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clinchem endocrine
| Question | Answer |
|---|---|
| endocrine system | regulates and maintains various body functions by synthesizing and releasing hormones |
| endocrine glands secrete into the | ECM and blood (ductless system) |
| The target of effector hormones is other _____________ | tissues |
| neurohypophysis | posterior pituitary |
| posterior pituitary hormones | oxytocin and antidiuretic hormone |
| Releasing factors are produced by the ________________________ and secreted into the anterior pituitary | hypothalamus |
| adenohypophysis | anterior pituitary |
| prolactin | stimulates milk production |
| The pituitary glands have been described as looking similar to: | garbanzo beans |
| Hypersecretion of ___________________ during childhood may result in giantism | growth hormone |
| the hypothalamus connects the CNS to the ___________ system | endocrine |
| The target of tropic hormones are other _______________ | glands |
| calcium reference range | 8.6-10 mg/dL |
| what is the most important test for hypothyroidism? | TSH |
| hypothyroid patients may also have | anemia |
| 3 chemical types of proteins | 1. polypeptides 2. amino acid derivatives 3. steroids |
| anterior pituitary hormones | FSH, LH, GH, ACTH, prolactin, TSH |
| pineal gland hormones | melatonin and serotonin |
| adrenal medulla hormones | epinephrine, norepinephrine, dopamine |
| what is the major glucocorticoid in humans? | cortisol |
| what is the most important mineral corticoid | aldosterone |
| cortisol is highest in the _____________ and lowest in the __________ | morning; afternoon |
| growth hormone is highest in the | evening |
| elevated GH causes .... decreased GH causes..... | gigantism, acromegaly dwarfism, simmons |
| calcitonin is made in the | thyroid gland |
| vanillylmandelic acid (VMA) comes from | the metabolization of epinephrine and norepinephrine |
| dexamethasone suppression test documents the | hypersecretion of adrenocortical hormones (cortisol) |
| thyroxine binding globulin | protein carrier for thyroid hormones |
| transcortin | protein carrier for cortisol |
| what is the primary active thyroid hormone in the blood | T3 |
| anterior pituitary hormone release is controlled by | TRH, CRH, GnRH, GHRH |
| what is the most potent estrogen? | estradiol |
| organs that secrete steroid hormones | adrenal glands, gonads, placenta |
| what hormone is measured when pregnant | HCG |
| mothers of babies with down syndrome have decreased | estriol |
| what hormone is related to zollinger-ellison syndrome> | gastrin |
| hyperparathyroidism increases______ and decreases ____ | Ca++ ; P |
| symptoms of hyperthyroidism | heat intolerance, flushed skin, palpitations, tachycardia, weight loss, restlessness, proptosis |
| 2 important metabolites of catecholamines | 1. Vanillylmandelic acid (VMA) 2. homovanillic acid (HMA) |
| cyclic AMP is activated by | epinephrine, glucagon, TSH, LH and FSH, ADH and PTH |
| hydatidiform mole | noncancerous tumor that develops from an abnormal fertilized egg |
| what surges before ovulation | LH |
| what maintains pregnancy | progesterone |
| in radioimmunoassay (RIA), the final gamma point is _________ proportional to the amount of target substance in the patient sample | inversely |
| tropic hormone | target is another endocrine gland |
| hormones function to | maintain homeostasis, regulate growth and development, promote sexual maturity and reproduction, regulate energy produced and stabilize the metabolic rate, adjust stress, regulate the release of other hormones |
| what hormones are lipid soluble | steroid and ionated hormones |
| what is the largest endocrine gland | thyroid |
| graves disease | autoimmune disease; body produces Ab to the thyroid causing a hyperthyroid reaction |
| addisons disease | decreased ACTH and/or cortisol; failure to thrive, dehydration, weight loss, weakness, fatigue |
| cushings syndrome | hypercortisol disease; increased ACTH; truncal obesity, buffalo hump, protein wasting, poor wound healing, hyperglycemia |
| cortisol | has an anti-insulin effect, effects water and electrolyte balance, suppresses inflammatory and allergic reactions |
| cortisol is regulated by | ACTH and CRH |
| pheochromatocytomas | tumors of the adrenal medulla; causes and increase in catecholamines released |
| FSH | works only with LH; causes estrogen production |
| hyperparathyroidism vs hyperparathyroidism | hyper: elevated calcium --> kidney stones hypo: decreased calcium and PTH, increased P ; tetany and neuromuscular problems |
| hypothyroid hormone levels | decreased T3 and T4, increased TSH |
| hashimotos | autoimmune disease where body eventually stops producing T3 and T4 ; cold interolance, dry skin, weight gain, eyebrow loss |
| effector hormones | effect non endocrine tissues |
| 5 structural classes of hormones | protein, glycoprotein, peptides, AA derivatives, steroids |