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hematology 2 exam 1
| Question | Answer |
|---|---|
| LE prep | blood is taken, agitated and left to stand. damaged cells with release their nuclei, which get coated with antinuclear antibodies (if present, as in the case of lupus). clumped nuclei get stained blue, then phagocytized, producing LE cells |
| LE prep has been replaced by | more sensitive ANA titers |
| malignant lymphomas are divided into | hodgkin's lymphoma (disease) and non-hodgkin's lymphoma (lymphocytic lymphomas) |
| the morphological hallmark of Hodgkin's lymphoma is the | reed sternberg cell |
| commonly used classification scheme for hodgkins lymphoma | rye |
| reed sternberg cells have been found in | melanoma, viral infection, myeloproliferative disorders, stromal malignancies |
| what cell types are common in mixed cellularity hodgkins disease | lymphocuytes, histiocytes, plasma cells, reed sternberg cells |
| what virus is associated with the pathogenesis of Hodgkin's disease? | EBV |
| In ___________, reed sternberg cells and variants predominate, and lymphocytes are sparse. | lymphocyte depletion hodgkin's lymphoma |
| asymptomatic mediastinal mass is common with what form of hodgkin lymphoma | lymphocyte rich classic hodgkin lymphoma |
| reed sternberg variant cells seen in nodular sclerosing hodgkins lymphoma is called | lacunar cells |
| with therapy, the 10 yr survival of stage I and II of hodgkin's lymphoma is | over 80% |
| hodgkin lymphoma often presents with | painless lymph node swelling |
| diagnosis of hodgkin lymphoma requires ___________ and ______________ | tissue biopsy and microscopic evaluation |
| therapy for hodgkin lymphoma is based off the | stage of the disease |
| all folicular center lymphomas are composed of a mixture of | centrocytes and centroblasts |
| burkitts lymphoma is characterized by | uniform nuclei, high mitotic rate, "starry sky" pattern |
| lymphoblastic lymphomas are associated with | high frequency of developing acute lymphoblastic leukemia, mediastinal mass, potentially curable in young patients, usually TdT positive |
| mycosis fungiodes, searzys syndrome, hepatospenic gamma/delta lymphoma, angioimmunoblastic lymphadenopathy with dysproteinemia like T cell lymphoma are all disorders of what cell | T cells |
| diffuse aggressive lymphomas are | rapidly fatal if untreated |
| burkitts lymphoma often causes tumors where in children | on the face |
| ann arbor is used for all non-hodgkins lymphoma except | burkitts |
| the plasma cell is the fully differentiated | B lymph |
| plasma cell disorders are also called | monoclonal gamopathies |
| plasma cell disorders are characterized by | excess production of immune globulins |
| immune globulins are produced by | B lymphs |
| Wrights stains of peripheral blood smears from some patients with myeloma coloration is due to increased background staining of the high level of _________ portion of the blood | immunoglobulin |
| when rouleaux is present, the ESR will be | increased |
| what immunoglobulin has the highest molecular weight | IgM |
| serum protein electrophoresis demonstrates the absebnce of a gamma peak, which is consistent with which plasma cell disorder | hypogammaglobulinemia |
| what does immunoelectrophoresis determine | specific antibodies present |
| ___________ is the immunologic technique capable of quantitating a monoclonal immunoglobulin | radial immunodiffusion |
| urine immunoelectrophoresis is used to distinguish between _____________ chains in urine | kappa/lambda |
| what is a plasmacytoma? | tumors composed of plasma cells |
| what are the signs and symptoms of plasma cell disorders | fatigue, hypercalcemia, bone pain, serum hyperviscosity |
| multiple myeloma affects which age group | elderly |
| russel bodies | seen in multiple myeloma as a clump of aggregated immunoglobulin, which stains red with wright-giemsa stain |
| which light chain protein is characteristically present in multiple myeloma | bence-jones |
| multiple myeloma | incurable blood cancer that begins in the bone marrow, crowds out healthy RBC's and produces an abnormal antibody (M-protein), damaging the kidneys and bones |
| ________ light chains are most commonly found in patients with myeloma related amyloidosis. | lambda |
| multiple myeloma manifestation; the formation of abnormal proteins in organ systems due to deposition of immunoglobulin light chains leading to kidney and renal dysfunction | amyloidosis |
| bacterial infection is the most common cause of death in multiple myeloma patients due to | decreased production of normal immunoglobulin |
| what is the cause of decreased production of formed elements in the marrow (red cells, white cells, PLT's) seen in patients with multiple myeloma? | malignant plasma cell mass replaces normal marrow |
| myeloma cells may difusely infiltrate organs such as the ________, causing enlargement and dysfunction | liver, spleen, kidney |
| B2 microglobulin used in conjunction with serum |
Created by:
kingsleya27