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WEEK 5:

Tubular function 5:

QuestionAnswer
effective ECF volume regulated by changes in Na+ excretion
osmolality (plasma Na+) is regulated by changes in H2O intake (thirst) and excretion (ADH)
what can lead to/ contribute to ECF osmolality thirst and collecting duct water reabsorption and ADH
what can lead to/ contribute to effective ECF volume RAA system Sympathetic nervous system ANP Natriuretic factors ADH (which leads to renal tubule Na+ reabsorption, increasing water retention and increase effective ECF volume)
changes in effective ECF volume are related to absolute amounts of Na+ (and thus water present)
slide 5
blood pressure in controlled by cardiovascular reflexes
explain slide 6
slide 7
almost all filtered K+ is reabsorbed before where distal sites (at which secretion occurs: principal cells of cortical and outer medullary collecting duct)
determinants of K+ secretion (2) aldosterone and plasma K+
aldosterone role/function increases Na+ reabsorption (no. & activity of Na+ channels which increases electronegativity of tubule lumen) increases Na+/K+ ATPase activity which increases cell K+ increases luminal K+ permeability (opens K+ channels)
plasma K+ increases luminal K+ permeability which increases Na+/K+ ATPase activity and stimulates secretion of aldosterone
acidosis hyperkalaemia
alkalosis hypokalaemia
explain acidosis
slide 13
Created by: 22tango
 

 



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