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NAPLEX
ID 3
| Question | Answer |
|---|---|
| what are the 2 lipid formulations of amphotericin B | Abelcet and AmBisome |
| what is the boxed warning that amphotericin B has? | do not mix up the formulations. Med errors have resulted in cardiopulmonary arrest and death |
| Is there a dose that the conventional amphotericin B should NOT exceed? | 1.5 mg/kg/day |
| What electrolyte imbalances does amphotericin B cause? | decreases K and Mg |
| what do you if you get an infusion reactions from amphotericin B deoxycholate? | premedicate with tylenol, NSAID, benadryl and/or hydrocortisone |
| Since amphotericin B causes hypokalemia, what drug does it have effects on? | it can increase the risk of digoxin toxicity |
| what does flucytosine get converted to? | fluorouracil |
| should flucytosine be used alone? | no, recommended to be used in combination with amphotericin B for the treatment of invasive cryptococcoal (meningitis) or candida |
| what is the side effect of using flucytosine? | dose-related myelosuppresion |