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CNS 3
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| Generic | Brand | Category | Indication | Side Effects | US Box Warning | Other Notes |
|---|---|---|---|---|---|---|
| lithium (PO) | Lithobid | Antimanic agent | Bipolar disorder | tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia, GI upset | ability to promptly monitor levels is necessary | narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic drug monitoring is recommended); avoid in pregnancy |
| sumatriptan (PO, intranasal, SQ) | Imitrex | Antimigraine | Migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension | |
| rizatriptan (PO) | Maxalt | Antimigraine | Migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension | |
| haloperidol (PO, IV, IM) | Haldol | First-generation antipsychotic | Schizophrenia | sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| clozapine (PO) | Clozaril | Second-generation antipsychotic | Treatment-resistant schizophrenia | sedation, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain, neutropenia | may cause severe neutropenia; may cause orthostatic hypotension, bradycardia, syncope, seizures, fatal myocarditis and cardiomyopathy; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| aripiprazole (PO, IM) | PO/IM: Abilify IM: Aristada | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | akathisia, restlessness, sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase risk of suicidal thinking and behavior in children, adolescents, and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| quetiapine (PO) | Seroquel, Seroquel XR | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase risk of suicidal thinking and behavior in children, adolescents, and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| lurasidone (PO) | Latuda | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase risk of suicidal thinking and behavior in children, adolescents, and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | CI with strong 3A4 inhibitors and inducers |
| olanzapine (PO, IM) | Zyprexa | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| risperidone (PO, IM) | PO: Risperidal IM: Risperdal Consta | Second-generation antipsychotic | Schizophrenia | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |