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Clopidogrel

QuestionAnswer
Clopidogrel T, P T: Antiplatelet drug P: ADP receptor blocker
Clopidogrel MOA Prolongs bleeding time by inhibiting plately aggregation, directly inhibiting ADP if CYP450 is poor metabolizers, its less effective.
Uses for clopidogrel Decrease risk for CVA or MI, thrombus prophylaxis coronary stents/post dvt
Clopidogrel SE: Extensive bleeding, flu like symptoms, HA, dyspepsia, abdominal pain, dizziness, bruising, upper respiratory infections, rash pruritus.
Clopidogrel Interactions: Increased risk of bleeding with antithrombotics, ASA, NSAIDS, nCYP inhibitors, gingko, ginger, garlic
What agents diminish anti platelet action? ozole antifungals, protease inhibitors, erythromycin, verapamil, zaltilukast, fluoxetine, marijuana, PPIs
Contraindications to clopidogrel Patients with active bleed, severe hepatic disease
LABs Coags
Nursing instructions Do not crush or split, d/c at least 5 days prior to surgery, monitor for bleeding.
Created by: pharm3studysets
 

 



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