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Rifampin/Isoniazid

Rifampin

QuestionAnswer
Rifampin T/P T: Inhibits bacterial RNA synthesis P: Multidrug therapy for tuberculosis
Rifampin adverse Hepatotoxic, GI upset, N/V/D, flu like reaction, red discoloration of excretions, severe PMC, AKI
Rifampin interactions Strong enzyme inducer, can decrease effectiveness of many medications, oral contraceptives, warfarin, corticosteroids, methadone
What should be avoided in Rifampin Alcohol, orange excretions are expected.
Isoniazid T/P Antitubercular, mycolic acid inhibitor, part of multridrug therapy
Isoniazid adverse Hepatotoxic, peripheral neuropathy, neurotoxicity, coordination, tremors, and seizures, optic neuritis, blurred vision,
Nursing considerations for isoniazid Pyridoxine helps treat INH associated neuropathy. Take on an empty stomach, 1 hr before meals or 2 hours after. Complete entire regimen.
Isoniazid can interfere with Metabolism of tyramine and histamine in aged cheeses, fish. Report flushing, swelling, and palpitations.
Created by: pharm3studysets
 

 



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