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Musculoskeletal

BrandGenericCategoryIndicationsEssential Knowledge
Zanaflex tizanidine (PO) Alpha2 agonist Spasticity Key Side Effects: drowsiness, hypotension, dizziness, xerostomia, weakness
Plaquenil hydroxychloroquine (PO) Aminoquinolone RA, SLE, malaria Key Side Effects: retinal toxicity, rash, diarrhea Other Notes: long-term use has been associated with cardiomyopathy, bone marrow suppression, QT prolongation, and neuromuscular effects (i.e., myopathy, palsies, and progressive weakness)
Voltaren Gel (OTC) diclofenac (topical) NSAID OA Key Side Effects: pruritus, rash
Voltaren diclofenac (PO) NSAID OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea US Boxed Warnings: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Motrin, Advil (all OTC) ibuprofen (PO) NSAID OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea US Boxed Warnings: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Mobic meloxicam (PO) NSAID OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea US Boxed Warnings: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Indocin indomethacin (PO) NSAID OA, RA, acute pain, gout Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea US Boxed Warnings: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Naprosyn, Anaprox, Aleve (all OTC) naproxen (PO) NSAID OA, RA, acute pain, gout Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea US Boxed Warnings: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Toradol keterolac (PO, IV) NSAID Pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea BW: may increase the risk of serious/potentially fatal cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious GI adverse events including ulceration, bleeding, perforation US Boxed Warning (only for ketorolac): indicated for short term use (≤ 5 days) Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Celebrex celecoxib (PO) NSAID, COX-2 selective OA, RA, acute pain Key Side Effects: diarrhea, dyspepsia, abdominal pain, flatulence, nausea US Boxed Warnings: may increase the risk of serious (and potentially fatal) cardiovascular thrombotic events, MI, and stroke; may increase the risk for serious (and potentially fatal) gastrointestinal adverse events including ulceration, bleeding, and perforation Other Notes: may reduce renal blood flow and compromise existing renal function (avoid in patients with renal disease, heart failure, and cirrhosis)
Flexeril, Amrix, Fexmid cyclobenzaprine (PO) Skeletal muscle relaxant Muscle spasm Key Side Effects: drowsiness, dizziness, xerostomia, fatigue Other Notes: use may cause prolonged cardiac arrhythmias, and tachycardia; CI within 14 days of MAOI therapy
--- baclofen (PO) Skeletal muscle relaxant Spasticity Key Side Effects: drowsiness
Robaxin methocarbamol (PO) Skeletal muscle relaxant Muscle spasm Key Side Effects: drowsiness
Transdermal: Lidoderm (OTC) IV: Xylocaine lidocaine (transdermal, IV) Transdermal: topical analgesic IV: antiarrhythmic Transdermal: pain IV: ventricular arrhythmias Key Side Effects (transdermal): dermatitis, erythema, urticaria, skin depigmentation, skin edema Key Side Effects (IV): bradycardia Other Notes: patch may remain in place for up to 12 hours in any 24-hour period, patch may be cut
Colcrys colchicine (PO) Antigout agent Gout Key Side Effects: diarrhea, nausea, vomiting, bone marrow suppression, myopathy (including rhabdomyolysis)
Zyloprim allopurinol (PO) Xanthine oxidase inhibitor Gout Key Side Effects: diarrhea, nausea, rash, leukopenia, thrombocytopenia Other Notes: rare association with severe (and potentially fatal) allopurinol hypersensitivity syndrome (risk highest in certain Asian populations)
Anectine succinylcholine (IV) Depolarizing neuromuscular blocking agent Neuromuscular blockade for intubation for procedures Key Side Effects: hyperkalemia, myalgia, malignant hyperthermia (rare) US Boxed Warning: acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatric patients with undiagnosed skeletal muscle disease
Enbrel etanercept (SQ) Anti-tumor necrosis factor alpha inhibitor RA Key Side Effects: infection, injection site reaction, headache, nausea US Boxed Warning: serious infections, malignancies such as lymphoma
Humira adalimumab (SQ) Anti-tumor necrosis factor alpha inhibitor RA, Crohn's Disease, Ulcerative Colitis Key Side Effects: infection, injection site reaction, headache, nausea US Boxed Warning: serious infections, malignancies such as lymphoma
Created by: Kaitlynyip
 

 



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