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Endocrine 2
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| Generic | Brand | Category | Indications | Side Effects | US Box Warning | Other Notes |
|---|---|---|---|---|---|---|
| drospirenone and ethinyl estradiol (PO) | Yasmin 28, Yaz | Contraceptive | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | increased risk of cardiovascular events in women >35 years old who smoke | CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| levonorgestrel and ethinyl estradiol (PO) | Lutera, Levora, Seasonique | Contraceptive | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | increased risk of cardiovascular events in women >35 years old who smoke | CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| norethindrone and ethynyl estradiol (PO) | Junel, Loestrin, Microgestin | Contraceptive | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | increased risk of cardiovascular events in women >35 years old who smoke | CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| norethindrone, ethinyl estradiol, and ferrous fumarate (PO) | Lo Loestrin Fe, Microgestin Fe | Contraceptive | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | increased risk of cardiovascular events in women >35 years old who smoke | CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| norgestimate and ethinyl estradiol (PO) | Tri-Sprintec, Sprintec | Contraceptive | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | increased risk of cardiovascular events in women >35 years old who smoke | CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| norgestrel and ethinyl estradiol (PO) | Crysell-28, Low-Ogestrel | Contraceptive | Contraception, acne | nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache, weight gain | increased risk of cardiovascular events in women >35 years old who smoke | CI in hepatic dysfunction, thromboembolic disorders, breast cancer, migraines with aura, and cardiovascular disease |
| estrogens, conjugated (equine) (PO, topical) | Premarin | Estrogen derivative | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | irritation at application site (transdermal patch only), edema, abdominal pain, breast tenderness, weight gain, thromboembolic disorders (myocardial infarction, stroke, VTE) | increased risk of breast cancer; should not be used for dementia prevention; increased risk of endometrial cancer if not used concomitantly with progestin in women with a uterus; should not be used for prevention of cardiovascular disease | CI in hepatic dysfunction, thromboembolic disorders, cardiovascular disease, breast cancer, and estrogen-dependent tumor |
| estradiol (transdermal, PO) | Transdermal: Climara, Vivelle Dot PO: Estrace | Estrogen derivative | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | irritation at application site (transdermal patch only), edema, abdominal pain, breast tenderness, weight gain, thromboembolic disorders (myocardial infarction, stroke, VTE) | increased risk of breast cancer; should not be used for dementia prevention; increased risk of endometrial cancer if not used concomitantly with progestin in women with a uterus; should not be used for prevention of cardiovascular disease | CI in hepatic dysfunction, thromboembolic disorders, cardiovascular disease, breast cancer, and estrogen-dependent tumor |
| medroxyprogesterone (PO) | Provera | Progestin | Abnormal uterine bleeding, secondary amenorrhea | acne, abnormal menstrual bleeding, headache, amenorrhea, weight gain | increased risk of breast cancer; should not be used for dementia prevention; should not be used for prevention of cardiovascular disease | CI in thromboembolic disorders, cardiovascular disease, estrogen or progesterone-dependent tumors, undiagnosed abnormal genital bleeding, hepatic impairment |