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Pyrazinamide

QuestionAnswer
Pyrazinamide T/P Antitubercular, antimycobacterial
Pyrazinamide adverse effects Hepatotoxic, hyperuricemia, gout, G1 upset, rash, monitor uric acid, renal function, may be taken with food if stomach upset
Pyrazinamide report Dark urine, jaundice, fatigue, N/V, appetite, gout/uric acid, joint pain/swelling, rash
Ethambutol T/P ANti mycobacterial, helps prevent drug resistance
adverse effects of ethambutol optic neuritis
Nursing considerations for ethambutol Decreased visual acuity, altered red/green color discrimination, blurred vision. May take with food if GI upset. Monitor renal function.
Streptomycin Antitubercular, aminoglycoside, second line defense for multi-drug resistance. Used with other antitubercular meds.
Adverse effects of streptomycin Ototoxicity, nephrotoxicity, neuromuscular toxicity/blockade, injection site reaction, PMC, superinfection
Nursing safety for streptomycin Monitor BUN, creatinine/eGFR and urine output. Monitory daily weights for kidney function. Monitor serum drug concentrations, trough levels before next dose to monitor accumulation.
Report streptomycin Decreased urine output, rapid unexpected weight gain or edema, ringing/buzzing in the ears or decreased hearing, changes.
Pyroxidine administered with INH, helps prevent neuropathy, high levels cna cause reverse neuropathy.
Created by: pharm3studysets
 

 



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