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CNS 1
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| Generic | Brand | Category | Indications | Side Effects | US Box Warning | Other Notes |
|---|---|---|---|---|---|---|
| mirtazepine (PO) | Remeron | Alpha2 antagonist | MDD | drowsiness, weight gain, xerostomia, increased appetite, constipation | increase risk of suicidal thinking and behavior in children, adolescents, and young adults | |
| bupropion (PO) | Wellbutrin SR, Wellbutrin XL | Norepinephrine-dopamine reuptake inhibitor | MDD | tachycardia, headache, agitation, dizziness, insomnia, weight loss, xerostomia | increased risk of suicidal thinking and behavior in children, adolescents, and young adults; serous neuropsychiatric reactions have occurred | use may increase risk of seizures (CI in patients with seizure disorders and/or eating disorders) |
| atomoxetine (PO) | Strattera | Selective norepinephrine reuptake inhibitor | ADHD | hypertension, tachycardia, headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia | increased risk of suicidal ideation in children or adolescents | CI within 14 days of MAOI |
| desvenlafaxine (PO) | Pristiq | Serotonin-norepinephrine reuptake inhibitor (SNRI) | MDD | headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia, diaphoresis, hypertension, sexual dysfunction | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI |
| duloxetine (PO) | Cymbalta | Serotonin-norepinephrine reuptake inhibitor (SNRI) | MDD, neuropathic pain | headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia, diaphoresis, hypertension, sexual dysfunction | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI |
| venlafaxine (PO) | Effexor-XR | Serotonin-norepinephrine reuptake inhibitor (SNRI) | MDD | headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia, diaphoresis, hypertension, sexual dysfunction | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI |
| citalopram (PO) | Celexa | Selective-serotonin reuptake inhibitor (SSRI) | MDD | drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |
| fluoxetine (PO) | Prozac | Selective-serotonin reuptake inhibitor (SSRI) | MDD | drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI |
| escitalopram (PO) | Lexapro | Selective-serotonin reuptake inhibitor (SSRI) | MDD | drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |
| paroxetine (PO) | Paxil | Selective-serotonin reuptake inhibitor (SSRI) | MDD | drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |
| sertraline (PO) | Zoloft | Selective-serotonin reuptake inhibitor (SSRI) | MDD | drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |
| trazodone (PO) | Desyrel | Serotonin reuptake inhibitor | Insomnia, MDD | sedation, headache, dizziness, xerostomia, nausea, priapism | increased risk of suicidal thinking and behavior in children, adolescents and young adults | |
| amitriptyline (PO) | Elavil | Tricyclic antidepressant (TCA) | MDD, diabetic neuropathy, migraine prophylaxis | dizziness, drowsiness, orthostatic hypotension, sexual dysfunction, xerostomia, blurred vision, constipation | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |
| nortriptyline (PO) | Pamelor | Tricyclic antidepressant (TCA) | MDD, diabetic neuropathy, migraine prophylaxis | dizziness, drowsiness, orthostatic hypotension, sexual dysfunction, xerostomia, blurred vision, constipation | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |
| doxepin (PO) | Silenor | Tricyclic antidepressant (TCA) | Insomnia | somnolence, sedation, nausea | increased risk of suicidal thinking and behavior in children, adolescents, and young adults | CI within 14 days of MAOI; do not discontinue abruptly |