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NAPLEX
Opportunistic infections
| Question | Answer |
|---|---|
| what is the primary prophylaxis regimen for PJP | bactrim DS or SS daily |
| what is the criteria for initiating primary prophylaxis regimen for PJP? | CD4 count <100 or CD4 count of less than 100-200 if HIV RNA level is detectable |
| what are the alternative drug treatment for PJP in the setting of sulfa allergy? | dapsone, atovaquone, and pentamidine |
| what are the alternative drug treatment drugs for PJP in the setting of G6PD deficiency? | atovaquone and pentamidine |
| what does pyrimethamine cause that leucovorin is added for the rescue thearapy | myelosuppresion |
| what is the criteria for starting primary prophylaxis for toxoplasma gondii encephalitis | toxoplasma IgG (+) AND CD4 count <100 |
| what is the alternative drug treatment for toxoplasma gondii encephalitis | Dapsone + pyrimethamine + leucovorin or atovaquone |
| Is MAC primary prophylaxis required on a patient who starting ART therapy immediately? | no |
| when do you initiate MAC primary prophylaxis? | if not taking ART, CD4 count <50, and no active MAC infection |
| what do you discontinue the primary prophylaxis treatment? | when a patient is taking fully suppressive ART |
| DOC for thrush? | fluconazole |
| is there secondary prophylaxis for thrush? | no |
| what is the preferred treatment for cryptococcal meningitis? | amphotericin B + flucytosine |
| what is the alternative treatment for crytpcoccal meningitis? | fluconazole + flucytosine |
| what is the preferred treatment for MAC | clarithromycin/ azithromycin + ethambutol |
| what is the preferred treatment for toxosplasma gondii encephalitis? | pyrimethamine + leucovorin + sulfadiazine |
| what is the alternative drug treatment for toxoplasma gondii encephalitis? | clindamycin + pyrimethamine + leucovorin |
| what are the risks for a patient getting toxoplasma gondii encephalitis? | ingestion of undercooked/raw meat or shell fish or contact with cat feces/litter |