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BDK Quiz 4
| Pharmacologic Category | Generic Name | Brand Name | Classification | Common Indications | Essential Knowledge |
|---|---|---|---|---|---|
| Beta-lactam antibiotic (natural penicillin) | penicillin V potassium (PO), penicillin G potassium (IV) | --- | Pharyngitis, SSTI, syphilis (IV/IM) Activity against: Streptococcus pyogenes, Treponema pallidum (syphilis) | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (aminopenicillin) | amoxicillin (PO) | --- | Otitis media, pharyngitis Activity against: Streptococcus pneumoniae, Streptococcus pyogenes | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic and beta-lactamase inhibitor | amoxicillin and clavulanate (PO) | Augmentin, Augmentin XR | Otitis media, bacterial sinusitis Activity against: MSSA, Streptococcus pneumoniae, anaerobes, Enterobacteriacae | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic and beta-lactamase inhibitor | ampicillin and sulbactam (IV) | Unasyn | DFI, IAI Activity against: MSSA, Streptococcus pneumoniae, anaerobes, Enterobacteriacae | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic and beta-lactamase inhibitor | piperacillin and tazobactam (IV) | Zosyn | HAP, VAP, DFI, IAI Activity against: Pseudomonas aeruginosa, anaerobes | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (first generation cephalosporin) | cephalexin (PO) | Keflex | SSTI Activity against: MSSA, Streptococcus pyogenes | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (first generation cephalosporin) | cefazolin (IV) | Ancef | Antimicrobial prophylaxis in surgery, CRBSI, SSTI Activity against: MSSA, Streptococcus pyogenes | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (second generation cephalosporin) | cefuroxime (IV, PO) | IV: Zinacef, PO: Ceftin | CAP, otitis media Activity against: Streptococcus pneumoniae, Haemophilus influenzae | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (third generation cephalosporin) | cefdinir (PO) | Omnicef | Otitis media, bacterial sinusitis Activity against: Streptococcus pneumoniae, Haemophilus influenzae | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (third generation cephalosporin) | ceftriaxone (IV, IM) | Rocephin | Meningitis, CAP, pyelonephritis Activity against: Streptococcus pneumoniae, Enterobacteriaceae | Key Side Effects: diarrhea, hypersensitivity reactions | |
| Beta-lactam antibiotic (fourth generation cephalosporin) | cefepime (IV) | Maxipime | Meningitis, VAP, HAP, pyelonephritis Activity against: Pseudomonas aeruginosa, Enterobacteriaceae | Key Side Effects: diarrhea, hypersensitivity reactions, seizures or encephalopathy with excessive doses | |
| Anticholinergic; Antispasmodic | dicyclomine (PO) | Bentyl | IBS | Key Side Effects: drowsiness, blurred vision, dizziness, xerostomia, constipation Other Notes: CI in gastrointestinal obstruction, reflux esophagitis, acute hemorrhage with cardiac instability, obstructive uropathy, glaucoma | |
| Guanylate cyclase C agonist | linaclotide (PO) | Linzess | IBS-C, opioid-induced constipation | Key Side Effects: diarrhea, abdominal pain US Boxed Warnings: do not use in patients <2 years of age (risk of death due to dehydration) Other Notes: contraindicated in mechanical gastrointestinal obstruction | |
| Osmotic laxative | polyethylene glycol 3350 (PO) | MiraLax | OTC | Constipation | Key Side Effects: abdominal cramping, electrolyte imbalance Other Notes: CI with bowel obstruction |
| Osmotic laxative | Lactulose (PO) | Enulose, Constulose | Constipation, hepatic encephalopathy | Key Side Effects: abdominal cramps, abdominal distention, diarrhea, flatulence | |
| Stimulant laxative | senna (PO) | Ex-Lax, Senokot | OTC | Constipation | Key Side Effects: abdominal cramping, electrolyte imbalance |
| Stool softener | docusate (PO) | Colace | OTC | Prevent straining during defecation | Other Notes: do not use with mineral oil |
| Corticosteroid | dexamethasone (PO, IV) | DexPak, DoubleDex | Inflammatory diseases, cerebral edema, CINV | Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use | |
| Corticosteroid | methylprednisolone (PO, IM, IV) | Medrol, Solu-Medrol | Inflammatory diseases, COPD exacerbation, asthma exacerbation, acute gout | Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use | |
| Corticosteroid | prednisolone (PO) | Orapred | Inflammatory diseases, COPD exacerbation, asthma exacerbation, acute gout | Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use | |
