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Chapter 14
Pain and Inflammation
| Question | Answer |
|---|---|
| Addison's disease | A disease or syndrome characterized by inadequate amounts of corticosteroid hormones. |
| Analgesia | The absence of the sensation of pain |
| Ceiling effect | The highest level of a specific drug has been reached; increasing the dose does not provide any additional pain relief but may increase the side effects. |
| Cushing's disease | Hyperadrenocorticism; a disease or syndrome characterized by an overabundance of corticosteroid hormones. |
| Histamine | A chemical mediator of the inflammatory response released from mast cells. Histamine may cause dilation and increased permeability of small blood vessels, constriction of small airways, increased secretion of mucus in the airways, and pain. |
| Modulation | The modification of nociceptive transmission. |
| Multimodal analgesia | The use of different drugs with different actions to produce optimal analgesia and minimize individual drug quantities when possible. |
| Nerve block | A loss of feeling or sensation produced by injecting an anesthetic agent around a nerve to interfere with its ability to conduct impulses. |
| Neuropathic pain | Pain that originates from injury or involvement of the peripheral or central nervous system. |
| Nociceptors | A receptor for pain caused by injury to body tissue. Pain sensation arises in the terminal ends of sensory nerve fibers. |
| Pathologic pain | Pain with an exaggerated response; it is often associated with tissue injury due to trauma or surgery. |
| Perception | The processing and recognition of pain in the cerebral hemispheres. |
| Physiologic Pain | The protective sensation of pain that allows individuals to move away from potential tissue damage. |
| Preemptive analgesia | Analgesia administered before the painful stimulus to help prevent sensitization and windup. |
| Somatic pain | Pain arising from bones, joints, muscle, or skin. Somatic pain is described in humans as localized, sharp, constant, aching, or throbbing. |
| Transdermal application | The use of a patch applied to the skin to deliver a drug through an intact cutaneous surface to the systemic circulation. |
| Transduction | The process that involves translation of noxious stimuli into electric activity at sensory nerve endings. |
| Transmission | Conduction of pain impulses from peripheral pain receptors to the spinal cord. |
| Visceral pain | Pain arising from stretching, distension, or inflammation of viscera, described in humans as deep, cramping, or aching and difficult to localize. |