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Pharmacology Exam 2

Pharmacology Exam 2 Drug List

Drug MOASOASide Effects/ADR Section
Acetylcholine (agonist) Nicotinic and Muscarinic depolarizing agent All over body DUMBBELSS Neuromuscular
Varenicline (agonist) a4/b2 Nn partial agonist CNS (Nn) Headache, insomnia, suicidal thoughts, depression, flatulence Neuromuscular
Succinylcholine (agonist) Depolarizing agent (neuromuscular blockade-nicotinic) NMJ (Nm)/can affect autonomic PSNS/SNS ganglia NMJ paralysis; Hyperkalemia, HTN & arrythmias, muscle pain (myalgia), hyperthermia Neuromuscular
Physostigmine (indirect antagonist) Cholinesterase Inhibitor (AChE Antagonist/indirect antagonist) CNS & periphery DUMBBELSS Neuromuscular
Donepezil/Rivastigmine/Galantamine (indirect antagonist) Cholinesterase Inhibitor (AchE Antagonist/indirect antagonist) CNS & periphery DUMBBELSS Neuromuscular
PyriDOstigmine/Neostigimine (indirect antagonist) Cholinesterase Inhibitor (AchE Antagonist/indirect antagonist) NMJ DUMBBELSS *NO CNS EFFECTS Neuromuscular
Edrophonium (indirect antagonist) Cholinesterase Inhibitor (AchE Antagonist/indirect antagonist) NMJ DUMBBELSS *NO CNS EFFECTS Neuromuscular
Echothiopate (indirect antagonist) Organophosphate inhibitor of acetylcholinesterase enzyme (indirect antagonist) M3 receptor in ciliary muscle (eye) Miosis and blurred vision, lacrimation, stinging/redness of eye Neuromuscular
Botulinum Toxin (Botox; antagonist) Prevent Ach release Presynaptic terminal Muscle relaxation Neuromuscular
Curare & Curare like (antagonist): Mivacurium Vecuronium Rocuronium Pancuronium Tubocurarine NON-depolarizing agent (antagonist) *Direct competitibe antagonist -> Binds to Ach binding space NMJ NMJ Paralysis *Histamine release, hypotension and tachycardia *NO CNS EFFECT Neuromuscular
Acetylcholine/Methacholine/Carbachol/Bethanechol (agonist) Non-selective Muscarinic Agonist (M1, M2, M3) Central and periphery DUMBBELSS Cholinergic
Pilocarpine/Cevimeline (agonist) Non-selective Muscarinic agonist (M1. M2, M3) Central and periphery DUMBBELSS Cholinergic
Atropine (antagonist) Non-selective Muscarinic antagonist (M1, M2, M3) Central and periphery Anti-DUMBBELSS Cholinergic
Scopolamine (antagonist) Non-selective Muscarinic antagonist (M1, M2, M3) CNS-penetrate CNS more rapidly Anti-DUMBBELSS *anti-emesis Cholinergic
Benztropine (antagonist) Non-selective Muscarinic antagonist (M1, M2, M3) CNS Anti-DUMBBELSS Cholinergic
Tropicamide (antagonist) Muscarinic Antagonist Eyes Anti-DUMBBELSS Cholinergic
Ipratropium (antagonist) Non-selective Muscarinic antagonist (M1, M2, M3) Lungs Anti-DUMBBELSS Cholinergic
Tiotropium (antagonist) SELECTIVE Muscarinic antagonist (M1 & M3) Lungs Anti-DUMBBELSS Cholinergic
Aclidinium/Umeclidium (antagonist) Muscarinic antagonist Lungs Anti-DUMBBELSS Cholinergic
Oxybutynin, Tolterodine, Solfenacin, Fesoterodine, Darifenacin (antagonists) Non-selective Muscarinic antagonist (M1, M2, M3) M3 in bladder Anti-DUMBBELSS Xerostomia and Constipation Cholinergic
Nitroglycerine/Nitroprusside/Isosorbide/mononitrate (donors) Donate nitric oxide NO-> sGC-> inc CAMP Endothelium of blood vessels (M3) Vasodilation Lower BP Cholinergic
Sildenafil/Tadalafil/Vardenafil (indirect antagonist) Blocks PDE -> inc cGMP Endothelium of blood vessels (M3) Vasodilation Lower BP Cholinergic
Phenylephrine (agonist) a1 agonist Blood vessels, eyes HTN, Burning and nasal discharge, rebound congestion Adrenergic
Cocaine (indirecr antagonist) NE reuptake inhibitor CNS HTN, tachycardia, arrythmias, restlessness Adrenergic
Dextroamphetamine and amphetamine/Methylphenidate/Lisdexamphetamine/Dexmethylphenidate (indirect antagonists) Stimulate pre-synaptic release of NE & DA CNS HTN, tachycardia, arrythmias, restlessness, loss of appetite Adrenergic
Phenelzine (indirect antagonist) Non-selective MOA-A & MOA-B irreversable antagonist CNS HTN, tachycardia, arrythmias,restlessness Adrenergic
Selegiline, Rasagiline (indirect antagonist) SELECTIVE MAO-B irreversible antagonist CNS HTN, tachycardia, arrythmias, restlessness Adrenergic
Prasozin/ Terasozin/Dozasozin/Tamsulosin (alpha 1a antagonist:tamsulosin, all others: antagonists) Selective a1-antagonist (prazosin) all others reversible antagonists Brain, Eye, Nose, Blood Vessels, Urethra Headache, blurred vision orthostatic hypotension -> reflex tachycardia, sexual disfunction Adrenergic
Phenoxybenzamine (antagonist) Non-selective a1/2 antagonist Irreversable antagonist Dec peripheral resistance Brain, Eye, Nose, Blood vessels, urethra, GI Orthostatic hypotension -> reflex tachycardia GI stimulation (a2 on PNS fiber blocked) Headache. Miosis Adrenergic
Created by: Parra2321
 

 



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