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Cardio 1 Drugs

GenericBrandIndicationDrug ClassDoseBoxed WarningMOA
atenolol Tenormin Hypertension Beta-blocker, Beta-1 Selective 50 - 100 mg PO per day Cessation of Therapy (abrupt discontinuation can worsen cardiac conditions) inhibits beta1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)
benazepril Lotensin Hypertension Angiotensin-Converting Enzyme (ACE) inhibitor 10 - 40 mg PO per day Fetal toxicity inhibits conversion of angiotensin I to angiotensin II
carvedilol Coreg, Coreg CR Hypertension, Heart failure with reduced ejection fraction Beta-blocker with alpha blocking activity IR: 3.125 - 25 mg PO BID ER: 20 - 80 mg PO once daily None inhibits B1 adrenoceptors in heart (preventing norepi from increasing HR and BP) and kidney (preventing norepi from increasing renin release); inhibits B2 adrenoceptors; inhibits a1 adrenoceptors in blood vessels, decreasing peripheral vascular resistance
clonidine Catapres Hypertension Alpha 2 agonist 0.2 - 0.8 mg PO per day Patch: 0.1 - 0.3 mg per 24-hour patch applied once every 7 days Epidural use centrally acting alpha 2 adrenergic receptor
enalapril Vasotec Hypertension Angiotensin-Converting Enzyme (ACE) inhibitor 5 - 40 mg PO per day Fetal toxicity inhibits conversion of angiotensin I to angiotensin II
hydralazine Apresoline Hypertension Vasodilator 10 - 50 mg PO QID None direct acting arteriole vasodilator that relaxes smooth muscle cells in resistance arterioles
labetalol Normodyne, Trandate Hypertension Beta-blocker with alpha-blocking activity PO: 100 - 600 mg PO BID None inhibits B1 adrenoceptors in heart (prevent norepi from increasing HR and BP) and kidney (prevent norepi from increasing renin release). inhibits B2 adrenoceptors. Inhibits a1 adrenoceptors in blood vessels, decreasing peripheral vascular resistance
lisinopril Zestril Hypertension Angiotensin-Converting Enzyme (ACE) inhibitor 5 - 40 mg PO once daily Fetal toxicity inhibits conversion of angiotensin I to angiotensin II
losartan Cozaar Hypertension Angiotensin II Receptor Blocker (ARB) 25 - 50 mg PO once daily Fetal toxicity selective antagonist of the angiotensin II type 1 receptor (AT1R)
metoprolol succinate Toprol-XL Hypertension, Heart failure with reduced ejection fraction Beta-blocker, Beta-1 Selective 12.5 - 200 mg PO once daily None inhibits beta1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)
metoprolol tartrate Lopressor Hypertension Beta-blocker, Beta-1 Selective 25 - 200 mg PO BID None inhibits beta1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)
nebivolol Bystolic Hypertension Beta-blocker, Beta-1 Selective 5 - 40 mg PO once daily None inhibits beta1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)
propanolol Inderal LA, Inderal XL Hypertension Beta blocker, non-selective 80 - 160 mg PO per day in 1-4 divided doses (based on IR or ER formulation) None inhibits beta1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release); allso inhibits beta 2 adrenoceptors
ramipril Altace Hypertension Angiotensin-Converting Enzyme (ACE) inhibitor 2.5 - 20 mg PO per day in 1-2 divided doses Fetal toxicity inhibits conversion of angiotensin I to angiotensin II
valsartan Diovan Hypertension Angiotensin II Receptor Blocker (ARB) 80 - 320 mg PO once daily Fetal toxicity selective antagonist of the angiotensin II type 1 receptor (AT1R)
Created by: mcasada
 

 



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