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Pharmacokinetics 165

Part 1

QuestionAnswer
What is the area of pharmacology that focuses on the method for achieving effective drug administration? Biopharmaceutics
A drug _______ is a substance into which a drug is compounded for initial delivery into the body Vehicle
A _________ is the combination of both the drug and the vehicle used to deliver the drug Dosage Form
________ help the powdered mass to maintain form when compressed in the manufacturing process Fillers
Tablet- generally consists of an active ingredient (drug), various fillers and disintegrators, dyes, flavoring agents, and an outside coating
What is required for the solid to become a solution before absorption across a biologic membrane The Disintegration Process
The _________ may help with palatability and aid in the drug-releasing process Coating
_________ TABLETS ARE COMPACTED WITH NO SPECIAL COATING; THEY ARE SUBJECT TO CHEMICAL DEGRADATION FROM THE ENVIRONMENT Compression
_______ TABLETS HAVE A THIN LAYER OF SUGAR COATING DESIGNED TO MASK BAD TASTE AND TO PROTECT THE ACTIVE INGREDIENTS FROM CHEMICAL OXIDATION. Sugar-Coated
________ TABLETS HAVE A THIN COATING OF MATERIAL OTHER THAN SUGAR. THIS TYPE OF COATING SERVES THE SAME FUNCTION AS A SUGAR COATING BUT IS LESS EXPENSIVE TO MANUFACTURE Film-Coated
________TABLETS ARE DESIGNED TO PASS THROUGH THE GASTRIC AREA AND RELEASE THE ACTIVE INGREDIENTS INTO THE SMALL INTESTINE. THIS TECHNOLOGY IS USED TO PREVENT THE STRONGLY ACIDIC CONTENTS OF THE STOMACH FROM CHEMICALLY DESTROYING THE ACTIVITY OF A DRUG Enteric-Coated
Capsule- Generally consist of either a hard or a soft gelatin shell that encloses the active ingredient. Designed to mask taste, allow for ease of swallowing, and contribute to a controlled-release mechanism
________ are generally in the form of lozenges or pastilles Troches
Troches- Solids that contain medicine in a hard sugar or glycerinated gelatin base designed to dissolve slowly in the mouth
_________ are solid dosage forms generally designed for vaginal or rectal delivery Compressed Suppositories (Inserts)
Solution- A homogenous mixture of solid, liquid, or gas dissolved in another liquid. The solute (drug) is dispersed in the solvent (vehicle)
Emulsion- A dosage form consisting of two immiscible liquids. One liquid appears as globules uniformly dispersed throughout the other liquid
Suspension- A solid medication dispersed throughout a liquid medium. A suspending agent is generally added to help maintain uniform dispersion.
__________ Generally require agitation (shaking) before administration Suspensions
Thrombosis- local coagulation or clotting of the blood in a part of the circulatory system; if broken away can become an embolus
Phlebitis- Inflammation of the walls of the vein
Air emboli- Occurs when air is introduced into the vein
The human body is not harmed by _______, but a good practice is to purge all air bubbles from the formulation and administration sets before use Small amounts of Air
__________ is generally small pieces of glass that chip from the formulation vial or rubber that comes from the rubber closure on injection vials Particulate Material
_________ are typically used for oxygen therapy, anesthesia, and aerosol inhalers Gas Dosage Forms
Most anesthetics are _______ at room temperature Gaseous
A medication in solid form will generally require ______ than the same medication in liquid form More Time to enter the Body
Pharmacokinetics- The process of how a drug is absorbed, distributed, metabolized, and eliminated throughout the body
For absorption to occur, the _______ of the drug and the vehicle must be compatible with the site for administration Physiochemical Properties
A large surface area allows for_______ than a smaller surface area does Better Absorption
_________ give rise to some of the largest surface areas for absorption in the human body Pulmonary Alveoli and GI Rugae
Distribution- The transport of a drug in body fluids from the bloodstream to various tissues of the body and ultimately to its site of action
Conjugation- Transforms a drug from a lipid-soluble substance that can cross biologic membranes to a water-soluble substance that can be excreted through the biliary tract
_______Are Given By injection under or through one or more layers of skin or mucous membrane Parenteral Dosage Forms
Created by: user-2016295
 

 



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