viruses
M. pneumoniae is often seen in who and when? people younger than 40, during late summer and early fall months., schools, crouds, homeless shelters
What is Legionella pneumophila? an unusual and fastidious gram(-) bacillus with atypical concentrations of certain branched-chain lipids that muliplies in standing water.
How is L.pneumophila transmitted? when it becomes airborne it enters throught the patient's lungs as an aerosol
L.pneumophila can be detected in pleural fluid, sputum, or lung tissue by direct fluorescent antibody microscopy.
Who is L.pneumophila most seen in? middle-aged men who smoke
What is Chlamydia psittaci? a small gram(-) bacteria in the respiratory tract and feces of a variety of birds
How is C. psittaci transmitted? from bird to human through aerosol or direct contact
The clinical manifestations on C. psittaci closely resemble those caused by what other Atypical bacteria? M. pneumoniae
What is Chlamydia pneumoniae? recently identified as a cause of pneumonia in adults
What is C. pneumoniae associated with? meningoencephalitis, myocarditis, endocarditis, CAD, and Guillain-Barre syndrome
The major anaerobic organisms associated with pneumonia are Peptostreptococcus
5 organisms in the Peptostreptococcus class Bacteroides melaninogenicus, Fusobacterium necrophorum, Bacteroides asaccharolyticus, Porphyromonas endodontalis, and Porphyromonas gingivalis
What is the major cause of anaerobic lung infections? aspiration of oropharyngeal secretions and gastric juices
What are some predisposing risk factors of aspiration? decreased LOC, impaired swallowing, poor dental hygeine, and GI abnormalities
Aspiration pneumonia is often _______ multimicrobial
What are viruses? parasites, cant live without host, DNA or RNA, cant culure in a lab, most common cause of pneumonia in children.
URI = __%viral 90
LRI = __% viral 50
5 viral causes of pneumonia Influenza virus, Respiratory Syncytial Virus, Parainfluenza virus, Adenovirus, and Coronavirus
Which 2 types of influenza virus are the most common causes of Respiratory tract infections? type A and type B
What is the incubation period of the influenza virus? 1-3 days
What is often the first sign of an influenza epidemic? school absenteeism
What is the Respiratory syncytial virus(RSV)? a member of the paramyxovirus group and is most often seen in children less than 12 months of age and in older adults with underlying heart or pulmonary disease in winter and spring
RSV often goes unrecognized but may play an important role as a forerunner to bacterial infections
What 4 viruses belong to the paramyxovirus group? RSV, parainfluenza virus, mumps and rubella virus
There are 5 types of parainfluenza virus but which 3 types are the major causes of infections of humans? Type 1, 2, and 3
Which parainfluenza virus type is considered a croup type virus 1
parainfluenza Type 2 and 3 are associated with ______ infections severe
Which parainfluenza virus type is most seen in infacnts younger than 2 months and in the late spring and summer? type 3
Which parainfluenza virus type(s) are seen most often in children between the ages of 6 month and 5 years and occurs in the fall? Typers 1 and 2
Parainfluenza viruses are known for what? their ability to spread rapidly among members of the same family
There are more than __ adenovirus subgroups 30
Which adenovirus serotypes cause viral infections and pneumonia in all age groups? Serotypes 4, 7, 14, and 21
This adenovirus serotype has been related to fatal cases of pneumonia in children? serotype 7
This is a newly recognized virus strain that causes SARS coronavirus
What is SARS? severe acute respiratory syndrome, highly contagious but rare mortality
What is the incubation period for SARS? 2-7 days
Where was the first case of SARS? China 2002
According to the CDC, __-___% of SARS patients require mechanical ventilation 10-20%
Rickettsiae, Varivella, and Rubella are causes of what type of Pneumonia? Viral
Name 3 illnesses the Rickettsiae virus causes? Rocky mountain spotted fever, Q fever, and Typhus.
What is the mode of transmission for Typhus? vectors and raw milk
What is aspiration pneumonitis? serious and fatal pneumonia, inflammation seen 12-26 hours after aspiration, leads to ARDS in 24-48 hours.
What is gastric pH? <2.5
What are some clinical mainfestations of aspiration pneumonitis? Mendelson’s syndrome 1946, Tachycardia, dyspnea, cyanosis
What is Mendelson’s syndrome? The aspiration of stomach contents into the lungs during obstetric anesthesia
What disease is 3x’s more prevalent in asthma and may be a cause of asthma? GERD
Tests for GERD? modified barium swallow test, and Evan’s blue dye test
What is the percentage of trach patients that have silent aspiration? 55-70%
What is the cause of silent aspiration in trach patients? inflated cuff impairs swallowing
What was originally defined as “Disease predictive of defect in cell-mediated immunity, occuring in persons with no known resistance to that disease”? AIDS
What is AIDS no viewed as? end stage manifestations of prolonged chronic erosion of immune system, late stage HIV infection
When was the lowest incidence of TB? 1980’s
What caused is the Tb organism? Mycobacterium tuberculosis
What is Mycobacterium tuberculosis and where in the lung is it found? slender, rod shaped aerobic organism found in apices of lung
Predisposing factors for TB infection homeless, drug abuse, AIDS
According to the WHO b/w 2000-2020 there will be __ new cases and ____ million will die 1 billion; 35 million
__%of people test positive on a PPD test but are not really infected 20%
Most fungal infections are from ______organisms and occur in the _____ of the lungs aerobic; apices
Who is most at risk for fungal pneumonia? Aids and steroid therapy
5 fungal infections/ organisms Histoplasma capsulatum, Coccidiodes immitis, Blastomyces dermatidis, Candida albicans, Aspergillus fumigatus
Where can you get Aspergillus fumigatus from? barns, silos, granaries
What are the 4 locations or methods of exposure to acquired pneumonia? Community acquired, Hospital acquired, Ventilator acquired, and Nursing home acquired
What are the primary pathophysiologic mechanisms caused by consolidation from pneumonia? immune response(inflammatory), decreased V/Q ratio, pulmonary shunting, venous admisture, hypoxemia; decreased lung capacity, increased lung density
What are the secondary pathophysiologic mechanisms caused by consolidation from pneumonia? Stimulation of O2 receptors; deflation reflex, irritant reflex
What trreatment is used for sonsolidation? no specific treatment modality
What are the primary pathophysiologic mechanisms caused by atelectasis? decreased V/Q ratio, pulmonary shunting, venous admisture, hypoxemia; reversible decreased lung compliance, increased lung density
What are the secondary pathophysiologic mechanisms caused by atelectasis from pneumonia? Stimulation of O2 receptors; deflation reflex, irritant reflex
Atelectasis Tx? hyperinflation protocol therapy
Created by: Dabi
 

 



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