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clinical PK quiz 1
| term | definition |
|---|---|
| pharmacokinetics | what the body does to the drug |
| pharmacodynamics | what the drug does to the body |
| absorption | passage of drug through physiological barriers before reaching vascular system |
| volume of distribution | hypothetical volume that relates drug serum concentration to amount of drug in the body |
| metabolism | Chemical conversion of drug molecule |
| excretion | irreversible removal of drug from body |
| clearance | volume of serum or blood cleared of the body per unit of time |
| steady state concentration | rate of drug administered equals the rate of drug removal |
| Linear pharmacokinetics | steady state concentration changes proportionally with dose changes |
| nonlinear pharmacokinetics | steady state concentration increases more than proportionally to dose changes |
| half life (T1/2) | time it takes for serum drug concentration to decrease by one half |
| elimination rate constant(Ke) | rate a drug is eliminated from the body per unit of time |
| Cmax or Peak | Highest concentration after a drug is administered |
| Cmin or trough | lowest concentration that can be measured right before the next dose of medication that is administered |
| random level | drug concentration taken at any point of time either before or after a dose of medication is administered |
| AUC | total drug exposer over a 24 hour period of time |
| distribution | passage of drug from bloodstream to tissue/organ |
| clinical pharmacokinetics | application of pharmacokinetic principles design individualized drug regimens that are safe and effective |