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Hydroxyurea

QuestionAnswer
Hydroxyurea T,P T- Sickle cell anemia crisis P- Antineoplastic
Hydroxyurea MOA Inhibits DNA cell synthesis, increases fetal Hgb levels, rb water content, sickled cell deformability, and alters RBC adhesion to endothelium
What does Hydroxyurea decrease the need for? blood transfusions
Uses for Hydroxyurea Head and neck cancers, CMC, melanoma
Hydroxyurea off label uses thrombocythenmia, decreases pain in sickle cell disease
SE of Hydroxyurea N/V/D/C, anorexia, alopecia, rash, hepatitis, stomatitis, bone marrow suppression, asthenia
Damaged, sickled RBCs lead to Early destruction causing anemia
What is bone marrow suppresion? Causes neurtropenia, anemia, thrombocytopenia
Interactions with Hydroxyurea HIV meds, diclonosine, stovidine, can lead to increased hepatotoxicity
Contraindications to Hydroxyurea with other BM suppressive tx, or live viruses, or pregnancy
Labs to monitor for Hydroxyurea CBC, renal, LFTs
Nursing considerations for Hydroxyurea Access for infection, decrease dose for pts in renal disease, chemo precautions when handling body fluids, fluid intake 2-3L/day when taking for leukemia
What to avoid No alcohol, ASA, NSAIDs, Avoid pregnancy, breast feeding, leads to increased risk of skin cancer
Created by: pharm3studysets
 

 



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