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BDK Quiz 4

Pharmacologic CategoryGeneric NameBrand NameClassificationCommon IndicationsEssential Knowledge
Beta-lactam antibiotic (natural penicillin) penicillin V potassium (PO), penicillin G potassium (IV) --- Pharyngitis, SSTI, syphilis (IV/IM) Activity against: Streptococcus pyogenes, Treponema pallidum (syphilis) Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (aminopenicillin) amoxicillin (PO) --- Otitis media, pharyngitis Activity against: Streptococcus pneumoniae, Streptococcus pyogenes Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic and beta-lactamase inhibitor amoxicillin and clavulanate (PO) Augmentin, Augmentin XR Otitis media, bacterial sinusitis Activity against: MSSA, Streptococcus pneumoniae, anaerobes, Enterobacteriacae Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic and beta-lactamase inhibitor ampicillin and sulbactam (IV) Unasyn DFI, IAI Activity against: MSSA, Streptococcus pneumoniae, anaerobes, Enterobacteriacae Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic and beta-lactamase inhibitor piperacillin and tazobactam (IV) Zosyn HAP, VAP, DFI, IAI Activity against: Pseudomonas aeruginosa, anaerobes Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (first generation cephalosporin) cephalexin (PO) Keflex SSTI Activity against: MSSA, Streptococcus pyogenes Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (first generation cephalosporin) cefazolin (IV) Ancef Antimicrobial prophylaxis in surgery, CRBSI, SSTI Activity against: MSSA, Streptococcus pyogenes Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (second generation cephalosporin) cefuroxime (IV, PO) IV: Zinacef, PO: Ceftin CAP, otitis media Activity against: Streptococcus pneumoniae, Haemophilus influenzae Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (third generation cephalosporin) cefdinir (PO) Omnicef Otitis media, bacterial sinusitis Activity against: Streptococcus pneumoniae, Haemophilus influenzae Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (third generation cephalosporin) ceftriaxone (IV, IM) Rocephin Meningitis, CAP, pyelonephritis Activity against: Streptococcus pneumoniae, Enterobacteriaceae Key Side Effects: diarrhea, hypersensitivity reactions
Beta-lactam antibiotic (fourth generation cephalosporin) cefepime (IV) Maxipime Meningitis, VAP, HAP, pyelonephritis Activity against: Pseudomonas aeruginosa, Enterobacteriaceae Key Side Effects: diarrhea, hypersensitivity reactions, seizures or encephalopathy with excessive doses
Anticholinergic; Antispasmodic dicyclomine (PO) Bentyl IBS Key Side Effects: drowsiness, blurred vision, dizziness, xerostomia, constipation Other Notes: CI in gastrointestinal obstruction, reflux esophagitis, acute hemorrhage with cardiac instability, obstructive uropathy, glaucoma
Guanylate cyclase C agonist linaclotide (PO) Linzess IBS-C, opioid-induced constipation Key Side Effects: diarrhea, abdominal pain US Boxed Warnings: do not use in patients <2 years of age (risk of death due to dehydration) Other Notes: contraindicated in mechanical gastrointestinal obstruction
Osmotic laxative polyethylene glycol 3350 (PO) MiraLax OTC Constipation Key Side Effects: abdominal cramping, electrolyte imbalance Other Notes: CI with bowel obstruction
Osmotic laxative Lactulose (PO) Enulose, Constulose Constipation, hepatic encephalopathy Key Side Effects: abdominal cramps, abdominal distention, diarrhea, flatulence
Stimulant laxative senna (PO) Ex-Lax, Senokot OTC Constipation Key Side Effects: abdominal cramping, electrolyte imbalance
Stool softener docusate (PO) Colace OTC Prevent straining during defecation Other Notes: do not use with mineral oil
Corticosteroid dexamethasone (PO, IV) DexPak, DoubleDex Inflammatory diseases, cerebral edema, CINV Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use
Corticosteroid methylprednisolone (PO, IM, IV) Medrol, Solu-Medrol Inflammatory diseases, COPD exacerbation, asthma exacerbation, acute gout Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use
Corticosteroid prednisolone (PO) Orapred Inflammatory diseases, COPD exacerbation, asthma exacerbation, acute gout Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use
Corticosteroid prednisone (PO) Deltasone, Rayos Inflammatory diseases, COPD exacerbation, asthma exacerbation, acute gout Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use
Corticosteroid hydrocortisone (PO, IV, topical) Topical: Cortaid IV: Solu-Cortef Topical: OTC Topical: Inflammation, rash PO/IV: Acute illness, adrenal insufficiency Key Side Effects: hyperglycemia, increased appetite with weight gain, depression, irritability, anxiety, restlessness, insomnia, osteoporosis (chronic use), Cushing's syndrome (chronic use) Other Notes: risk of adrenal suppression with prolonged use
