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RxP Anxiolytics
| Front | Back |
|---|---|
| Program name: Chill Switch | Mellow greetings, says associate Bob who GABA’s on about SaNangeles as a Haven while Scraps live Anxious Below. |
| Anticonvulsants | PRE/GABA ↓excitation by blocking Ca2+ channel = ↓ contraction ↑ relaxation Pregabalin - faster with ↑bioavailability (Na-, Glu-, GB+) Gabapentin - benzo like with abuse potential (Na-, GB+) |
| Benzos | GB+ = SNS ↓ “AZE” in the name ↑ frequency of GABA Cl- channel opening = negative hyperpolarization |
| TOM spartan moved fast to Lure to A Tough Criminal to the Cryoprison in Diaz | Half life differences of benzos Opens Cl- channel more frequently = GABAa+ |
| TOM spartan | Short acting .5 life (1-12 hrs) Triazolam - rapid peak blood levels Oxazepan - “Outside the liver” metabolism Midazolam for panic attacks, surgery |
| Lure A Tough Criminal | Med acting benzo .5 life (12-40hrs) Lorazepam - outside the liver, slow clearance, peak blood level Alprazolam Tamazepam - outside the liver, sleep use Clonazepam for anxiety and panic DO |
| Cryoprison in Diaz | Long acting benzo .5 life (40-250hr = days) Chlordiazepoxide Diazepam (40-520hrs) rapid onset, good for ETOH withdrawal and chronic panic DO |
| EZZZ Sleep mode in the Cryoprison | Hypnotics of anxiolytics Open Cl- channel more frequently = GABAa+ |
| Zopliclone | EZzz sleep mode in the cryoprison Hypnotic 8hr .5 life es)zopiclone has better side effects |
| Zaleplon | eZzz sleep mode in the cryoprison Hypnotic 4hr .5 life |
| Zolpidem | ezzZ sleep mode in the cryoprison Hypnotic 6hr .5 life |
| Suvorexant | ezzz Sleep mode in the cryoprison Hypnotic Calms orexin receptor to reduce alertness |
| Melatonin | ezzz sleep Mode in the cryoprison Hypnotic OTC neurotransmitter >5mg is unnecessary |
| Hunting Dinner in the Dark | scraps live anxious below Sedatives ie Antihistamines Hydroxyzine Doxylamine Diphenhydramine |
| Hydroxyzine | Hunting dinner after dark HIS- H1 antagonist prn to fall asleep, but no sleep quality |
| Doxylamine | hunting Dinner after dark HIS-, ACh- Best option for sleep Inexpensive |
| Diphenhydramine | hunting dinner after Dark HIS-, ACh- For kids, babies Dementia risk ↓EPS symptoms (see ADAPT) |
| But Police are Petrified | SaNangeles SE/NE anxiolytics Buspirone Propranolol Prazosin |
| Buspirone | But police are petrified SE↔︎, DA- Anxious depression type NO sedation, slow onset Withdrawal symptoms Grapefruit restriction |
| Propranolol | but Police are petrified Beta1/2 blockers = NE- For physical symptoms of anxiety i.e. performance Not for asthmatics |
| Prazosin | but police are Petrified Alpha1 block = NE- Good sleep/relief from PTSD nightmares HoTN risk |
| Barbiturates | scraps live anxious Below ↑ DURration of Cl- channel opening = GABA+ “itals” Celebrity deaths and executions |
| GGs Three pole strip club | GABA - presynaptic inhibitor Glutamate - postsynaptic activator (NMDA, AMPA) (Na+) - an ↑= action potential for depolarization (Ca2+) - an ↑= 2ndM = ↑ cell activity from depolarization (Cl-) an ↑= hyperpolarization for reduced cell activity |
| Orexin 1/2 | Sleep regulating neurotransmitter Hypothalamus location Metabotropic Actuates arousal systems of ACh, monamines Co-release w/glutamate = excitatory |
Created by:
dttrain