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Pain/Heme/Onc 2

with essential knowledge

GenericBrandCategoryIndicationSide EffectsUS Box WarningOther Notes
hydrocodone and acetaminophen (PO) (CS-II) Lortab, Vicodin, Norco Opioid and nonopioid analgesic combination Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) Opioids risk addiction, misuse, fatal overdose, respiratory depression, accidental-ingestion death, neonatal or abrupt-discontinuation withdrawal, and when combined with benzodiazepines, alcohol, or other CNS depressants, sedation, coma, and death. US Box Warning: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity
oxycodone and acetaminophen (PO) (CS-II) Percocet, Endocet Opioid and nonopioid analgesic combination Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) Opioids risk addiction, misuse, fatal overdose, respiratory depression, accidental-ingestion death, neonatal or abrupt-discontinuation withdrawal, and when combined with benzodiazepines, alcohol, or other CNS depressants, sedation, coma, and death. US Box Warning: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity
codeine and acetaminophen (PO) (CS-III) Tylenol with Codeine #3, Tylenol with Codeine #4 Opioid and nonopioid analgesic combination Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) Opioids risk addiction, misuse, fatal overdose, respiratory depression, accidental-ingestion death, neonatal or abrupt-discontinuation withdrawal, and when combined with benzodiazepines, alcohol, or other CNS depressants, sedation, coma, and death. USBW: concomitant use/discontinuation of CYP3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors needs careful consideration; respiratory depression&death in children after tonsillectomy/ adenoidectomy who are rapid metabolizers of codeine; hepatotoxicity
naloxone (IV, IM, SQ, intranasal) Narcan Nasal Spray, Zimhi Opioid antagonist Opioid overdose opioid withdrawal syndrome in opioid-dependent populations, pain
buprenorphine and naloxone (SL) (CS-III) Suboxone Partial opioid agonist and opioid antagonist Opioid use disorder opioid withdrawal syndrome in opioid-dependent populations, constipation, headache, diaphoresis potentially life-threatening respiratory depression (when combined with other CNS and respiratory depressants); addition of naloxone to buprenorphine reduces the possibility of parenteral misuse by producing opioid withdrawal symptoms when injected
ferrous sulfate (PO) (OTC) FeroSul, SlowFe Iron supplement Iron deficiency anemia nausea, stomach upset, constipation (dose-related), dark and tarry stools accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old
cyanocobalamin (vitamine B12) (PO, IM, SL, intranasal) --- Water-soluble vitamin Vitamin B12 deficiency (manifests as macrocytic anemia) no major side effects
folic acid (PO) (OTC) --- Water-soluble vitamin Folic acid deficiency (manifests as macrocytic anemia), prevention of neural tube defects in pregnancy no major side effects
Created by: salmouie
 

 



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