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Heparin
| Question | Answer |
|---|---|
| Heparin T, P | Heparin T: Anticoagulant P: Indirect thrombin inhibitor |
| MOA of heparin | Binds to antithrombin III, inactivation of thrombin and other clotting factors |
| Uses of heparin | prophylactic/treatment of thromboembolic event. Dialysis procedures, pts with unstable angina, acute stages on MI |
| SE of heparin | Extensive bleeding, HIT, thrombocytopenia |
| interactions with heparin | Antiplatelets, anticoagulations, thrombolytics, ASA, NSAIDs, defibrotide, milepristone |
| Contraindications to heparin | Active bleed, severe hepatic disease, severe HTN, renal disease, recent trauma, intracranial hemorrhage, bacterial endocarditis. |
| LABs for heparin | AST, ALT, fatty acids, cholosterol, triglycerides, monitor for s/s bleeding, v/s, labs, protamine sulfate. |
| RANDI | Razor (electric) Aspirin (Halt) Needle small gauge Decrease needle sticks Injury (protect from) Use soft bristled toothbrush |