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Entacapone

QuestionAnswer
Entacapone T/P T: Antiparkinson agent P:L Catecholo O methyltransferase inhibitor
MOA of Entacapone Selectively and reversily inhibits catechol - O methyltransferase
What is Entacapone used for? Parkinsons; it prolongs the effects of levadopa
Adverse effects of Entacapone Brown urine, dyskinesia
Serious reactions to Entacapone NMS, Rhabdo, pulomonary infiltrates, retroperitoneal fibrosis, hypotension
Contraindications to Entacapone Hypersensitivity, non selective MAOI therapy, psychotic disorder
Precautions to Entacapone Use cautiously in hepatic impairment, can cause increased HR/BP with other COMT, may interfere with biliary elimination of drug
What is it administered alongside? It is administered alongside levodopa/carbidopa. Monitor for parkinsonian symptoms, EPS, NMS, dyskinesia, wean gradually.
Created by: pharm3studysets
 

 



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