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pcol exam 2 drug lis

DRUGMOASOASE/ADRsother shit
Acetylcholine Nicotinic & Muscarinic Depolarizing agent (agonist) all over body DUMBBELSS Diarrhea, Urination, Miosis, Bradycardia, Bronchial constrictions, Emesis, Lacrimation, Salivation, Stimulation (CNS)
Varenicline alpha 4/beta 2 Nn partial agonist CNS (Nn) Headache, insomnia, suicidal thoughts, depression, flatulence FDA warning of mod and behavioral changes; used for smoking cessation
succinylcholine depolarizing agent (agonist) (Neuromuscular blockade - nicotinic) NMJ (NM) can affect autonomic (PNS/SNS) ganglia NMJ paralysis (agonist) Hyperkalemia, HTN & arrhythmias, muscle pain (myalgia), hyperthermia phase 1: binds to Ach binding space and keeps all Na+ channels open (cannot repolarize) phase 2: blocks Na+ channels (cannot depolarize)
Physostigmine (indirect antagonist) Cholinesterase inhibitor (AChE antagonist)(indirect antagonist) CNS & periphery DUMBBELSS (agonist) penetrates CVS/cross BBB treatment for antimuscarinic poisoning (atropine)
Donepezil (indirect antagonist) Rivastigmine (Exelon)(indirect antagonist) Cholinesterase inhibitor (AChE Antagonist)(indirect antagonist) CNS & periphery DUMBBELSS (agonist) Lipophilic -> cross BBB used for dementia/alzheimer's
Galantamine (indirect antagonist) longer 1/2 than physostigmine
PyriDOstigmine Neostigamine (indirect antagonist) cholinesterase inhibitor (AChE Antagonist) (Indirect agonist) NMJ DUMBBELS (agonist) no CNS effects DO NOT cross BBB Reverse the effects of Curare/treatment of myasthenia gravis
Edrophonium (indirect antagonist)
Created by: user-1965903
 

 



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