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Amiodarone

Cardiac Pharmacology

QuestionAnswer
What is the classification of Amiodarone? Class III antiarrhythmic Potassium channel blockers.
What is the pharmacodynamic of Amiodarone? Slows potassium efflux which delays repolarization.
What are the indications of Amiodarone? - VF, Pulseless VT, unresponsive to shock delivery, CPR, and Epi. - Recurrent, hemodynamically stable VT with a pulse. - Life-Threatening Arrhythmia
What are the precautions of Amiodarone? - Severe life-threatening hypotension - Terminal elimination is extremely long (half-life lasts up to 40 days)*Toxic, appropriate monitoring needed. May be used for treatmenting some atrial and ventricular rhythms & life-threatening arrhythmias*
What are the contraindications of Amiodarone? - Allergic to medication - Bradycardias to include AV blocks - Breastfeeding mothers
What are the side effects of Amiodarone? - Severe hypotension - Bradycardia - Prolong QT which can lead to TdP
What is the dose for Amiodarone when your patient is showing VF/Pulseless VT in Cardiac Arrest and unresponsive to CPR, Shock and Epi? 1st 300 mg IV/IO push 2nd 150 mg IV/IO push if needed.
When your patient in having a life threatening arrhythmia what is the dosage of Amiodarone to give? - 1st Dose: Rapid Infusion of 150mg over 10 minutes (15 mg/min) - 2nd Dose: May repeat at same dose every 10 minutes if needed. - 3rd Slow Infusion: 360 mg IV over 6 hours (1 mg/min) - 4th Maintenance Infusion: 540 mg over 18 hours (0.5 mg/min)
Created by: ejarami4
 

 



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