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Pharmacodynamics 165

QuestionAnswer
Receptor- Any macromolecule that a neurotransmitter or drug binds to initiate its effects
Drug- Chemical substance that interacts with a receptor to produce a physiologiceffect
The ability to bind to a receptor is mediated by the chemical structure of the drug that allows it to interact with _______ on the receptor Complementary Surfaces
All drugs are ______ but not all _______ are drugs Chemicals
Receptors are ______ Dynamic
_____________ May change because of disease or previous drug administration Drug Responsiveness
Both agonists and antagonists can bind to a receptor but only the ______ can activate the receptor Agonist Molecules
Agonist (drug)- Produces a Physiologic Response
Antagonist (drug)- Blocks physiologic response
Stimulation: INCREASES FUNCTION OR ACTIVITY OF A PART OF THE BODY
Irritation: PRODUCE SYMPTOMS OF INFLAMMATION AT THE SITE
Depression: LOWERS OR LESSENS ACTIVITY IN SOME BODY PART
Demulcence: SOOTHES, USED TO RELIEVE SYMPTOMS OF IRRITATION
Synergism COMBINED EFFECTS OF 2 DRUGS GREATER THAN THE EFFECTS OF EACH SEPARATELY
Antagonism: EFFECTS OF 2 DRUGS CANCEL EACH OTHER-NARCAN PREVENTS OPIATES FROM BINDING TO RECEPTOR SITES
_______ IS THE BASIS FOR SPECIFIC ANTIDOTES Antagonism
Incompatibility: PHYSICAL INTERACTION OF 2 DRUGS INTERFERES WITH THE EFFECT OF AT LEAST 1 OF THE DRUGS
Tolerence: LESSENING OF DRUG’S EFFECTS DUE TO CONTINUAL PRESENCE OF DRUG-LARGER DOSES ARE NEEDED TO ACHIEVE SAME EFFECTS
Interference: ONE DRUG ACCELERATES OR SLOWS METABOLISM OR EXCRETION OF ANOTHER DRUG
Side Effect: Unintended action of a drug – good or bad
Toxicity: Higher concentrations can lead to higher toxic effec
Allergic Reaction: Immune mediated response; immediate or delayed effects
GI EFFECTS: MOST MEDS CAN CAUSE N/V AND DIARRHEA. GIVING MED WITH FOOD, IF NOT CONTRAINDICATED WILL OFTEN LESSEN THE UNPLEASANT EFFECTS
HEMATOLOGICAL EFFECTS: SOME MEDS ESPECIALLY THOSE TO TREAT CANCER CAUSE BONE MARROW DEPRESSION CAUSING CLIENT TO BE SUSCEPTIBLE TO INFECTION
ANAPHYLAXIS: EXTREME LIFE THREATENING HYPERSENSITIVITY TO DRUG
HEPATOTOXICITY: ABILITY OF MANY DRUGS TO DAMAGE LIVER, ESPECIALLY IF COMBINED WITH ALCOHOL INTAKE
NEPHROTOXICITY: ABILITY OF SOME DRUGS TO DAMAGE RENAL STRUCTURES DURING EXCRETION
CARCINOGENICITY: ABILITY OF DRUG TO CAUSE CANCER BY ALTERING BODY CELLS
TERATOGENICITY: ABILITY OF DRUG TO CAUSE DAMAGE TO FETUS
ERRORS IN MEDICATION ADMINISTRATION ARE ONE OF THE MOST COMMON REASONS FOR LAWSUITS. CHARGE IS USUALLY ________ PROFESSIONAL NEGLIGENCE (MALPRACTICE)
Created by: user-2016295
 

 



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