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DM-Methoxyflurane
| Question | Answer |
|---|---|
| Class | Inhaled volatile anaesthetic |
| Action | Methoxyflurane is a volatile anaesthetic agent, the exact mechanism of action is unknown. |
| Indications | Relief of moderate to severe acute pain in conscious hemodynamically stable adult patients |
| Contraindications | Malignant Hyperthermia, antibiotics, DLOC, History of liver dysfunction, Age, Renal, Understanding, muscular dystrophy, pregnancy |
| Cautions | None |
| Side effects | Dizziness Drowsiness Headache Cough Nausea or vomiting Decrease inhibition |
| Dosage | Inhaled: 3 mL self-administered; may repeat once to a max of 6mL No more than 6 mL of methoxyflurane to be administered to a patient in a 48-hour period. |
| Route | Inhaled (self-administered) |
| Onset, Peak, Duration | Onset: 1 – 3 minutes or approximately 8 – 10 regular breaths Duration: 3 – 5 minutes once self-administration discontinued; a 3 mL dose lasts approximately 25 minutes |
| Elimination | The methoxyflurane that is not exhaled unaltered is metabolized by the liver, and excreted in urine |
| Iatrogenic Overdose | Methoxyflurane causes significant nephrotoxicity at higher doses Overdose may cause respiratory depression |