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PHRM 824 - Lec 05

QuestionAnswer
Explain the differences between R/S, d/l, and D/L nomenclature systems. R/S: Absolute 3D configuration. Assign CIP rules d/l: direction molecule rotates plate-polarized light D/L: Relative configuration compared with glyceraldehyde
Explain why drug enantiomers have different biological properties. Enantiomers have different structure positioning so they may bind to the receptor differently.
Explain how the absolute stereochemistry of a molecule can influence receptor binding. Absolute structure determined 3D arrangement of the groups around a stereocenter affecting how the group aligns with the receptor binding site
List factors other than receptor binding that result in different biological properties of drug enantiomers. Non specific serum binding Metabolism Transporters
Explain the potential issues of racemic mixtures as drugs. The two enantiomers may not behave the same way in the body. One may be the main therapeutic form, while the other may be less active, inactive or produce different effects
When a pairs of stereoisomers are given, determine whether they are enantiomers, diastereomers, or geometric isomers Enantiomers are non-superimposable mirror images Diostereomers are not mirror images but they differ in 3D arrangement Geometric Isomers differ because of the restricted rotation around a double bond or ring
Created by: user-2059000
 

 



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