Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Pain/Heme/Onc 3
with essential knowledge
| Generic | Brand | Category | Indications | Side Effects | US Box Warning | US Box Warning (PT2) | Other Notes |
|---|---|---|---|---|---|---|---|
| methotrexate (PO, IV, IT) | Trexall | Antimetabolite (folic acid antagonist) | Rheumatoid arthritis, Crohn's Disease, psoriasis, various hematologic and solid tumors | stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis (rare) | Serious toxicity; use only for life-threatening neoplastic disease, severe psoriasis, or severe RA. Pregnancy: may cause fetal death/congenital abnormalities; avoid. Severe/fatal bone marrow suppression, aplastic anemia&GI toxicity w/NSAIDs. | Hepatotoxicity; acute/chronic interstitial pneumonitis; hypersensitivity. IT/high-dose therapy: use preservative-free formulation to prevent CNS toxicity or metabolic acidosis. | folic acid supplementation may be taken during use to reduce hematologic, gastrointestinal, and hepatic side effects |
| cisplatin (IV, IT, IP) | Kemoplat | Antineoplastic agent, platinum-based compound | Advanced bladder, ovarian, and testicular cancer; various cancers | bone marrow suppression, nausea/vomiting, nephrotoxicity, neurotoxicity, ototoxicity | may cause severe myelosuppression, severe nausea/ vomiting (requires highly effective antiemetic premedication), renal toxicity, and dose-related neuropathy | ||
| doxorubicin (IV) | Adriamycin | Antineoplastic agent, anthracycline | Adjuvant therapy for breast cancer, various cancers | cardiomyopathy, alopecia, nausea, vomiting, bone marrow suppression | may cause cardiomyopathy, myelosuppression, secondary malignancies; extravasation can result in severe local tissue injury and necrosis | may cause red discoloration of urine, tears, sweat, and saliva | |
| pembrolizumab (IV), pembrolizumab/ berahyaluronidase alfa-pmph (SC) | Keytruda(IV), Keytruda Qlex (SC) | Antineoplastic agent, monoclonal antibody | Various cancers | peripheral edema, immune-related adverse events (pruritus, skin rash, endocrine/metabolic abnormalities, diarrhea, increased liver enzymes, increased serum creatinine, dyspnea), nausea, vomiting, hematuria, anemia, fatigue, musculoskeletal pain | |||
| anastrozole (PO) | Arimidex | Aromatase inhibitor | Hormone receptor-positive breast cancer | fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis | cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy) | ||
| tamoxifen (PO) | Soltamox | Selective estrogen receptor modulator (SERM) | Hormone receptor-positive breast cancer | hot flashes/night sweats, vaginal bleeding/discharge, decreased bone density (in premenopausal females) | increased risk for uterine or endometrial cancer and thromboembolic events | contraception should be used in premenopausal females due to teratogenicity of the drug; do not use with warfarin or history DVT/PE |
Created by:
salmouie