Histamine (H2) antagonist famotidine (PO, IV) Pepcid, Zantac 360 PO: OTC GERD, erosive esophagitis, SUP Key Side Effects: headache, constipation, diarrhea, mental status changes
Dopamine (D2) antagonist metoclopramide (PO, IV) Reglan Gastroparesis, GERD, nausea, vomiting Key Side Effects: drowsiness, dystonia, akathisia, EPS, QTc prolongation, diarrhea, hyperprolactinemia US Boxed Warnings: may cause tardive dyskinesia, do not use >12 weeks Other notes: CI with GI obstruction, perforation, or hemorrhage
Selective serotonin (5-HT3) antagonist ondansetron (PO, IV) Zofran, Zofran ODT, Zuplenz Nausea, vomiting Key Side Effects: headache, fatigue, constipation, QTc prolongation
Histamine (H1) antagonist promethazine (PO, IM, IV, PR) Phenergan Motion sickness, nausea, vomiting Key Side Effects: drowsiness, dry mouth, blurred vision, QTc prolongation, EPS US Boxed Warnings: potential for fatal respiratory depression in patients < 2 years old; injection can cause peripheral extravasation (preferred parenteral route is IM)
Histamine (H1) antagonist meclizine (PO) Bonine OTC Motion sickness, vertigo Key Side Effects: drowsiness, dry mouth, blurry vision
Antidiarrheal diphenoxylate and atropine (PO) Lomotil Diarrhea Key Side Effects: nausea, confusion, drowsiness, dizziness, xerostomia, tachycardia, urinary retention Other notes: do not use in diarrhea associated with enterotoxin-producing bacteria or in children <6 years of age
Proton pump inhibitor (PPI) dexlansoprazole (PO) Dexilant GERD, PUD, erosive esophagitis, SUP Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD)
Proton pump inhibitor (PPI) esomeprazole (PO, IV) Nexium PO: OTC GERD, PUD, erosive esophagitis, SUP Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD)
Proton pump inhibitor (PPI) lansoprazole (PO) Prevacid OTC GERD, PUD, erosive esophagitis, SUP Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD)
Proton pump inhibitor (PPI) omeprazole (PO) Prilosec OTC GERD, PUD, erosive esophagitis, SUP Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD)
Proton pump inhibitor (PPI) pantoprazole (PO, IV) Protonix GERD, PUD, erosive esophagitis, SUP Key Side Effects: headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD)
Gastrointestinal protectant sucralfate (PO) Carafate duodenal ulcers Key Side Effects: constipation, bezoar formation Other Notes: take on an empty stomach; many drug interactions due to reducing absorption of other drugs
Opioid analgesic fentanyl (transdermal, IV) Transdermal: Duragesic, IV: Sublimaze CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr
Opioid analgesic hydromorphone (PO, IV) Dilaudid CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr
Opioid analgesic morphine (extended release) (PO) MS Contin, Kadian CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr
Opioid analgesic morphine (immediate release) (PO, IV, IM, PR) IV: Duramorph, Infumorph CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr
Opioid analgesic oxycodone (PO) OxyContin, Roxicodone CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warnings (all opioid analgesics): risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; abrupt discontinuation may result in serious opioid-induced withdr
Opioid analgesic methadone (PO, IV) Dolophine CS-II Opioid use disorder, severe chronic pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related), QTc prolongation US Boxed Warnings (all opioid analgesics): See above US Boxed Warnings (only for methadone): QTc interval prolongation and serious arrhythmia (Torsades de Pointes) have occurred during treatment; concomitant use with CYP3A4, 2B6, 2C19, or 2D6 (or stopping the same inducers) can increase methadone concentrations
Analgesic (non-opioid), antipyretic acetaminophen (PO, PR, IV) PO/PR: Tylenol, IV: Ofirmev PO, PR: OTC Pain, fever Key Side Effects: nausea, vomiting, increased hepatic transaminases US Boxed Warnings: total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity
Central analgesic; partial opioid agonist tramadol (PO) Ultram, Ultram ER CS-IV Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) US Boxed Warnings: risk of opioid addiction, abuse, and misuse which can lead to overdose and death; serious, life-threatening, or fatal respiratory depression may occur; accidental ingestion may result in fatal overdose; prolonged use in pregnancy may result in neonatal opioid withdrawal syndrome; concomitant use of opioids with benzodiazepines or CNS depressants (including alcohol), may result
Created by: Marquez35
 

 



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