| Corticosteroid | prednisone (PO) | Deltasone, Rayos | Inflammatory diseases, COPD exacerbation, asthma exacerbation, acute gout | Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use | |
| Corticosteroid | hydrocortisone (PO, IV, topical) | Topical: Cortaid IV: Solu-Cortef | Topical: OTC | Topical: Inflammation, rash PO/IV: Acute illness, adrenal insufficiency | Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use |
| Histamine (H2) antagonist | famotidine (PO, IV) | Pepcid, Zantac 360 | PO: OTC | GERD, erosive esophagitis, SUP | Key Side Effects: headache, constipation, diarrhea, mental status changes |
| Dopamine (D2) antagonist | metoclopramide (PO, IV) | Reglan | Gastroparesis, GERD, nausea, vomiting | Key Side Effects: drowsiness, dystonia, akathisia, EPS, QTc prolongation, diarrhea, hyperprolactinemia US Boxed Warnings: may cause tardive dyskinesia, do not use >12 weeks Other notes: CI with GI obstruction, perforation, or hemorrhage | |
| Selective serotonin (5-HT3) antagonist | ondansetron (PO, IV) | Zofran, Zofran ODT, Zuplenz | Nausea, vomiting | Key Side Effects: headache, fatigue, constipation, QTc prolongation | |
| Histamine (H1) antagonist | promethazine (PO, IM, IV, PR) | Phenergan | Motion sickness, nausea, vomiting | Key Side Effects: drowsiness, dry mouth, blurred vision, QTc prolongation, EPS US Boxed Warnings: potential for fatal respiratory depression in patients < 2 years old; injection can cause peripheral extravasation (preferred parenteral route is IM) | |
| Histamine (H1) antagonist | meclizine (PO) | Bonine | OTC | Motion sickness, vertigo | Key Side Effects: drowsiness, dry mouth, blurry vision |
| Antidiarrheal | diphenoxylate and atropine (PO) | Lomotil | Diarrhea | Key Side Effects: nausea, confusion, drowsiness, dizziness, xerostomia, tachycardia, urinary retention Other notes: do not use in diarrhea associated with enterotoxin-producing bacteria or in children <6 years of age | |
| Proton pump inhibitor (PPI) | dexlansoprazole (PO) | Dexilant | GERD, PUD, erosive esophagitis, SUP | Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | |
| Proton pump inhibitor (PPI) | esomeprazole (PO, IV) | Nexium | PO: OTC | GERD, PUD, erosive esophagitis, SUP | Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) |
| Proton pump inhibitor (PPI) | lansoprazole (PO) | Prevacid | OTC | GERD, PUD, erosive esophagitis, SUP | Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) |
| Proton pump inhibitor (PPI) | omeprazole (PO) | Prilosec | OTC | GERD, PUD, erosive esophagitis, SUP | Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) |
| Proton pump inhibitor (PPI) | pantoprazole (PO, IV) | Protonix | GERD, PUD, erosive esophagitis, SUP | Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) | |
| Gastrointestinal protectant | sucralfate (PO) | Carafate | duodenal ulcers | Key Side Effects: constipation, bezoar formation Other Notes: take on an empty stomach; many drug interactions due to reducing absorption of other drugs | |
| Opioid analgesic | fentanyl (transdermal, IV) | Transdermal: Duragesic, IV: Sublimaze | CS-II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr |
| Opioid analgesic | hydromorphone (PO, IV) | Dilaudid | CS-II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr |
| Opioid analgesic | morphine (extended release) (PO) | MS Contin, Kadian | CS-II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr |
| Opioid analgesic | morphine (immediate release) (PO, IV, IM, PR) | IV: Duramorph, Infumorph | CS-II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr |
| Opioid analgesic | oxycodone (PO) | OxyContin, Roxicodone | CS-II | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr |
| Opioid analgesic | methadone (PO, IV) | Dolophine | CS-II | Opioid use disorder, severe chronic pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related), QTc prolongation US Boxed Warnings (all opioid analgesics): See above US Boxed Warnings (only for methadone): QTc interval prolongation and serious arrhythmia (Torsades de Pointes) have occurred during treatment; concomitant use with CYP3A4, 2B6, 2C19, or 2D6 (or stopping the same inducers) can increase methadone concentrations |
| Analgesic (non-opioid), antipyretic | acetaminophen (PO, PR, IV) | PO/PR: Tylenol, IV: Ofirmev | PO, PR: OTC | Pain, fever | Key Side Effects: nausea, vomiting, increased hepatic transaminases US Boxed Warnings: total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity |
| Central analgesic; partial opioid agonist | tramadol (PO) | Ultram, Ultram ER | CS-IV | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warnings: risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result |