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PCOL Drug List

DrugMOASOASEKI
Acetylcholine Depolarizing agent/ agonist All over body DUMBELSS (agonist) DUMBELLS
Vernicline a4/b2 Nn partial agonist CNS/ Nn Headache suicidal thoughts, depression, flatulence BBW
Succinylcholine Depolarizing agent NMJ/ Nm NMJ paralysis (agonist) P1: Ach bind to open Na channels/ P2: Blocks Na channels
Physostigmine Cholinesterase Inhibitor/ Indirect antagonist CNS & Periphery DUMBBELSS (agonist) Tx for Anti muscarini poisioning
Donepezil Cholinesterase Inhibitor/ Indirect antagonist CNS & Periphery DUMBBELSS (agonist) Lipophilic -> Cross BBB / Dementia/ Alzheimer
Rivastigmine Cholinesterase Inhibitor/ Indirect antagonist CNS & Periphery DUMBBELSS (agonist) Lipophilic -> Cross BBB / Dementia/ Alzheimer
Galantamine Cholinesterase Inhibitor/ Indirect antagonist CNS & Periphery DUMBBELSS (agonist) Lipophilic -> Cross BBB / Dementia/ Alzheimer
Pyridostigmine Cholinesterase Inhibitor/ Indirect antagonist NMJ DUMBBELS (agonist)/ No CNS effects Do not cross BBB Reverse effects of Curare/tx of myasthenia graves
Neostigmine Cholinesterase Inhibitor/ Indirect antagonist NMJ DUMBBELS (agonist)/ No CNS effects Do not cross BBB Reverse effects of Curare/tx of myasthenia graves
Edrophonium Cholinesterase Inhibitor/ Indirect antagonist NMJ DUMBBELS (agonist)/ No CNS effects Diagnosis of myasthenia gravis or medication adjustment Short duration of action
Echothiopate Organophosphate inhibitor of ACHesterase enzyme/ Indirect antagonist M3 receptor in ciliary muscle (eye) Miosis, blurred vision, lacrimation, stinging/red eye Ophthalmology tx glaucoma
Botulinum Toxin Prevent ACh release/ Antagonist Presynaptic terminal Muscle relaxation Cleaves sites on SNARE protein
Curare & Curare like (-cur-) Non-depolarizing agents/ Antagonist Direct comp antagonist NMJ NMJ Paralysis, Histamine release, hypotension & tachycardia No CNS effect Doesn't let Ach to bind
Acetylcholine/ Methacholine/Carbachol/Bethanechol Non-selective/ Muscarinic Agonist (M1, M2, M3 agonist) Central and periphery DUMBBELSS
Created by: jcresend
 

 



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